Potential cross-species transmission of highly pathogenic avian influenza H5 subtype (HPAI H5) viruses to humans calls for the development of H5-specific and universal influenza vaccines

Summary: Avian influenza viruses, especially H5 and H7 subtypes, have caused significant human and animal health issues globally. These viruses have resulted in numerous infections and deaths, impacting wild birds and domestic poultry industry. China's cull plus vaccination strategy has been successful in controlling the outbreaks and minimizing the losses, making it a valuable approach for global poultry health.

EMERGING MICROBES & INFECTIONS (2023)

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Article Biochemistry & Molecular Biology

Design, Synthesis, Biological Evaluation, and Molecular Dynamics Simulation of Influenza Polymerase PB2 Inhibitors

Xinhong Li et al.

Summary: Two pimodivir analogs containing 2,3-dihydro-imidazopyridine fragment were synthesized and evaluated for their anti-influenza virus activity. These compounds showed good stability and high inhibitory effect on the influenza polymerase PB2.

MOLECULES (2023)

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Article Multidisciplinary Sciences

Modifications in the piperazine ring of nucleozin affect anti-influenza activity

Erick Correa-Padilla et al.

Summary: This study analyzed piperazine-modified nucleozin analogs to increase conformational freedom, contributing to the research of nucleozin analogs' discovery and design. A new synthetic strategy to obtain nucleozin and its analogues was also described, and two of them were evaluated in vitro. Although the analogues were less active, the loss of activity highlighted the significance of the piperazine ring for maintaining the activity of nucleozin analogs. This result agrees with the prediction of anti-influenza activity made with a QSAR model presented in this work. The proposed model and synthetic route will be useful for the further development of nucleozin analogs with antiviral activity.

PLOS ONE (2023)

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Article Cell Biology

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

Zezhong Liu et al.

Summary: A new STING agonist CF501 has been discovered to enhance the effectiveness of vaccines. CF501-adjuvanted vaccines elicited strong immune responses in mice, rabbits, and rhesus macaques, producing potent neutralizing antibodies against various SARS-CoV-2 variants and mutants. The immunized animals showed long-lasting immune responses and reduced viral load after SARS-CoV-2 challenge.

CELL RESEARCH (2022)

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Article Environmental Sciences

Environmental factors and spatiotemporal distribution characteristics of the global outbreaks of the highly pathogenic avian influenza H5N1

Wei Chen et al.

Summary: The study analyzed the global outbreaks of highly pathogenic avian influenza H5N1 from 2005 to 2019, identifying peak occurrences in winter and spring with clustering patterns. Environmental factors like water distance and road distance were found to be protective, while temperature was identified as a risk factor. These findings can serve as a reference for understanding the spread of COVID-19 amid the global pandemic.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Article Biology

Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China

Pengfei Cui et al.

Summary: The study analyzed samples of wild birds and poultry in China, identifying two distinct genotypes of the H5N8 virus circulating in different bird species. The research also revealed the origin and spatiotemporal spread of these genotypes in 2020 and 2021. Additionally, the study showed that vaccinated poultry in China were fully protected against H5N8 virus challenge, highlighting the importance of vaccination to prevent the spread of H5N8 avian influenza.

SCIENCE CHINA-LIFE SCIENCES (2022)

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Article Virology

Detection of Highly Pathogenic Avian Influenza Virus H5N1 Clade 2.3.4.4b in Great Skuas: A Species of Conservation Concern in Great Britain

Ashley C. Banyard et al.

Summary: The UK and Europe have experienced consecutive outbreaks of highly pathogenic avian influenza during the 2020/21 and 2021/22 autumn/winter seasons, resulting in significant mortalities among land- and waterfowl. Understanding the epidemiology and transmission of these viruses in different species is crucial for implementing effective control measures. Infections in different species can range from mild or asymptomatic to severe cases with high morbidity and mortality rates. Defining disease outcomes in different species is essential for understanding their role in the maintenance and transmission of these pathogens.

VIRUSES-BASEL (2022)

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Article Pharmacology & Pharmacy

Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2018-2020

Elena A. Govorkova et al.

Summary: Global analysis showed low susceptibility of influenza viruses to neuraminidase inhibitors (NAIs) and the polymerase acidic (PA) inhibitor baloxavir. NA-H275Y substitution in A(H1N1)pdm09 viruses conferred high resistance to oseltamivir and peramivir. Baloxavir showed reduced susceptibility in a small percentage of viruses, with Japan having a higher rate. Overall, NAIs and baloxavir remain appropriate choices for treating influenza virus infections.

ANTIVIRAL RESEARCH (2022)

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Article Infectious Diseases

Comparison of the safety and immunogenicity of a novel Matrix-M-adjuvanted nanoparticle influenza vaccine with a quadrivalent seasonal influenza vaccine in older adults: a phase 3 randomised controlled trial

Vivek Shinde et al.

Summary: The study aimed to compare the immunological responses of the Matrix-M-adjuvanted quadrivalent nanoparticle influenza vaccine (qNIV) with a licensed, standard-dose quadrivalent inactivated influenza vaccine (IIV4) in older adults. The results showed that qNIV was immunologically non-inferior to IIV4, well tolerated, and produced enhanced immune responses in older adults, indicating potential effectiveness in seasonal influenza vaccination.

LANCET INFECTIOUS DISEASES (2022)

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Article Veterinary Sciences

Gross pathology associated with highly pathogenic avian influenza H5N8 and H5N1 in naturally infected birds in the UK (2020-2021)

Fabian Z. X. Lean et al.

Summary: This study documents the pathology of poultry species and captive birds naturally infected with H5N8 and H5N1 HPAIV between October 2020 and April 2021. The results show that pancreatic necrosis and splenic necrosis were commonly observed in infected poultry, with other less common lesions including cardiac petechiae, serosal hemorrhages, and ascites.

VETERINARY RECORD (2022)

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Article Multidisciplinary Sciences

Unique binding pattern for a lineage of human antibodies with broad reactivity against influenza A virus

Xiaoyu Sun et al.

Summary: Researchers have identified a lineage of broadly neutralizing antibodies that can neutralize different strains of influenza virus. These antibodies neutralize different strains by binding to different epitopes, suggesting an evolutionary adaptation to different viral strains.

NATURE COMMUNICATIONS (2022)

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Article Immunology

Novel H5N6 reassortants bearing the clade 2.3.4.4b HA gene of H5N8 virus have been detected in poultry and caused multiple human infections in China

Wenli Gu et al.

Summary: This study analyzed 15 H5N6 viruses isolated from poultry and seven H5N6 viruses isolated from humans, and found that they formed seven different genotypes derived from H5N8 viruses, domestic duck H5N6 viruses, and other previously circulating viruses in China. Two of these genotypes have caused human infections in multiple provinces.

EMERGING MICROBES & INFECTIONS (2022)

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Article Immunology

Randomized, Double-Blind, Reference-Controlled, Phase 2a Study Evaluating the Immunogenicity and Safety of OVX836, A Nucleoprotein-Based Influenza Vaccine

Isabel Leroux-Roels et al.

Summary: OVX836, a vaccine targeting influenza nucleoprotein, demonstrated safety and immunogenicity in a Phase 1 study. It outperformed the reference vaccine in terms of immunological parameters related to nucleoprotein and showed potential in reducing influenza-like illness episodes.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes

Claudia P. Arevalo et al.

Summary: It is important to develop a vaccine that can provide cross-reactive and subtype-specific antibodies as seasonal influenza vaccines offer limited protection against pandemic influenza virus strains. This study developed a multivalent vaccine using nucleoside-modified mRNA encoding hemagglutinin antigens from all known influenza virus subtypes, which elicited high levels of antibodies in mice and ferrets that reacted to multiple antigens. Vaccination with this mRNA vaccine protected mice and ferrets from both matched and mismatched viral strains.

SCIENCE (2022)

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Article Multidisciplinary Sciences

A universal influenza mRNA vaccine candidate boosts T cell responses and reduces zoonotic influenza virus disease in ferrets

Koen van de Ven et al.

Summary: This study evaluated a novel T cell-inducing nucleoside-modified messenger RNA (mRNA) vaccine that encoded conserved proteins of an H1N1 influenza virus, and found that it induced broadly reactive T cells and enhanced protection against potential influenza viruses.

SCIENCE ADVANCES (2022)

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Article Immunology

Global dissemination of H5N1 influenza viruses bearing the clade 2.3.4.4b HA gene and biologic analysis of the ones detected in China

Pengfei Cui et al.

Summary: H5N1 avian influenza viruses carrying the clade 2.3.4.4b hemagglutinin gene have been circulating widely in wild birds and causing significant poultry loss worldwide. China has identified 13 H5N1 virus isolates and found genetic relationships with globally circulating strains, forming 16 genotypes. These Chinese isolates exhibit different pathogenicity in mice and show antigenic similarity to the currently used vaccine strain in China.

EMERGING MICROBES & INFECTIONS (2022)

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Article Immunology

A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine

Jeeva Subbiah et al.

Summary: A new chimeric protein vaccine called M2e-H3 stalk has been developed to overcome the low efficacy of monomeric domain-based universal vaccines. The vaccine was found to be effective in inducing immune responses and providing protection against various subtypes of influenza viruses in mice, making it a potential candidate for a universal influenza A virus vaccine for both young and aged populations.

NPJ VACCINES (2022)

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Article Multidisciplinary Sciences

Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses

Tingting Li et al.

Summary: Influenza A viruses are a significant global threat, and this study has identified a chimeric monoclonal antibody, C12H5, that offers broad neutralization against H1N1 and H5N1 viruses. The antibody targets a specific epitope on the surface glycoprotein of the virus, leading to control of virus entry and egress. This discovery could have implications for the development of antiviral drugs and broad-protection vaccines against influenza.

NATURE COMMUNICATIONS (2022)

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Article Biology

Insights into binding molecular mechanism of hemagglutinin H3N2 of influenza virus complexed with arbidol and its derivative: A molecular dynamics simulation perspective

Thitiya Boonma et al.

Summary: This study investigated the molecular binding mechanism of arbidol and its derivative with HA of H3N2 influenza virus. The results showed that the derivative could form stronger hydrogen bonds with HA amino acids compared to arbidol, resulting in higher inhibitory potency.

COMPUTATIONAL BIOLOGY AND CHEMISTRY (2022)

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Article Immunology

Intercontinental Spread of Eurasian Highly Pathogenic Avian Influenza A(H5N1) to Senegal

Fatou T. Lo et al.

Summary: In January 2021, the emergence of highly pathogenic avian influenza virus A(H5N1) was reported in Senegal, detected on a poultry farm and in great white pelicans in the Djoudj National Bird Sanctuary. This provides evidence of new transcontinental spread of H5N1 from Europe to Africa.

EMERGING INFECTIOUS DISEASES (2022)

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Article Biochemistry & Molecular Biology

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

Raffael Nachbagauer et al.

Summary: New influenza virus vaccines based on chimeric hemagglutinin have been found to induce a broad, strong, durable and functional immune response targeting the conserved stalk of the hemagglutinin protein. This suggests that these chimeric hemagglutinins have the potential to be developed as universal vaccines that protect broadly against influenza viruses.

NATURE MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Antivirals with common targets against highly pathogenic viruses

Lu Lu et al.

Summary: Throughout history, emerging viruses have constantly appeared and have resulted in millions of human deaths. Climate change and globalization have now created favorable conditions for viral transmission. Thus, the development of effective antivirals, particularly those targeting conserved proteins in multiple unrelated viruses, is urgently needed to combat future emerging and re-emerging viruses.

CELL (2021)

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Article Multidisciplinary Sciences

Quadrivalent influenza nanoparticle vaccines induce broad protection

Seyhan Boyoglu-Barnum et al.

Summary: Computational design of nanoparticle immunogens can induce potent and broad antibody responses against diverse influenza viruses, including neutralizing antibody responses to vaccine-matched strains and broadly protective antibody responses to heterologous viruses. These novel vaccines have the potential to replace traditional seasonal vaccines.

NATURE (2021)

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Article Multidisciplinary Sciences

Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models

Makoto Saito et al.

Summary: Researchers have developed a class of macrocyclic peptides named iHA, which can bind the influenza viral envelope protein hemagglutinin and inhibit virus infection by blocking adsorption and fusion. Particularly, iHA-100 shows powerful efficacy in inhibiting the growth of highly pathogenic influenza viruses and preventing severe pneumonia at later stages of infection in mouse and non-human primate cynomolgus macaque models, indicating its potential as a next-generation, mid-sized biomolecule.

NATURE COMMUNICATIONS (2021)

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Article Virology

Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N8) Virus in Pakistani Live Bird Markets Reveals Rapid Diversification of Clade 2.3.4.4b Viruses

Muzaffar Ali et al.

Summary: Highly pathogenic H5N1 avian influenza viruses have undergone reassortment since 2008, leading to the emergence of H5Nx variants; H5N8 viruses detected in Pakistan were closely related to Saudi Arabia viruses, likely introduced through cross-border transmission; Strengthened surveillance in live bird markets is necessary to monitor for potential A(H5Nx) variants from poultry populations.

VIRUSES-BASEL (2021)

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Letter Immunology

Emerging highly pathogenic avian influenza (H5N8) virus in migratory birds in Central China, 2020

Jiasong Xiong et al.

Summary: The study identified eleven highly pathogenic avian influenza H5N8 viruses that were detected in migratory birds in Central China between November and December 2020. These strains were found to be highly homologous to those isolated in Europe from October to December 2020, suggesting a possible spread from Siberia via migratory birds. The research also revealed that H5N8 virus infection in migratory birds could lead to severe pathological damage and high viral load in multiple organs.

EMERGING MICROBES & INFECTIONS (2021)

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Review Biotechnology & Applied Microbiology

Next-generation influenza vaccines: opportunities and challenges

Chih-Jen Wei et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Review Pharmacology & Pharmacy

Favipiravir, an anti-influenza drug against life-threatening RNA virus infections

Kimiyasu Shiraki et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Article Multidisciplinary Sciences

Pulmonary surfactant-biomimetic nanoparticles potentiate heterosubtypic influenza immunity

Ji Wang et al.

SCIENCE (2020)

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Review Immunology

Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season

Chao Jiang et al.

MICROBES AND INFECTION (2020)

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Article Biotechnology & Applied Microbiology

A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice

Alec W. Freyn et al.

MOLECULAR THERAPY (2020)

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Article Multidisciplinary Sciences

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

Hanjun Zhao et al.

NATURE COMMUNICATIONS (2020)

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Article Agriculture, Multidisciplinary

Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens

Zeng Xian-ying et al.

JOURNAL OF INTEGRATIVE AGRICULTURE (2020)

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Article Immunology

Outbreaks of Highly Pathogenic Avian Influenza (H5N6) Virus Subclade 2.3.4.4h in Swans, Xinjiang, Western China, 2020

Yanbing Li et al.

EMERGING INFECTIOUS DISEASES (2020)

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Review Microbiology

The Emergence and Decennary Distribution of Clade 2.3.4.4 HPAI H5Nx

Khristine Joy C. Antigua et al.

MICROORGANISMS (2019)

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Article Immunology

OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes

Judith Del Campo et al.

NPJ VACCINES (2019)

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Article Biochemistry & Molecular Biology

Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies

Yao-Qing Chen et al.

CELL (2018)

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Review Immunology

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines

Giuseppe Del Giudice et al.

SEMINARS IN IMMUNOLOGY (2018)

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Review Biotechnology & Applied Microbiology

Adjuvanted influenza vaccines

John S. Tregoning et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)

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Article Microbiology

Rapid Evolution of H7N9 Highly Pathogenic Viruses that Emerged in China in 2017

Jianzhong Shi et al.

CELL HOST & MICROBE (2018)

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Article Multidisciplinary Sciences

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

Norbert Pardi et al.

NATURE COMMUNICATIONS (2018)

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Article Immunology

Transmission Dynamics of Highly Pathogenic Avian Influenza Virus A(H5Nx) Clade 2.3.4.4, North America, 2014-2015

Dong-Hun Lee et al.

EMERGING INFECTIOUS DISEASES (2018)

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Article Multidisciplinary Sciences

Adenovirus vector-based multi-epitope vaccine provides partial protection against H5, H7, and H9 avian influenza viruses

Ahmed O. Hassan et al.

PLOS ONE (2017)

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Review Infectious Diseases

Universal influenza virus vaccines and therapeutic antibodies

R. Nachbagauer et al.

CLINICAL MICROBIOLOGY AND INFECTION (2017)

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Article Virology

Highly pathogenic influenza H5N1 virus of clade 2.3.2.1c in Western Siberia

V. Y. Marchenko et al.

ARCHIVES OF VIROLOGY (2016)

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Article Multidisciplinary Sciences

Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies

Michael Schotsaert et al.

SCIENTIFIC REPORTS (2016)

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Article Virology

Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014-2015

Yuhai Bi et al.

VIROLOGICA SINICA (2016)

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Article Infectious Diseases

Emergence of a novel cluster of influenza A(H5N1) virus clade 2.2.1.2 with putative human health impact in Egypt, 2014/15

A. S. Arafa et al.

EUROSURVEILLANCE (2015)

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Article Biotechnology & Applied Microbiology

Outbreaks of highly pathogenic avian influenza H5N1 clade 2.3.2.1c in hunting falcons and kept wild birds in Dubai implicate intercontinental virus spread

Mahmoud M. Naguib et al.

JOURNAL OF GENERAL VIROLOGY (2015)

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Article Virology

A Novel Humanized Antibody Neutralizes H5N1 Influenza Virus via Two Different Mechanisms

Yunrui Tan et al.

JOURNAL OF VIROLOGY (2015)

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Article Immunology

Genetic and antigenic characterization of H5N1 viruses of clade 2.3.2.1 isolated in India

Sushant Bhat et al.

MICROBIAL PATHOGENESIS (2015)

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Review Biotechnology & Applied Microbiology

Advances in the development of influenza virus vaccines

Florian Krammer et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

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Article Multidisciplinary Sciences

Avian influenza H5N1 viral and bird migration networks in Asia

Huaiyu Tian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Microbiology

Fitness Costs for Influenza B Viruses Carrying Neuraminidase Inhibitor- Resistant Substitutions: Underscoring the Importance of E119A and H274Y

Andrew J. Burnham et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

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Article Infectious Diseases

Revised and updated nomenclature for highly pathogenic avian influenza A (H5N1) viruses

Gavin J. D. Smith et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2014)

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Article Virology

New Small Molecule Entry Inhibitors Targeting Hemagglutinin-Mediated Influenza A Virus Fusion

Arnab Basu et al.

JOURNAL OF VIROLOGY (2014)

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Review Biotechnology & Applied Microbiology

Avian influenza vaccines against H5N1 'bird flu'

Chengjun Li et al.

TRENDS IN BIOTECHNOLOGY (2014)

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Article Immunology

Novel Reassortant Influenza A(H5N8) Viruses in Domestic Ducks, Eastern China

Haibo Wu et al.

EMERGING INFECTIOUS DISEASES (2014)

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Article Multidisciplinary Sciences

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

Xiao-Dong Li et al.

SCIENCE (2013)

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Article Microbiology

Characterization of three H5N5 and one H5N8 highly pathogenic avian influenza viruses in China

Kunkun Zhao et al.

VETERINARY MICROBIOLOGY (2013)

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Article Virology

Multiple amino acid mutations in viral RNA polymerase may synergistically enhance the transmissibility and/or virulence of the 2009 pandemic influenza (H1N1) virus

X. Wang et al.

ACTA VIROLOGICA (2013)

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Article Biochemistry & Molecular Biology

A novel peptide inhibits the influenza virus replication by preventing the viral attachment to the host cells

Mohamed Rajik et al.

International Journal of Biological Sciences (2012)

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Theoretical Studies on the Susceptibility of Oseltamivir against Variants of 2009 A/H1N1 Influenza Neuraminidase

Lin Li et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

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Article Biotechnology & Applied Microbiology

A novel family of peptides with potent activity against influenza A viruses

Marlynne Q. Nicol et al.

JOURNAL OF GENERAL VIROLOGY (2012)

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Article Virology

Residue Y161 of Influenza Virus Hemagglutinin Is Involved in Viral Recognition of Sialylated Complexes from Different Hosts

Minxiu Wang et al.

JOURNAL OF VIROLOGY (2012)

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Article Pharmacology & Pharmacy

Aprotinin and similar protease inhibitors as drugs against influenza

O. P. Zhirnov et al.

ANTIVIRAL RESEARCH (2011)

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A computationally optimized broadly reactive antigen (COBRA) based H5N1 VLP vaccine elicits broadly reactive antibodies in mice and ferrets

Brendan M. Giles et al.

VACCINE (2011)

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Article Microbiology

Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt

Yohei Watanabe et al.

PLOS PATHOGENS (2011)

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Article Microbiology

Acid Stability of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Pathogenicity

Rebecca M. DuBois et al.

PLOS PATHOGENS (2011)

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Article Immunology

Effect of the Neuraminidase Mutation H274Y Conferring Resistance to Oseltamivir on the Replicative Capacity and Virulence of Old and Recent Human Influenza A(H1N1) Viruses

Mariana Baz et al.

JOURNAL OF INFECTIOUS DISEASES (2010)

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Article Virology

Glycosylation at 158N of the Hemagglutinin Protein and Receptor Binding Specificity Synergistically Affect the Antigenicity and Immunogenicity of a Live Attenuated H5N1 A/Vietnam/1203/2004 Vaccine Virus in Ferrets

Weijia Wang et al.

JOURNAL OF VIROLOGY (2010)

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Article Virology

In Vitro Assessment of Attachment Pattern and Replication Efficiency of H5N1 Influenza A Viruses with Altered Receptor Specificity

Salin Chutinimitkul et al.

JOURNAL OF VIROLOGY (2010)

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Letter Medicine, General & Internal

Emergence of a Multidrug-Resistant Pandemic Influenza A (H1N1) Virus.

Erhard van der Vries et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Article Immunology

Avian influenza vaccines and therapies for poultry

David E. Swayne

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES (2009)

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Article Virology

Identification and characterisation of a novel anti-viral peptide against avian influenza virus H9N2

Mohamed Rajik et al.

VIROLOGY JOURNAL (2009)

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Article Biochemistry & Molecular Biology

Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity

James Stevens et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

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Article Microbiology

Human-like receptor specificity does not affect the neuraminidase-inhibitor susceptibility of H5N1 influenza viruses

Natalia A. Ilyushina et al.

PLOS PATHOGENS (2008)

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Article Immunology

DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infection

Jessica A. Belser et al.

JOURNAL OF INFECTIOUS DISEASES (2007)

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Article Virology

An avian influenza H5N1 virus that binds to a human-type receptor

Prasert Auewarakul et al.

JOURNAL OF VIROLOGY (2007)

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Article Multidisciplinary Sciences

Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity

Zhi-Yong Yang et al.

SCIENCE (2007)

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Article Biotechnology & Applied Microbiology

Molecular and antigenic evolution and geographical spread of H5N1 highly pathogenic avian influenza viruses in western Africa

M. F. Ducatez et al.

JOURNAL OF GENERAL VIROLOGY (2007)

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Review Pharmacology & Pharmacy

Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention

Erik De Clereq et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

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Article Veterinary Sciences

Avian influenza virus screening in wild waterfowl in Norway, 2005

Christine Monceyron Jonassen et al.

AVIAN DISEASES (2007)

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Article Virology

Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells

Jeremy C. Jones et al.

JOURNAL OF VIROLOGY (2006)

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Review Biotechnology & Applied Microbiology

Antiviral agents active against influenza A viruses

Erik De Clercq

NATURE REVIEWS DRUG DISCOVERY (2006)

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Article Multidisciplinary Sciences

Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors

Shinya Yamada et al.

NATURE (2006)

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Article Multidisciplinary Sciences

Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus

J Stevens et al.

SCIENCE (2006)

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Article Medicine, General & Internal

Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States

RA Bright et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)

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Article Immunology

Analysis of epitope recognition of antibodies induced by DNA immunization against hemagglutinin protein of influenza A virus

K Tonegawa et al.

VACCINE (2003)

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Potential cross-species transmission of highly pathogenic avian influenza H5 subtype (HPAI H5) viruses to humans calls for the development of H5-specific and universal influenza vaccines

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