Journal
CELLS
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/cells12081124
Keywords
glycolysis; tumor initiation; senescence; oncoprotein; DNA repair; chromatin
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Reprogramming of energy production from mitochondrial respiration to glycolysis is a characteristic of cancer. Glycolysis can be upregulated in the early stages of tumorigenesis, as many oncoproteins involved in tumor initiation and progression promote glycolysis. In addition, recent evidence suggests that upregulated glycolysis itself may contribute to tumorigenesis through various mechanisms. This article provides a summary of the role of upregulated glycolysis in tumor initiation and proposes a mechanistic model to explain its involvement.
Reprogramming energy production from mitochondrial respiration to glycolysis is now considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to changes in their microenvironment (e.g., hypoxia, mechanical stress) that are conducive to the upregulation of glycolysis. Over the years, however, it has become clear that glycolysis can also associate with the earliest steps of tumorigenesis. Thus, many of the oncoproteins most commonly involved in tumor initiation and progression upregulate glycolysis. Moreover, in recent years, considerable evidence has been reported suggesting that upregulated glycolysis itself, through its enzymes and/or metabolites, may play a causative role in tumorigenesis, either by acting itself as an oncogenic stimulus or by facilitating the appearance of oncogenic mutations. In fact, several changes induced by upregulated glycolysis have been shown to be involved in tumor initiation and early tumorigenesis: glycolysis-induced chromatin remodeling, inhibition of premature senescence and induction of proliferation, effects on DNA repair, O-linked N-acetylglucosamine modification of target proteins, antiapoptotic effects, induction of epithelial-mesenchymal transition or autophagy, and induction of angiogenesis. In this article we summarize the evidence that upregulated glycolysis is involved in tumor initiation and, in the following, we propose a mechanistic model aimed at explaining how upregulated glycolysis may play such a role.
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