4.6 Article

Engineered Synthetic STxB for Enhanced Cytosolic Delivery

Related references

Note: Only part of the references are listed.
Article Food Science & Technology

STxB as an Antigen Delivery Tool for Mucosal Vaccination

Eric Tartour et al.

Summary: Immunotherapy holds great promise for treating cancer and infectious diseases with high efficacy and minimal side effects. However, there is still a lack of mucosal vaccines to protect against tumors or infections affecting the upper airways or lungs. This review focuses on the B-subunit of Shiga toxin (STxB) as a potential mucosal vaccine candidate and compares it to other immunotherapy vectors. STxB has shown to induce humoral immunity and cellular immune responses, including CD4(+) and CD8(+) T lymphocytes, against tumor and viral antigens. Furthermore, STxB-based vaccines have demonstrated the ability to induce mucosal IgA and resident memory CD8(+) T cells when administered nasal route. The review also highlights the potential synergy between STxB-based vaccines and other therapeutic modalities in preclinical cancer models. The unique molecular characteristics of STxB, such as low immunogenicity and cross-species conservation of its target molecule, contribute to its competitive advantage among other dendritic cell targeting approaches. In conclusion, STxB appears as an original and innovative tool for the development of mucosal vaccines against infectious diseases and cancer.

TOXINS (2022)

Article Oncology

CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors

Soumaya Karaki et al.

Summary: This study demonstrates the in vivo role of the CXCR6-CXCL16 axis in the migration of CD8(+) resident memory T cells in lung mucosa after intranasal vaccination, leading to tumor growth control. Intranasal vaccination induces higher and more sustained concentrations of CXCL16, compared with other chemokines, showing superior efficacy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Chemistry, Multidisciplinary

Absolute Quantification of Drug Vector Delivery to the Cytosol

Marco Lucchino et al.

Summary: A sensitive and robust assay has been developed for quantifying the relative or absolute numbers of macromolecular drugs in the cytosol, facilitating the optimization of drug delivery vectors and enhancing understanding of the translocation process.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Engineering, Biomedical

The evolution of commercial drug delivery technologies

Ava M. Vargason et al.

Summary: This review article discusses how challenges in delivering small molecules, nucleic acids, peptides, proteins, and cells have led to the development of commercial products and are now guiding the delivery of live-cell therapeutics. Drug delivery technologies have enabled the development of pharmaceutical products that enhance therapeutic delivery, minimize off-target effects, and improve patient compliance. Three drug delivery paradigms have been developed to aid in the successful delivery of small molecules and macromolecules, contributing to the initial clinical success of each therapeutic class.

NATURE BIOMEDICAL ENGINEERING (2021)

Review Immunology

Therapeutic cancer vaccine: building the future from lessons of the past

T. Tran et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

Review Biochemical Research Methods

Overcoming Endosomal Entrapment in Drug Delivery

Dehua Pei et al.

BIOCONJUGATE CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Esterification Delivers a Functional Enzyme into a Human Cell

Valerie T. Ressler et al.

ACS CHEMICAL BIOLOGY (2019)

Article Chemistry, Multidisciplinary

Cytosolic Delivery of Proteins by Bioreversible Esterification

Kalie A. Mix et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Multidisciplinary Sciences

Induction of resident memory T cells enhances the efficacy of cancer vaccine

Mevyn Nizard et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics

Peter Lonn et al.

SCIENTIFIC REPORTS (2016)

Article Cell Biology

Retrograde transport is not required for cytosolic translocation of the B-subunit of Shiga toxin

Maria Daniela Garcia-Castillo et al.

JOURNAL OF CELL SCIENCE (2015)

Article Cell Biology

Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors

Federico Sandoval et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Biochemistry & Molecular Biology

Effects of Tryptophan Content and Backbone Spacing on the Uptake Efficiency of Cell-Penetrating Peptides

Hanna A. Rydberg et al.

BIOCHEMISTRY (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Review Chemistry, Multidisciplinary

Endosomal escape pathways for delivery of biologicals

Amir K. Varkouhi et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Review Microbiology

Shiga toxins - from cell biology to biomedical applications

Ludger Johannes et al.

NATURE REVIEWS MICROBIOLOGY (2010)

Article Biochemical Research Methods

In Vivo Tumor Targeting by the B-Subunit of Shiga Toxin

Thomas Viel et al.

MOLECULAR IMAGING (2008)

Article Biochemistry & Molecular Biology

Shiga toxin B-subunit sequential binding to its natural receptor in lipid membranes

David G. Pina et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)

Article Oncology

In vivo tumor targeting using a novel intestinal pathogen-based delivery approach

Klaus-Peter Janssen et al.

CANCER RESEARCH (2006)

Article Biochemistry & Molecular Biology

Thermodynamic analysis of the structural stability of the Shiga toxin B-subunit

DG Pina et al.

BIOCHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin

X Han et al.

NATURE STRUCTURAL BIOLOGY (2001)