4.6 Article

Uncovering Actions of Type 3 Deiodinase in the Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)

Related references

Note: Only part of the references are listed.
Article Food Science & Technology

Oxidized Pork Induces Hepatic Steatosis by Impairing Thyroid Hormone Function in Mice

Yueting Ge et al.

Summary: Recent studies have found that high oxidative injury pork and Dityr intake induce oxidative stress and inflammation, impairing thyroid function and peripheral metabolism, leading to a decrease in circulating and liver thyroid hormones and induced hepatic steatosis.

MOLECULAR NUTRITION & FOOD RESEARCH (2022)

Article Gastroenterology & Hepatology

Advancing the global public health agenda for NAFLD: a consensus statement

Jeffrey Lazarus et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects a significant portion of the global adult population, but has received little attention from the global public health community. This has led to a lack of inclusion of NAFLD in national and international strategies and policies for non-communicable diseases, highlighting the need for a more comprehensive public health response to the disease.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

Article Biochemistry & Molecular Biology

T3-induced enhancement of mitochondrial Ca2+ uptake as a boost for mitochondrial metabolism

Ines Tawfik et al.

Summary: Thyroid hormones regulate mitochondrial Ca2+ uptake, leading to increased energy metabolism and reactive oxygen species production.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Review Endocrinology & Metabolism

Global Prevalence and Clinical Characteristics of Metabolic-associated Fatty Liver Disease: A Meta-Analysis and Systematic Review of 10 739 607 Individuals

Kai En Chan et al.

Summary: This meta-analysis supports previous studies in reporting that MAFLD affects more than a third of the global population. Lean and nonobese MAFLD individuals are significantly associated with metabolic complications such as hypertension and diabetes.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

Article Endocrinology & Metabolism

Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis

Jin Zhou et al.

Summary: This study found that thyroid hormone can treat NASH-associated hepatic inflammation and fibrosis by promoting autophagy and mitochondrial biogenesis, increasing the oxidation of fatty acids, and reducing lipotoxicity, oxidative stress, and inflammation.

THYROID (2022)

Article Biochemistry & Molecular Biology

Modulation of Deiodinase Types 2 and 3 during Skeletal Muscle Regeneration

Ashley Ogawa-Wong et al.

Summary: The expression and activity of deiodinase types 2 and 3 during muscle regeneration are identified. Dio2 is present in PAX7-positive cells and PDGFA-expressing fibro-adipogenic progenitor cells, while Dio3 is detected in MYOD-positive stem cells and macrophages. These findings shed light on the crosstalk and synchronized regulation of T3 in injured muscle mediated by deiodinases and provide insights into potential new treatments for muscular diseases.

METABOLITES (2022)

Article Biochemistry & Molecular Biology

TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD

Andrea Caddeo et al.

Summary: The novel THR beta agonist TG68 demonstrated significant anti-steatogenic effects and improvement of liver injury in mice fed a high-fat diet, without extra-hepatic side effects, suggesting it may be a useful tool for treating NAFLD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Dynamic Control of Mitochondrial Ca2+ Levels as a Survival Strategy of Cancer Cells

Corina T. Madreiter-Sokolowski et al.

Summary: Cancer cells have increased energy demands and maintaining mitochondrial Ca2+ homeostasis is crucial for their survival. The ER-mitochondrial linkage and UCP2 play key roles in the mitochondrial Ca2+ uptake route in cancer cells. Disrupting the balance of these factors can lead to cancer cell death.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Endocrinology & Metabolism

Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression

Eveline Bruinstroop et al.

Summary: The study found that in the early stages of nonalcoholic fatty liver disease, Dio1 gene expression and activity increased, which was associated with an increased T(3)/T-4 ratio. The results suggest that Dio1 regulates hepatic triglyceride content during hepatosteatosis and early nonalcoholic steatohepatitis.

MOLECULAR METABOLISM (2021)

Article Gastroenterology & Hepatology

Effects of Resmetirom on Noninvasive Endpoints in a 36-Week Phase 2 Active Treatment Extension Study in Patients With NASH

Stephen A. Harrison et al.

Summary: The study demonstrated significant improvements in liver fat reduction, lipid metabolism, and fibrosis markers reduction in NASH patients treated with resmetirom for 36 weeks. Resmetirom showed good tolerability and safety in patients with NASH.

HEPATOLOGY COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats

Ana Cristina Roginski et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Review Endocrinology & Metabolism

The interplay between thyroid and liver: implications for clinical practice

E. Piantanida et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2020)

Article Endocrinology & Metabolism

Oxidative remote induction of type 3 deiodinase impacts nonthyroidal illness syndrome

Tatiana Ederich Lehnen et al.

JOURNAL OF ENDOCRINOLOGY (2020)

Article Endocrinology & Metabolism

Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD

Eveline Bruinstroop et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Review Endocrinology & Metabolism

Metabolic Effects of the Intracellular Regulation of Thyroid Hormone: Old Players, New Concepts

Annunziata G. Cicatiello et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Multidisciplinary Sciences

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

G. Sebastian Hoenes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemistry & Molecular Biology

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Zhenyu Zhong et al.

Review Gastroenterology & Hepatology

Non-alcoholic fatty liver disease and cardiovascular risk: Pathophysiological mechanisms and implications

Sven M. Francque et al.

JOURNAL OF HEPATOLOGY (2016)

Article Gastroenterology & Hepatology

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

Ahmed Ghallab et al.

JOURNAL OF HEPATOLOGY (2016)

Review Cardiac & Cardiovascular Systems

A concise review of non-alcoholic fatty liver disease

Nwe Ni Than et al.

ATHEROSCLEROSIS (2015)

Article Cell Biology

3,5-Diiodo-L-Thyronine Modifies the Lipid Droplet Composition in a Model of Hepatosteatosis

Elena Grasselli et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)

Article Endocrinology & Metabolism

N-Acetylcysteine Administration Prevents Nonthyroidal Illness Syndrome in Patients With Acute Myocardial Infarction: A Randomized Clinical Trial

Josi Vidart et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

Review Endocrinology & Metabolism

Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism

Rohit A. Sinha et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)

Review Oncology

Signaling pathways in follicular cell-derived thyroid carcinomas (Review)

Mirian Romitti et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2013)

Article Medicine, Research & Experimental

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

Rohit Anthony Sinha et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Medicine, Research & Experimental

IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells

Simone Magagnin Wajner et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Pharmacology & Pharmacy

Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research

Carol Kilkenny et al.

JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS (2010)

Review Biochemistry & Molecular Biology

Regulation of mitochondrial dehydrogenases by calcium ions

Richard M. Denton

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2009)

Review Biochemistry & Molecular Biology

Capacity of oxidative phosphorylation in human skeletal muscle New perspectives of mitochondrial physiology

Erich Gnaiger

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Article Cell Biology

T3-mediated expression of PGC-1α via a far upstream located thyroid hormone response element

Anne Wulf et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2008)

Article Endocrinology & Metabolism

Thyroid hormone regulates tubulin expression in mammalian liver.: Effects of deleting thyroid hormone receptor-α or -β

CG Vallejo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2005)