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Pedro F. N. Souza et al.
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Wenhao O. Ouyang et al.
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Young-Jun Park et al.
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Allison J. Greaney et al.
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Kamyab Javanmardi et al.
Summary: The Spike Display platform characterized 200 variant SARS-CoV-2 spikes, revealing a public epitope in the N-terminal domain loops that is recognized by most NTD-binding nAbs. Mutations in NTDs of variants like B.1.1.7, B.1.351, B.1.1.28, B.1.427/B.1.429, and B.1.617.2 impact spike expression and escape most NTD-targeting nAbs. Certain variants like B.1.351 and B.1.1.28 completely evade binding by a potent ACE2 mimic.
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Yinghui Liu et al.
Summary: Epidemiological studies have shown that bats are the natural reservoir of SARS-CoV-2, but the host range and intermediate hosts for transmission are unknown. This study characterized the ability of ACE2 from various species to support viral entry, suggesting a potentially broad host tropism of SARS-CoV-2. Analysis of ACE2 orthologs revealed that New World monkey ACE2 could not support viral entry, with genetic determinants restricting this interaction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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Edward C. Holmes et al.
Summary: This article critically reviews the current scientific evidence to help clarify the origin of SARS-CoV-2. Recent debate has centered around two competing ideas: a laboratory escape scenario and zoonotic emergence.
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Bas B. Oude Munnink et al.
Summary: This review summarizes the current knowledge on key viral mutations and variants, emphasizing the need for a systematic approach to link global genomic surveillance with timely assessment of the phenotypic characteristics of novel variants in preparation for the next phase of the pandemic.
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Kathryn M. Hastie et al.
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