☆ 4.6 Review

Targeting Autophagy Using Long Non-Coding RNAs (LncRNAs): New Landscapes in the Arena of Cancer Therapeutics

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LncRNA NEAT1 promotes autophagy via regulating miR-204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma

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Cell-intrinsic survival signals. The role of autophagy in metastatic dissemination and tumor cell dormancy

Laura Vera-Ramirez

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SNHG14 stimulates cell autophagy to facilitate cisplatin resistance of colorectal cancer by regulating miR-186/ATG14 axis

Yi Han et al.

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Potential regulatory role of lncRNA-miRNA-mRNA axis in osteosarcoma

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Long non-coding RNA UCA1 promotes autophagy by targeting miR-96-5p in acute myeloid leukaemia

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Long non-coding RNA PRRT3-AS1 silencing inhibits prostate cancer cell proliferation and promotes apoptosis and autophagy

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Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review

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LncRNA SNHG11 Promotes Proliferation, Migration, Apoptosis, and Autophagy by Regulating hsa-miR-184/AGO2 in HCC

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Long Noncoding RNA TUG I Promotes Autophagy-Associated Paclitaxel Resistance by Sponging miR-29b-3p in Ovarian Cancer Cells

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The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma

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LncRNA NEAT1 knockdown attenuates autophagy to elevate 5-FU sensitivity in colorectal cancer via targeting miR-34a

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Calebin A Potentiates the Effect of 5-FU and TNF-β (Lymphotoxin α) against Human Colorectal Cancer Cells: Potential Role of NF-κB

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Long noncoding RNAs in osteosarcoma via various signaling pathways

Jinming Han et al.

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LncRNA DANCR-miR-758-3p-PAX6 Molecular Network Regulates Apoptosis and Autophagy of Breast Cancer Cells

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Iron Oxide Nanoparticle-Induced Autophagic Flux Is Regulated by Interplay between p53-mTOR Axis and Bcl-2 Signaling in Hepatic Cells

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Long non-coding RNA LINC00858 inhibits colon cancer cell apoptosis, autophagy, and senescence by activating WNK2 promoter methylation

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Mechanistic Involvement of Long Non-Coding RNAs in Oncotherapeutics Resistance in Triple-Negative Breast Cancer

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Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer

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Autophagy as a Potential Therapy for Malignant Glioma

Angel Escamilla-Ramirez et al.

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LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

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Long non-coding RNA growth arrest-specific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer

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lncRNA UCA1 Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells Through miR-23b-3p/ZNF281 Axis

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Long Non-Coding RNA TUG1 Promotes Cell Proliferation and Inhibits Cell Apoptosis, Autophagy in Clear Cell Renal Cell Carcinoma via MiR-31-5p/ FLOT1 Axis

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DUSP5 (dual-specificity protein phosphatase 5) suppresses BCG-induced autophagy via ERK 1/2 signaling pathway

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LINC01572 Regulates Cisplatin Resistance in Gastric Cancer Cells by Mediating miR-497-5p

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Linc-RA1 inhibits autophagy and promotes radioresistance by preventing H2Bub1/USP44 combination in glioma cells

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LINC00857 Interacting with YBX1 to Regulate Apoptosis and Autophagy via MET and Phosphor-AMPKa Signaling

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The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity

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Long Non-Coding RNA SNHG1 Regulates the Wnt/β-Catenin and PI3K/AKT/mTOR Signaling Pathways via EZH2 to Affect the Proliferation, Apoptosis, and Autophagy of Prostate Cancer Cell

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Autophagy and liver cancer

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The implication of long non-coding RNAs in the diagnosis, pathogenesis and drug resistance of pancreatic ductal adenocarcinoma and their possible therapeutic potential

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Bladder Cancer: A Review

Andrew T. Lenis et al.

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Inflection of Akt/mTOR/STAT-3 cascade in TNF-α induced protein 8 mediated human lung carcinogenesis

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Study on Clinical Significance of LncRNA EGOT Expression in Colon Cancer and Its Effect on Autophagy of Colon Cancer Cells

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LncRNAs in Non-Small-Cell Lung Cancer

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Silvia Vega-Rubin-de-Celis

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Long noncoding RNA PANDAR inhibits the development of lung cancer by regulating autophagy and apoptosis pathways

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Retinoblastoma, the visible CNS tumor: A review

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SNHG14 enhances gemcitabine resistance by sponging miR-101 to stimulate cell autophagy in pancreatic cancer

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The PVT1/miR-216b/Beclin-1 regulates cisplatin sensitivity of NSCLC cells via modulating autophagy and apoptosis

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The expanding roles of long non-coding RNAs in the regulation of cancer stem cells

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The relationship between autophagy and the immune system and its applications for tumor immunotherapy

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Induction of the Epithelial-to-Mesenchymal Transition of Human Colorectal Cancer by Human TNF-β (Lymphotoxin) and its Reversal by Resveratrol

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Silencing of SNHG6 induced cell autophagy by targeting miR-26a-5p/ULK1 signaling pathway in human osteosarcoma

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Cancer drug development: The missing links

Ajaikumar B. Kunnumakkara et al.

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Long non-coding RNA PVT1 promotes autophagy as ceRNA to target ATG3 by sponging microRNA-365 in hepatocellular carcinoma

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Silencing of long noncoding RNA RP11-476D10.1 enhances apoptosis and autophagy while inhibiting proliferation of papillary thyroid carcinoma cells via microRNA-138-5p-dependent inhibition of LRRK2

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Downregulation of LINC00460 decreases STC2 and promotes autophagy of head and neck squamous cell carcinoma by up-regulating microRNA-206

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Long non-coding RNA LINC01207 silencing suppresses AGR2 expression to facilitate autophagy and apoptosis of pancreatic cancer cells by sponging miR-143-5p

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lncRNA KCNQ1OT1 enhances the chemoresistance of oxaliplatin in colon cancer by targeting the miR-34a/ATG4B pathway

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LncRNA SLCO4A1-AS1 promotes colorectal cancer cell proliferation by enhancing autophagy via miR-508-3p/PARD3 axis

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Autophagy-Independent Functions of the Autophagy Machinery

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Long non-coding RNA Malat1 activated autophagy, hence promoting cell proliferation and inhibiting apoptosis by sponging miR-101 in colorectal cancer

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LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathway

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LncRNA CCAT1 promotes autophagy via regulating ATG7 by sponging miR-181 in hepatocellular carcinoma

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The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy

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A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy

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LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells

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LncRNA MCM3AP-AS1 Regulates Epidermal Growth Factor Receptor and Autophagy to Promote Hepatocellular Carcinoma Metastasis by Interacting with miR-455

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Long noncoding RNA HAGLROS promotes cell proliferation, inhibits apoptosis and enhances autophagy via regulating miR-5095/ATG12 axis in hepatocellular carcinoma cells

Huamei Wei et al.

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METase/lncRNA HULC/FoxM1 reduced cisplatin resistance in gastric cancer by suppressing autophagy

Lin Xin et al.

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Long non-coding RNA: Classification, biogenesis and functions in blood cells

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LncRNA-ATB promotes autophagy by activating Yes-associated protein and inducing autophagy-related protein 5 expression in hepatocellular carcinoma

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Targeting Autophagy in Cancer: Recent Advances and Future Directions

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Long Non-Coding RNA in the Pathogenesis of Cancers

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Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition

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Hematological malignancies and molecular targeting therapy

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Evidence That Calebin A, a Component of Curcuma Longa Suppresses NF-κB Mediated Proliferation, Invasion and Metastasis of Human Colorectal Cancer Induced by TNF-β (Lymphotoxin)

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Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

Jean M. Mulcahy Levy et al.

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Long noncoding RNA growth arrest-specific 5 facilitates glioma cell sensitivity to cisplatin by suppressing excessive autophagy in an mTOR-dependent manner

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Long noncoding RNA UCA1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition

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Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma

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TIPE2 Induced the Proliferation, Survival, and Migration of Lung Cancer Cells Through Modulation of Akt/mTOR/NF-κB Signaling Cascade

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The long non-coding RNA H19 induces hypoxia/reoxygenation injury by up-regulating autophagy in the hepatoma carcinoma cells

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MiR-19a Affects Hepatocyte Autophagy via Regulating lncRNA NBR2 and AMPK/PPAR in D-GalN/Lipopolysaccharide-Stimulated Hepatocytes

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LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1α

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LncRNA DICER1-AS1 promotes the proliferation, invasion and autophagy of osteosarcoma cells via miR-30b/ATG5

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Upregulation of CASC2 sensitized glioma to temozolomide cytotoxicity through autophagy inhibition by sponging miR-193a-5p and regulating mTOR expression

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LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells

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Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling

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Emerging roles of long non-coding RNA in cancer

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LncRNA LCPAT1 Mediates Smoking/Particulate Matter 2.5-Induced Cell Autophagy and Epithelial-Mesenchymal Transition in Lung Cancer Cells via RCC2

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MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation

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STAT3-induced lncRNA HAGLROS overexpression contributes to the malignant progression of gastric cancer cells via mTOR signal-mediated inhibition of autophagy

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Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a

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LINC00470 Coordinates the Epigenetic Regulation of ELFN2 to Distract GBM Cell Autophagy

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The coming of age of chaperone-mediated autophagy

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Mechanism and medical implications of mammalian autophagy

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Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy

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The Roles of Autophagy in Cancer

Chul Won Yun et al.

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Long non-coding RNA MEG3 regulates proliferation, apoptosis, and autophagy and is associated with prognosis in glioma

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Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy

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Role of lncRNA and EZH2 Interaction/Regulatory Network in Lung Cancer

Min Su et al.

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A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFα by abrogating NF-κB activation cascade

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Recent development of targeted approaches for the treatment of breast cancer

V. L. Maruthanila et al.

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LncRNA H19 inhibits autophagy by epigenetically silencing of DIRAS3 in diabetic cardiomyopathy

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LincRNA-p21 knockdown enhances radiosensitivity of hypoxic tumor cells by reducing autophagy through HIF-1/Akt/mTOR/P70S6K pathway

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The Long Noncoding RNA HOTAIR in Breast Cancer: Does Autophagy Play a Role?

Elzbieta Pawlowska et al.

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New Insights into the Role of Autophagy in Tumor Immune Microenvironment

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LncRNA MALAT-1 Elevates HMGB1 to Promote Autophagy Resulting in Inhibition of Tumor Cell Apoptosis in Multiple Myeloma

Da Gao et al.

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Wanted DEAD/H or Alive: Helicases Winding Up in Cancers

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Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer

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The Diversity of Long Noncoding RNAs and Their Generation

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Inhibition of long non-coding RNA ROR reverses resistance to Tamoxifen by inducing autophagy in breast cancer

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Long non-coding RNAs in osteosarcoma

Ruiling Chen et al.

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Long non-coding RNA CTA sensitizes osteosarcoma cells to doxorubicin through inhibition of autophagy

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Upregulation of the lncRNA Meg3 induces autophagy to inhibit tumorigenesis and progression of epithelial ovarian carcinoma by regulating activity of ATG3

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Wanted DEAD/H or Alive: Helicases Winding Up in Cancers

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Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA

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Uveal melanoma: epidemiology, etiology, and treatment of primary disease

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Pediatric osteosarcoma: An updated review

Shachi Jain Taran et al.

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Malatl activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma

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LncRNA SNHG15 contributes to proliferation, invasion and autophagy in osteosarcoma cells by sponging miR-141

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Long non-coding RNA AC023115.3 suppresses chemoresistance of glioblastoma by reducing autophagy

Binbin Ma et al.

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Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer

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PM2.5 exposure-induced autophagy is mediated by lncRNA loc146880 which also promotes the migration and invasion of lung cancer cells

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Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence

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PCGEM1 stimulates proliferation of osteoarthritic synoviocytes by acting as a sponge for miR-770

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Long non-coding RNA HNF1A-AS1 functioned as an oncogene and autophagy promoter in hepatocellular carcinoma through sponging hsa-miR-30b-5p

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Targeting autophagy to sensitive glioma to temozolomide treatment

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The long noncoding RNA HOTAIR activates autophagy by upregulating ATG3 and ATG7 in hepatocellular carcinoma

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Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy

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LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress

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Unique features of long non-coding RNA biogenesis and function

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Long noncoding RNA Chast promotes cardiac remodeling

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Large intergenic non-coding RNA-ROR reverses Gemcitabine-induced autophagy and apoptosis in breast cancer cells

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Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer

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An artificial lncRNA targeting multiple miRNAs overcomes sorafenib resistance in hepatocellular carcinoma cells

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A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells

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How the Atg1 complex assembles to initiate autophagy

Christopher W. Davies et al.

AUTOPHAGY (2015)

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Article Engineering, Biomedical

Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation

Chiu-Ling Chen et al.

BIOMATERIALS (2015)

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Article Biochemistry & Molecular Biology

PLEKHM1 Regulates Autophagosome-Lysosome Fusion through HOPS Complex and LC3/GABARAP Proteins

David G. McEwan et al.

MOLECULAR CELL (2015)

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Review Biochemistry & Molecular Biology

An Overview of Autophagy: Morphology, Mechanism, and Regulation

Katherine R. Parzych et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

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Editorial Material Cell Biology

BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy

Lisa M. Lindqvist et al.

AUTOPHAGY (2014)

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Editorial Material Cell Biology

Atg1 kinase organizes autophagosome formation by phosphorylating Atg9

Daniel Papinski et al.

AUTOPHAGY (2014)

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Review Oncology

Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention

Parisa Karimi et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2014)

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Review Oncology

The Four Faces of Autophagy: Implications for Cancer Therapy

David A. Gewirtz

CANCER RESEARCH (2014)

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Review Cell Biology

Historical landmarks of autophagy research

Yoshinori Ohsumi

CELL RESEARCH (2014)

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Review Cell Biology

The machinery of macroautophagy

Yuchen Feng et al.

CELL RESEARCH (2014)

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Review Cell Biology

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

David Heras-Sandoval et al.

CELLULAR SIGNALLING (2014)

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Article Genetics & Heredity

Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

Kanjoormana A. Manu et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2014)

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Article Orthopedics

A Long Non-Coding RNA, GAS5, Plays a Critical Role in the Regulation of miR-21 During Osteoarthritis

Jinsoo Song et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2014)

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Article Oncology

Pseudogene PTENP1 Functions as a Competing Endogenous RNA to Suppress Clear-Cell Renal Cell Carcinoma Progression

Gan Yu et al.

MOLECULAR CANCER THERAPEUTICS (2014)

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Review Cell Biology

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

E. A. Dunlop et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2014)

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Article Oncology

BRAF-activated long non-coding RNA contributes to cell proliferation and activates autophagy in papillary thyroid carcinoma

Yong Wang et al.

ONCOLOGY LETTERS (2014)

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Review Oncology

Ras and autophagy in cancer development and therapy

Eran Schmukler et al.

ONCOTARGET (2014)

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Article Biochemistry & Molecular Biology

Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer

Liang Ying et al.

MOLECULAR BIOSYSTEMS (2013)

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Editorial Material Biochemistry & Molecular Biology

Paraspeckle formation during the biogenesis of long non-coding RNAs

Takao Naganuma et al.

RNA BIOLOGY (2013)

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Article Pathology

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

Lyndsay Murrow et al.

Annual Review of Pathology-Mechanisms of Disease (2012)

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Review Biochemistry & Molecular Biology

Microautophagy: lesser-known self-eating

Wen-wen Li et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

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Article Oncology

Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets

Ajaikumar B. Kunnumakkara et al.

INTERNATIONAL JOURNAL OF CANCER (2012)

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Review Oncology

Deconvoluting the context-dependent role for autophagy in cancer

Eileen White

NATURE REVIEWS CANCER (2012)

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Review Cell Biology

The Role of Atg Proteins in Autophagosome Formation

Noboru Mizushima et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

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Article Cell Biology

Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein

Zhuo Wang et al.

AUTOPHAGY (2011)

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Review Oncology

Role of Autophagy in Cancer Prevention

Hsin-Yi Chen et al.

CANCER PREVENTION RESEARCH (2011)

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Article Medicine, General & Internal

Pancreatic cancer

Audrey Vincent et al.

LANCET (2011)

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Review Cell Biology

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

Maria M. Mihaylova et al.

NATURE CELL BIOLOGY (2011)

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Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

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Article Hematology

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

Pauline Isakson et al.

BLOOD (2010)

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Article Cell Biology

The Beclin 1 interactome

Congcong He et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

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Article Biochemistry & Molecular Biology

Dimeric Coiled-coil Structure of Saccharomyces cerevisiae Atg16 and Its Functional Significance in Autophagy

Yuko Fujioka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Review Biochemistry & Molecular Biology

Autophagy and the Integrated Stress Response

Guido Kroemer et al.

MOLECULAR CELL (2010)

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Editorial Material Cell Biology

Atg14L and Rubicon Yin and yang of Beclin 1-mediated autophagy control

Yun Zhong et al.

AUTOPHAGY (2009)

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Review Cell Biology

Dynamics and diversity in autophagy mechanisms: lessons from yeast

Hitoshi Nakatogawa et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

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Article Cell Biology

LAMP-2 - A control step for phagosome and autophagosome maturation

Paul Saftig et al.

AUTOPHAGY (2008)

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Editorial Material Cell Biology

Autophagy revisited

Daniel J. Klionsky

AUTOPHAGY (2008)

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Article Cell Biology

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

Elizabeth L. Axe et al.

JOURNAL OF CELL BIOLOGY (2008)

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Article Biochemistry & Molecular Biology

In vitro reconstitution of plant ATG8 and ATG12 conjugation systems essential for autophagy

Yuko Fujioka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Biochemistry & Molecular Biology

LAMP proteins are required for fusion of lysosomes with phagosomes

Kassidy K. Huynh et al.

EMBO JOURNAL (2007)

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Review Biochemistry & Molecular Biology

Non-coding RNA

JS Mattick et al.

HUMAN MOLECULAR GENETICS (2006)

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Article Biochemistry & Molecular Biology

The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

K Suzuki et al.

EMBO JOURNAL (2001)

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