Various AAV Serotypes and Their Applications in Gene Therapy: An Overview

Despite scientific discoveries in the field of gene and cell therapy, some diseases still have no effective treatment. Advances in genetic engineering methods have enabled the development of effective gene therapy methods for various diseases based on adeno-associated viruses (AAVs). Today, many AAV-based gene therapy medications are being investigated in preclinical and clinical trials, and new ones are appearing on the market. In this article, we present a review of AAV discovery, properties, different serotypes, and tropism, and a following detailed explanation of their uses in gene therapy for disease of different organs and systems.

Automated summary

Despite the advancements in gene and cell therapy, some diseases still lack effective treatment. Adeno-associated viruses (AAVs) have enabled the development of effective gene therapy methods for various diseases. Numerous AAV-based gene therapy medications are undergoing trials and entering the market. This article provides a review of AAV discovery, properties, serotypes, tropism, and their applications in gene therapy for different diseases of organs and systems.