☆ 4.6 Review

Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as a Sensor of Oxidative Stress in Cancer Cells

CELLS (2023)

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Oxidative Stress and Immune Response in Melanoma: Ion Channels as Targets of Therapy

Alessia Remigante et al.

Summary: Oxidative stress and immune response are important factors in the development of cancers, including melanoma. Ion channels, which are aberrantly expressed in tumor cells, play a role in neoplastic transformation, malignant progression, and resistance to therapy. These ion channels, located in cellular membranes, are targets of oxidative stress, which is particularly elevated in melanoma. They also represent promising targets for therapeutic intervention in melanoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection
Article Biochemistry & Molecular Biology

Transient receptor potential channel stimulation induced oxidative stress and apoptosis in the colon of mice with colitis-associated colon cancer: modulator role of Sambucus ebulus L.

Muge Mavioglu Kaya et al.

Summary: The activation of TRPA1, TRPM2, and TRPV1 channels increases apoptotic and oxidant actions in colon cancer cells. Sambucus ebulus L (SEB) treatment inhibits the actions of these channels, thereby reducing colon tumor growth. Hence, TRPA1, TRPM2, and TRPV1 activations could be potential targets for colon tumor treatment.

MOLECULAR BIOLOGY REPORTS (2023)

Add to Collection
Article Multidisciplinary Sciences

Autonomous rhythmic activity in glioma networks drives brain tumour growth

David Hausmann et al.

Summary: This study reveals the impact of network architecture and communication strategies on the biology of glioblastoma, a type of brain tumor. The findings demonstrate the crucial role of periodic Ca2+ activity in the network, and show that targeting this activity can significantly weaken global network communication and reduce tumor cell viability. The study highlights the vulnerability of glioblastoma networks and suggests the potential for developing novel therapies.

NATURE (2023)

Add to Collection
Review Biochemistry & Molecular Biology

The Emerging Role of N-Methyl-D-Aspartate (NMDA) Receptors in the Cardiovascular System: Physiological Implications, Pathological Consequences, and Therapeutic Perspectives

Teresa Soda et al.

Summary: NMDARs are ion channels activated by glutamate that play crucial roles in excitatory neurotransmission and synaptic plasticity. They are not only present in neurons but also in non-neuronal cells and have important functions in the cardiovascular system. Excessive NMDAR activity can lead to cardiac arrhythmias, heart failure, and blood-brain barrier dysfunction.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection
Article Cell Biology

Conjugated polymers mediate intracellular Ca2+ signals in circulating endothelial colony forming cells through the reactive oxygen species-dependent activation of Transient Receptor Potential Vanilloid 1 (TRPV1)

Sharon Negri et al.

Summary: Optical excitation of rr-P3HT was found to activate TRPV1 in ECFCs, leading to an increase in intracellular Ca2+ concentration. This Ca2+ response was triggered by extracellular Ca2+ entry through TRPV1 and subsequent release from the endoplasmic reticulum.

CELL CALCIUM (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

Nicolas Rosa et al.

Summary: The study shows that Bcl-xL and Bcl-2 have similar anti-apoptotic effects in controlling endoplasmic reticulum Ca2+ release, challenging the current understanding of their divergent functions in Ca2+ signaling modulation.

CELL DEATH AND DIFFERENTIATION (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Functional Transient Receptor Potential Ankyrin 1 and Vanilloid 1 Ion Channels Are Overexpressed in Human Oral Squamous Cell Carcinoma

Fruzsina Kiss et al.

Summary: The expression of TRPA1 and TRPV1 is upregulated in oral squamous cell carcinoma (OSCC) and their activation may regulate cancer cell viability.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Review Cell Biology

Molecular mechanisms and consequences of mitochondrial permeability transition

Massimo Bonora et al.

Summary: Mitochondrial permeability transition, mediated by the opening of the mitochondrial permeability transition pore, causes flux of low molecular weight solutes across the inner mitochondrial membrane, triggering various cellular responses. Recent studies have shed light on the molecular nature and mechanisms of the mitochondrial permeability transition pore, paving the way for understanding mitochondrial biology and its pathophysiological consequences.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Add to Collection
Review Physiology

Nobel somatosensations and pain

Peter W. Reeh et al.

Summary: This article reviews the discoveries of the Nobel laureates David Julius and Ardem Patapoutian in the field of temperature and touch receptors, TRPV1 and PIEZO1/2, and discusses topics such as mechanosensitivity and mechanical hyperalgesia.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2022)

Add to Collection
Article Multidisciplinary Sciences

TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence

Valerio Farfariello et al.

Summary: This study reveals the mechanism of how alterations in mitochondrial function and calcium signaling contribute to cellular senescence and tumor growth. The downregulation of TRPC3 protein in senescent fibroblasts leads to increased mitochondrial calcium load and oxidative phosphorylation, promoting cellular senescence. The downregulation of TRPC3 in stromal cells also affects secretome and tumor progression, highlighting its importance in cancer development.

NATURE COMMUNICATIONS (2022)

Add to Collection
Article Engineering, Biomedical

Photothermal Conjugated Polymer Nanoparticles for Suppressing Breast Tumor Growth by Regulating TRPA1 Ion Channels

Boying Li et al.

Summary: TRPA1 ion channels are overexpressed in breast cancer cells and enhance cellular resistance to oxidative stress through upregulating the anti-apoptotic pathway. Near-infrared light-responsive conjugated polymer nanoparticles are designed to regulate TRPA1 ion channels and promote apoptosis of breast cancer cells, reducing drug resistance and suppressing tumor growth.

ADVANCED HEALTHCARE MATERIALS (2022)

Add to Collection
Article Materials Science, Biomaterials

Ion channel-targeting near-infrared photothermal switch with synergistic effect for specific cancer therapy

Shuangling Wang et al.

Summary: A multifunctional nanoplatform integrating chemotherapy, chemodynamic therapy (CDT), and photoactivation of TRPV1 channels has been established for specific cancer therapy. The nanoplatform displays an enhanced anticancer effect both in vitro and in vivo.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Add to Collection
Review Pharmacology & Pharmacy

The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies

Tiecheng Zhong et al.

Summary: This review discusses the association between transient receptor potential (TRP) channels and tumors, as well as their roles in multi-drug resistance, metastasis, apoptosis, proliferation, immune surveillance evasion, and alterations in the tumor microenvironment. Additionally, the expression of relevant TRP channels in various forms of cancer and the efficacy of related inhibitors are discussed.

ACTA PHARMACEUTICA SINICA B (2022)

Add to Collection
Review Biochemistry & Molecular Biology

TRP Channels as Molecular Targets to Relieve Cancer Pain

Milena Duitama et al.

Summary: Transient receptor potential (TRP) channels play a critical role in cancer-related pain. Substances released by the cancer microenvironment modulate the activity of TRP channels, affecting pain transmission. Secondary metabolites derived from plant extracts have the potential to serve as therapeutic agents for relieving cancer-induced pain.

BIOMOLECULES (2022)

Add to Collection
Article Physiology

X-ray irradiation triggers immune response in human T-lymphocytes via store-operated Ca2+ entry and NFAT activation

Dominique Tandl et al.

Summary: This study reveals that X-ray irradiation can activate blood immune cells through inducing oscillations of cytosolic Ca2+ concentration and promoting the expression of transcription factor NFAT, which has implications for the toxicity and therapeutic effects of radiation therapy.

JOURNAL OF GENERAL PHYSIOLOGY (2022)

Add to Collection
Article Pharmacology & Pharmacy

Optical excitation of organic semiconductors as a highly selective strategy to induce vascular regeneration and tissue repair

Francesco Moccia et al.

Summary: Therapeutic neovascularization is a promising strategy to restore vascular network and organ function in cardiovascular disorders. Endothelial colony forming cells are considered the most suitable tool for this. Optical stimulation using photosensitive organic semiconductors can offer a reliable strategy to stimulate neovascularization.

VASCULAR PHARMACOLOGY (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Activated PyK2 and Its Associated Molecules Transduce Cellular Signaling from the Cancerous Milieu for Cancer Metastasis

Dongun Lee et al.

Summary: This review summarizes the role of PyK2 in the cancer microenvironment, including its interaction with acidification and cancer-associated molecules, and highlights its relationship with cancer metastasis and potential as a therapeutic target for cancer cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Transient Receptor Potential (TRP) Channels in Tumor Vascularization

Angelica Perna et al.

Summary: Tumor diseases spread quickly and studies have focused on the role of ion channels, particularly the Transient Receptor Potential (TRP) channels, in tumor vessel formation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Article Biochemistry & Molecular Biology

TRPM8 as an Anti-Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination

Guillaume P. Grolez et al.

Summary: TRPM8 plays a protective role in the progression of prostate cancer and may be a potential therapeutic target. The study demonstrated that TRPM8 overexpression can significantly inhibit tumor growth and metastasis in prostate cancer using a mouse model and in vitro experiments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Article Cell Biology

GABAA and GABAB Receptors Mediate GABA-Induced Intracellular Ca2+ Signals in Human Brain Microvascular Endothelial Cells

Sharon Negri et al.

Summary: This study reveals the molecular mechanisms by which GABA controls endothelial signaling at the neurovascular unit through activating GABA(A) and GABA(B) receptors, and involves multiple signaling pathways, which is of great significance for understanding the function of GABA in the neurovascular unit.

CELLS (2022)

Add to Collection
Review Biochemistry & Molecular Biology

Antioxidant Therapy in Cancer: Rationale and Progress

Maochao Luo et al.

Summary: Cancer is associated with oxidative stress, and targeting this imbalance between reactive oxygen species (ROS) and antioxidants may have therapeutic potential. However, the clinical efficacy of antioxidants in cancer treatment remains uncertain. This review discusses the rationale and recent advances in antioxidant therapy for cancer, as well as potential strategies for improving its effectiveness.

ANTIOXIDANTS (2022)

Add to Collection
Article Multidisciplinary Sciences

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Lavanya Moparthi et al.

Summary: The temperature gating of hTRPA1 is regulated by the N-ARD and VSLD domains. The CTD is involved in cold sensitivity, while the VSLD is involved in heat sensitivity, and they are allosterically coupled to the channel pore gating.

NATURE COMMUNICATIONS (2022)

Add to Collection
Article Cell Biology

Platelet-Derived Extracellular Vesicles Stimulate Migration through Partial Remodelling of the Ca2+ Handling Machinery in MDA-MB-231 Breast Cancer Cells

Mauro Vismara et al.

Summary: PEVs stimulate migration and invasiveness in the highly metastatic MDA-MB-231 breast cancer cell line by inducing a partial remodelling of the Ca2+ handling machinery.

CELLS (2022)

Add to Collection
Article Cell Biology

Activated TRPA1 plays a therapeutic role in TMZ resistance in glioblastoma by altering mitochondrial dynamics

Hao Chen et al.

Summary: This study demonstrates that activating TRPA1 in glioma cells leads to mitochondrial damage and dysfunction, ultimately resulting in apoptosis, which may decrease TMZ resistance in GBM cells.

BMC MOLECULAR AND CELL BIOLOGY (2022)

Add to Collection
Review Oncology

The role of ROS in tumour development and progression

Eric C. Cheung et al.

Summary: Eukaryotic cells have complex systems to regulate reactive oxygen species (ROS), which are deregulated in cancer cells. ROS also modulate the tumor environment and affect stromal cells supporting metabolism, blood supply, and immune responses. The response to ROS is complex and depends on multiple factors, including ROS characteristics and tumor characteristics. Understanding the complexity of ROS in cancers is key to developing ROS-targeting therapies for cancer treatment.

NATURE REVIEWS CANCER (2022)

Add to Collection
Article Cell Biology

[Pt(O,O'-acac)(γ-acac)(DMS)]: Alternative Strategies to Overcome Cisplatin-Induced Side Effects and Resistence in T98G Glioma Cells

Valentina Astesana et al.

Summary: Cisplatin and newly synthesized PtAcacDMS both induce cell death in human glioblastoma cells by increasing intracellular Ca2+ levels, with PtAcacDMS showing stronger cytotoxic effects and a larger increase in Ca2+ levels.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

Add to Collection
Article Cell Biology

NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells

Sharon Negri et al.

Summary: The study revealed that endothelial NMDARs can trigger Ca2+-dependent NO production, and NMDARs may increase Ca2+ concentration in endothelial cells in a flux-independent manner. The signaling of NMDARs may involve mGluRs and lead to Ca2+-dependent NO release.

CELL CALCIUM (2021)

Add to Collection
Article Pharmacology & Pharmacy

TRPA1: Pharmacology, natural activators and role in obesity prevention

Neha Mahajan et al.

Summary: The TRPA1 channel is a calcium permeable, non-selective cation channel expressed in sensory neurons and non-neuronal cells, involved in pain, inflammation, and various physiological functions. It is modulated by pungent compounds in spices and herbs, and its agonism has potential in body weight control, hormone secretion, insulin release, and thermogenesis, making it a possible target for obesity prevention and therapeutic intervention. Recent research has focused on dietary and non-dietary modulation of TRPA1 for its role in combating obesity and related conditions such as insulin resistance in type 2 diabetes.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Add to Collection
Article Neurosciences

A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel

Chang Liu et al.

Summary: A non-covalent agonist, GNE551, has been discovered to activate TRPA1 ion channel differently from covalent agonists, inducing persistent pain. The cryo-EM structure of the TRPA1-GNE551 complex reveals a distinct binding pocket and ligand-interaction mechanism. This biased agonism of TRPA1 has important implications for the development of effective drugs tailored to different disease etiologies.

NEURON (2021)

Add to Collection
Article Multidisciplinary Sciences

Functional expression of the transient receptor potential ankyrin type 1 channel in pancreatic adenocarcinoma cells

Florentina Cojocaru et al.

Summary: This study reveals the endogenous expression of TRPA1 channels in human pancreatic adenocarcinoma cell lines and provides insights into the function of the TRPA1 protein, showing that different cell lines isolated from PDAC patients had varying levels of TRPA1 expression. Activation of TRPA1 by AITC in Panc-1 cells induced non-selective cationic currents, inhibited by the TRPA1 antagonist A-967079, and led to increased intracellular Ca2+ levels. siRNA-induced downregulation of TRPA1 enhanced cell migration, suggesting a role of ion channels independent of pore function, and TRPA1 activation altered cell cycle progression.

SCIENTIFIC REPORTS (2021)

Add to Collection
Review Oncology

Deciphering the Role of Ca2+ Signalling in Cancer Metastasis: From the Bench to the Bedside

Abeer Alharbi et al.

Summary: Ca2+ dyshomeostasis is closely linked to cancer metastasis biology, playing a crucial role in various processes such as cell proliferation, adhesion, motility, invasion, and the epithelial-mesenchymal transition. Calcium signaling pathways have been identified as potential biomarkers and targets for therapeutic intervention in metastatic cancer, which remains a leading cause of cancer-related deaths. The dysregulation of Ca2+ homeostasis is implicated in physiological processes related to tumor progression, and the modulation of specific upstream/downstream targets in Ca2+ signaling may offer a promising approach for treating metastatic cancers.

CANCERS (2021)

Add to Collection
Article Peripheral Vascular Disease

The heterogeneity of cancer endothelium: The relevance of angiogenesis and endothelial progenitor cells in cancer microenvironment

Giovanna Armani et al.

Summary: Tumor-associated vessels formation is crucial for cancer growth and metastasis, involving complex interactions between tumor endothelium, immune response, and other components of the tumor microenvironment. The diversity of cancer endothelium, originating from various sources and exhibiting morphological and molecular aberrations, is recognized. Endothelial Progenitor Cells play an important role in tumor vasculature composition, providing physical support and paracrine signaling for angiogenesis. Various treatment options, particularly novel therapeutic strategies to overcome tumor resistance to anti-angiogenic agents, are being explored.

MICROVASCULAR RESEARCH (2021)

Add to Collection
Article Multidisciplinary Sciences

Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging

Dorian Ziegler et al.

Summary: The lack of ITPR2 in mice leads to improved aging, which is associated with a decreased number of contacts between mitochondria and endoplasmatic reticulum.

NATURE COMMUNICATIONS (2021)

Add to Collection
Article Biology

Brain endothelial cell TRPA1 channels initiate neurovascular coupling

Pratish Thakore et al.

Summary: Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the brain's metabolic demands. TRPA1 channels in capillary endothelial cells act as neural activity sensors, initiating microvascular vasodilatory responses to redirect blood flow to regions of metabolic demand.

ELIFE (2021)

Add to Collection
Article Multidisciplinary Sciences

Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy

Luyan Wu et al.

Summary: The response of tumors to radiotherapy or ferroptosis is closely linked to hydroxyl radical production, and accurate imaging of this reactive oxygen species may allow for monitoring of therapy response. A ratiometric probe has been developed for in vivo imaging of hydroxyl radical generation, providing a reliable method for monitoring treatment response in tumors undergoing erastin-induced ferroptosis or radiotherapy.

NATURE COMMUNICATIONS (2021)

Add to Collection
Review Oncology

Oxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy

Nada S. Aboelella et al.

Summary: It is well-established that cancer cells are constantly under oxidative stress due to increased metabolism from aberrant growth, leading to elevated levels of reactive oxygen species (ROS). There is a prevalent perception that ROS play a crucial role in promoting tumor initiation, progression, metastasis, and drug resistance. Recent advances suggest that cancer immunotherapies can alter tumor redox to intensify oxidative stress, resulting in enhanced antitumor effects.

CANCERS (2021)

Add to Collection
Review Pharmacology & Pharmacy

TRP channels in cancer pain

Amanda Spring de Almeida et al.

Summary: Chronic pain is common during cancer progression, often complicated by bone pain from metastasis, leading to exploration of new mechanisms such as TRP channels for managing cancer-related pain. Studies have shown the potential of TRPV1 and TRPA1 in cancer pain mechanisms, with TRP agonists/antagonists showing promising results in reducing sensitivity in cancer pain models.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Add to Collection
Article Oncology

Combinatorial Effect of PLK1 Inhibition with Temozolomide and Radiation in Glioblastoma

Arvind Pandey et al.

Summary: New strategies are urgently needed to improve the dismal median survivals of only ~15-20 months for glioblastoma (GBM) patients after the current standard of care treatment. This study demonstrates the potential importance of PLK1 inhibitors as an adjunct to GBM therapy, with novel mechanisms of action identified for volasertib.

CANCERS (2021)

Add to Collection
Article Cell Biology

The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma

Francesco De Logu et al.

Summary: Macrophages and reactive oxygen species are believed to be involved in the progression of melanoma, with TRPA1 potentially playing a key role. Increased expression of TRPA1 and 4-HNE in melanoma, along with a TRPA1-dependent response to H2O2, suggest a mechanism where ROS released by M2 macrophages target TRPA1-expressing melanoma cells to affect tumor cell survival and proliferation.

CELLS (2021)

Add to Collection
Article Plant Sciences

Phytochemical Composition, Anti-Inflammatory and ER Stress-Reducing Potential of Sambucus ebulus L. Fruit Extract

Oskan Tasinov et al.

Summary: SE fruits have immunostimulation potential and can reduce ER stress, inhibiting transcription of inflammation related genes and suppressing LPS-stimulated inflammatory markers on transcription and translation levels. The major phytochemicals in SE FAE include hydroxycinnamic acids, proanthocyanidins, and anthocyanins.

PLANTS-BASEL (2021)

Add to Collection
Review Cell Biology

Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function

Michael G. Alvarado et al.

Summary: TRPA1 is a calcium-permeable, non-selective cation channel found in various cell types, including sensory neurons and vascular endothelial cells. It regulates vascular tone through neurogenic and endothelium-dependent mechanisms, playing a crucial role in neurovascular coupling and functional hyperemia in the brain.

CELLS (2021)

Add to Collection
Review Oncology

Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming

Funmilayo O. Adeshakin et al.

Summary: Cancer cells develop mechanisms to resist anoikis, promoting invasion and metastasis. Understanding the mechanisms driving anoikis resistance is crucial for preventing tumor progression and metastasis, with metabolic pathways playing a key role in helping cells evade anoikis.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection
Review Pharmacology & Pharmacy

Redox-sensitive TRP channels: a promising pharmacological target in chemotherapy-induced peripheral neuropathy

Ramandeep Singh et al.

Summary: Chemotherapy-induced peripheral neuropathy (CIPN) and its related pain are major side effects of certain chemotherapeutic agents used in cancer treatment. Redox-sensitive TRP channels may be a promising therapeutic target for alleviating pain, with pharmacological modulators showing efficacy in both preclinical models and clinical studies.

EXPERT OPINION ON THERAPEUTIC TARGETS (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Endothelial signaling at the core of neurovascular coupling: The emerging role of endothelial inward-rectifier K+ (Kir2.1) channels and N-methyl-D-aspartate receptors in the regulation of cerebral blood flow

Sharon Negri et al.

Summary: Neurovascular coupling is the mechanism by which an increase in neuronal activity leads to local vasodilation and an increase in regional cerebral blood flow. Recent evidence suggests that brain microvascular endothelial cells may sense neuronal activity through inward-rectifier K+ channels and NMDA receptors.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?

Sharon Negri et al.

Summary: The intracellular Ca2+ concentration plays a significant role in endothelial cell functions, and both moderate and excessive amounts of ROS can regulate endothelial functions and lead to disorders.ROS-induced endothelial Ca2+ signals are crucial for vascular functions, but aberrant ROS generation can result in endothelial dysfunction and various diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Article Biochemistry & Molecular Biology

TRPM2 Oxidation Activates Two Distinct Potassium Channels in Melanoma Cells through Intracellular Calcium Increase

Loretta Ferrera et al.

Summary: The response to oxidative stimulation in melanoma cells involves the activation of potassium currents and an increase in intracellular calcium levels, mediated by BK, KCa3.1, and TRPM2 channels. Differences in the expression levels of these channels in different cell lines may play a crucial role in melanoma progression. Targeting these ion channels pharmacologically could be a novel strategy to reduce the metastatic potential of melanoma cells alongside traditional treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection
Article Cell Biology

The human amniotic fluid stem cell secretome triggers intracellular Ca2+ oscillations, NF-κB nuclear translocation and tube formation in human endothelial colony-forming cells

Valentina Balducci et al.

Summary: This study elucidated the molecular mechanisms underlying hAFS-CMHypo-induced angiogenesis, including TRPV4-mediated Ca2+ entry, endogenous Ca2+ release, and intracellular Ca2+ oscillations. These findings provide valuable insights for future therapeutic strategies against ischaemic-related myocardial injury.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER

David M. Booth et al.

Summary: The study shows that individual mitochondria generate oxidative bursts at interorganellar contact sites, with Ca2+ channels directly sensing these bursts and responding with transient Ca2+ transients. Under mitochondrial stress or apoptotic stimuli, the frequency and amplitude of the oxidative bursts can be increased.

MOLECULAR CELL (2021)

Add to Collection
Review Physiology

Transient Receptor Potential Ankyrin 1 Channel: An Evolutionarily Tuned Thermosensor

Viktor Sinica et al.

Summary: The TRPA1 channel was discovered nearly two decades ago as a polymodal detector of cold and pain stimuli, with various vertebrate and invertebrate orthologues subsequently identified. Recent developments in cryo-electron microscopy have allowed for a deeper understanding of how thermosensitive channels operate and how they can be targeted with drugs. This has opened up new possibilities for addressing important pharmacological, biophysical, and physiological questions related to TRPA1 and other thermosensitive ion channels.

PHYSIOLOGICAL RESEARCH (2021)

Add to Collection
Review Biochemistry & Molecular Biology

Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy

Aarushi Sharma et al.

Summary: Intracellular Ca2+ distribution is tightly regulated by an array of mechanisms involving Ca2+ chelators, storage proteins, transporters, and organelles. Maintaining cellular Ca2+ homeostasis relies on the collaboration of these components, with cellular organelles acting as Ca2+ reservoirs and contributing significantly to the process. Additionally, inter-organellar Ca2+ signaling plays a crucial role in key cellular processes.

BIOMEDICINES (2021)

Add to Collection
Article Cell Biology

Fundamentals of Cellular Calcium Signaling: A Primer

Martin D. Bootman et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Transient receptor potential (TRP) channels: Biosensors for redox environmental stimuli and cellular status

Reiko Sakaguchi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Add to Collection
Review Physiology

MAMMALIAN TRANSIENT RECEPTOR POTENTIAL TRPA1 CHANNELS: FROM STRUCTURE TO DISEASE

Karel Talavera et al.

PHYSIOLOGICAL REVIEWS (2020)

Add to Collection
Review Biochemistry & Molecular Biology

ROS in cancer therapy: the bright side of the moon

Bruno Perillo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Add to Collection
Article Neurosciences

D-4F, an ApoA-I mimetic peptide ameliorating TRPA1-mediated nocifensive behaviour in a model of neurogenic inflammation

Beatrice Oehler et al.

MOLECULAR PAIN (2020)

Add to Collection
Article Clinical Neurology

Selenium enhances TRPA1 channel-mediated activity of temozolomide in SH-SY5Y neuroblastoma cells

Birol Ozkal et al.

CHILDS NERVOUS SYSTEM (2020)

Add to Collection
Review Cell Biology

Endothelial TRPV1 as an Emerging Molecular Target to Promote Therapeutic Angiogenesis

Sharon Negri et al.

CELLS (2020)

Add to Collection
Review Cardiac & Cardiovascular Systems

Basic and Therapeutic Aspects of Angiogenesis Updated

Guy Eelen et al.

CIRCULATION RESEARCH (2020)

Add to Collection
Review Oncology

Oxidative Stress in Cancer

John D. Hayes et al.

CANCER CELL (2020)

Add to Collection
Article Biochemistry & Molecular Biology

d-Galactose Decreases Anion Exchange Capability through Band 3 Protein in Human Erythrocytes

Alessia Remigante et al.

ANTIOXIDANTS (2020)

Add to Collection
Article Multidisciplinary Sciences

Co-targeting Mitochondrial Ca2+ Homeostasis and Autophagy Enhances Cancer Cells' Chemosensitivity

Charlotte Dubois et al.

ISCIENCE (2020)

Add to Collection
Article Cell Biology

Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel

Lavanya Moparthi et al.

CELL CALCIUM (2020)

Add to Collection
Review Biochemistry & Molecular Biology

Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer

Simone Patergnani et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection
Article Medicine, Research & Experimental

Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line

Haci Ahmet Deveci et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Add to Collection
Article Biochemistry & Molecular Biology

Susceptibility of erythrocytes from different sources to xenobiotics-induced lysis

Rosalia Crupi et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY (2019)

Add to Collection
Article Biochemistry & Molecular Biology

Honey-Mediated Wound Healing: H2O2 Entry through AQP3 Determines Extracellular Ca2+ Influx

Simona Martinotti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection
Article Cell Biology

Imaging elemental events of store-operated Ca2+ entry in invading cancer cells with plasmalemmal targeted sensors

Fujian Lu et al.

JOURNAL OF CELL SCIENCE (2019)

Add to Collection
Review Cell Biology

Redox regulation of ER and mitochondrial Ca2+ signaling in cell survival and death

Suresh K. Joseph et al.

CELL CALCIUM (2019)

Add to Collection
Article Oncology

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca2+ Release through the Two-Pore Channel TPC1 in Metastatic Colorectal Cancer Cells

Pawan Faris et al.

CANCERS (2019)

Add to Collection
Article Oncology

Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis

Michela Bernardini et al.

CANCERS (2019)

Add to Collection
Article Oncology

Purinergic Calcium Signals in Tumor-Derived Endothelium

Giorgia Scarpellino et al.

CANCERS (2019)

Add to Collection
Article Biochemistry & Molecular Biology

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain

John V. Lin King et al.

CELL (2019)

Add to Collection
Article Multidisciplinary Sciences

Conjugated polymers optically regulate the fate of endothelial colony-forming cells

F. Lodola et al.

SCIENCE ADVANCES (2019)

Add to Collection
Article Cell Biology

Photosensitizer Activation Drives Apoptosis by Interorganellar Ca2+ Transfer and Superoxide Production in Bystander Cancer Cells

Chiara Nardin et al.

CELLS (2019)

Add to Collection
Article Cell Biology

Glutamate triggers intracellular Ca2+ oscillations and nitric oxide release by inducing NAADP- and InsP3-dependent Ca2+ release in mouse brain endothelial cells

Estella Zuccolo et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Add to Collection
Review Neurosciences

TRPA1: a molecular view

Jannis E. Meents et al.

JOURNAL OF NEUROPHYSIOLOGY (2019)

Add to Collection
Review Oncology

Endolysosomal Ca2+ Signalling and Cancer Hallmarks: Two-Pore Channels on the Move, TRPML1 Lags Behind!

Pawan Faris et al.

CANCERS (2019)

Add to Collection
Review Cell Biology

TRPC3-mediated Ca2+ signals as a promising strategy to boost therapeutic angiogenesis in failing hearts: The role of autologous endothelial colony forming cells

Francesco Moccia et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Add to Collection
Article Oncology

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

Nobuaki Takahashi et al.

CANCER CELL (2018)

Add to Collection
Editorial Material Oncology

ROS Promotes Cancer Cell Survival through Calcium Signaling

Colleen R. Reczek et al.

CANCER CELL (2018)

Add to Collection
Review Cell Biology

TRPs and Ca2+ in cell death and survival

Ingrid Fliniaux et al.

CELL CALCIUM (2018)

Add to Collection
Review Physiology

ION CHANNELS IN CANCER: ARE CANCER HALLMARKS ONCOCHANNELOPATHIES?

Natalia Prevarskaya et al.

PHYSIOLOGICAL REVIEWS (2018)

Add to Collection
Review Cell Biology

Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes

Martijn Kerkhofs et al.

CELL DEATH & DISEASE (2018)

Add to Collection
Review Oncology

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings

Giampaolo Morciano et al.

NEOPLASIA (2018)

Add to Collection
Article Cell Biology

TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1

Tullio Genova et al.

JOURNAL OF CELL BIOLOGY (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF)

Eric Vancauwenberghe et al.

MOLECULAR CARCINOGENESIS (2017)

Add to Collection
Review Multidisciplinary Sciences

TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O2 sensing

Yasuo Mori et al.

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2017)

Add to Collection
Article Multidisciplinary Sciences

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

Jonathan Berrout et al.

NATURE COMMUNICATIONS (2017)

Add to Collection
Article Oncology

VEGF-induced intracellular Ca2+ oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells

Francesco Lodola et al.

ONCOTARGET (2017)

Add to Collection
Article Multidisciplinary Sciences

Calmodulin is responsible for Ca2+-dependent regulation of TRPA1 Channels

Raquibul Hasan et al.

SCIENTIFIC REPORTS (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Membrane translocation of transient receptor potential ankyrin 1 induced by inflammatory cytokines in lung cancer cells

Kenji Takahashi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Add to Collection
Review Oncology

The calcium-cancer signalling nexus

Gregory R. Monteith et al.

NATURE REVIEWS CANCER (2017)

Add to Collection
Article Oncology

Activation of TRPA1 Channel by Antibacterial Agent Triclosan Induces VEGF Secretion in Human Prostate Cancer Stromal Cells

Sandra Derouiche et al.

CANCER PREVENTION RESEARCH (2017)

Add to Collection
Review Oncology

Temozolomide in the Era of Precision Medicine

Anish Thomas et al.

CANCER RESEARCH (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Functional and Structural Divergence in Human TRPV1 Channel Subunits by Oxidative Cysteine Modification

Nozomi Ogawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Add to Collection
Review Biochemistry & Molecular Biology

Activation of apoptosis signalling pathways by reactive oxygen species

Maureen Redza-Dutordoir et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Add to Collection
Review Biochemistry & Molecular Biology

Targeting Stim and Orai Proteins as an Alternative Approach in Anticancer Therapy

Francesco Moccia et al.

CURRENT MEDICINAL CHEMISTRY (2016)

Add to Collection
Article Pharmacology & Pharmacy

Significance of TRP channels in oxidative stress

Shinichiro Yamamoto et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

Add to Collection
Review Biochemistry & Molecular Biology

Prolyl hydroxylase domain enzymes and their role in cell signaling and cancer metabolism

Tra Ly Nguyen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)

Add to Collection
Article Cell Biology

Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons

Shujiang Shang et al.

JOURNAL OF CELL BIOLOGY (2016)

Add to Collection
Article Physiology

The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1

Parmvir K. Bahia et al.

JOURNAL OF GENERAL PHYSIOLOGY (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface

David M. Booth et al.

MOLECULAR CELL (2016)

Add to Collection
Review Cell Biology

ROS homeostasis and metabolism: a dangerous liason in cancer cells

E. Panieri et al.

CELL DEATH & DISEASE (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy

Claire M. Doskey et al.

REDOX BIOLOGY (2016)

Add to Collection
Article Multidisciplinary Sciences

Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity

Lavanya Moparthi et al.

SCIENTIFIC REPORTS (2016)

Add to Collection
Article Biochemistry & Molecular Biology

May the remodeling of the Ca2+ toolkit in endothelial progenitor cells derived from cancer patients suggest alternative targets for anti-angiogenic treatment?

Francesco Moccia et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

Add to Collection
Article Biochemistry & Molecular Biology

Streptozotocin Stimulates the Ion Channel TRPA1 Directly INVOLVEMENT OF PEROXYNITRITE

David A. Andersson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Add to Collection
Article Chemistry, Multidisciplinary

A Potent and Site-Selective Agonist of TRPA1

Junichiro Takaya et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Add to Collection
Article Multidisciplinary Sciences

Structure of the TRPA1 ion channel suggests regulatory mechanisms

Candice E. Paulsen et al.

NATURE (2015)

Add to Collection
Article Neurosciences

Physical basis of apparent pore dilation of ATP-activated P2X receptor channels

Mufeng Li et al.

NATURE NEUROSCIENCE (2015)

Add to Collection
Article Biochemistry & Molecular Biology

Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation

Michelle N. Sullivan et al.

SCIENCE SIGNALING (2015)

Add to Collection
Article Biochemistry & Molecular Biology

Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation

Michelle N. Sullivan et al.

SCIENCE SIGNALING (2015)

Add to Collection
Article Physiology

Propofol-induced pain sensation involves multiple mechanisms in sensory neurons

Rei Nishimoto et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2015)

Add to Collection
Article Chemistry, Medicinal

Development of novel azabenzofuran TRPA1 antagonists as in vivo tools

Katrina W. Copeland et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Add to Collection
Article Cell Biology

Calcium regulation by temperature-sensitive transient receptor potential channels in human uveal melanoma cells

Stefan Mergler et al.

CELLULAR SIGNALLING (2014)

Add to Collection
Article Biochemistry & Molecular Biology

Isoform-and Species-specific Control of Inositol 1,4,5-Trisphosphate (IP3) Receptors by Reactive Oxygen Species

Szava Bansaghi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Add to Collection
Article Chemistry, Medicinal

Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists

Lisa Rooney et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Add to Collection
Article Multidisciplinary Sciences

Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

Lavanya Moparthi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Add to Collection
Review Oncology

Mitochondrial reactive oxygen species and cancer

Lucas B. Sullivan et al.

CANCER & METABOLISM (2014)

Add to Collection
Article Pharmacology & Pharmacy

Stimulation of the chemosensory TRPA1 cation channel by volatile toxic substances promotes cell survival of small cell lung cancer cells

Eva A. M. Schaefer et al.

BIOCHEMICAL PHARMACOLOGY (2013)

Add to Collection
Review Cell Biology

Hydrogen sulfide as a regulator of calcium channels

Luca Munaron et al.

CELL CALCIUM (2013)

Add to Collection
Article Biochemistry & Molecular Biology

Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain

Vasilina Zayats et al.

JOURNAL OF MOLECULAR MODELING (2013)

Add to Collection
Review Biotechnology & Applied Microbiology

Modulation of oxidative stress as an anticancer strategy

Chiara Gorrini et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Add to Collection
Review Biotechnology & Applied Microbiology

Glutathione levels in human tumors

Michael P. Gamcsik et al.

BIOMARKERS (2012)

Add to Collection
Article Biochemistry & Molecular Biology

C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel

Lucie Sura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Add to Collection
Article Multidisciplinary Sciences

TRPA1 Has a Key Role in the Somatic Pro-Nociceptive Actions of Hydrogen Sulfide

David A. Andersson et al.

PLOS ONE (2012)

Add to Collection
Article Pharmacology & Pharmacy

Species Comparison and Pharmacological Characterization of Human, Monkey, Rat, and Mouse TRPA1 Channels

Bruce R. Bianchi et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

Add to Collection
Article Biochemistry & Molecular Biology

The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1

Abdul Samad et al.

BIOCHEMICAL JOURNAL (2011)

Add to Collection
Article Cell Biology

Cyclic ADP ribose is a novel regulator of intracellular Ca2+oscillations in human bone marrow mesenchymal stem cells

Rong Tao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2011)

Add to Collection
Article Neurosciences

Activation of TRPA1 by membrane permeable local anesthetics

Andreas Leffler et al.

MOLECULAR PAIN (2011)

Add to Collection
Article Biochemistry & Molecular Biology

TRPA1 underlies a sensing mechanism for O2

Nobuaki Takahashi et al.

NATURE CHEMICAL BIOLOGY (2011)

Add to Collection
Article Multidisciplinary Sciences

Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

Yih-Fung Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Add to Collection
Article Cell Biology

Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation

T. G. Banke et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)

Add to Collection
Article Chemistry, Medicinal

Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor

Jeff DeFalco et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Add to Collection
Article Biophysics

Agonist-Induced Changes in Ca2+ Permeation through the Nociceptor Cation Channel TRPA1

Yuji Karashima et al.

BIOPHYSICAL JOURNAL (2010)

Add to Collection
Article Neurosciences

TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats

Steve McGaraughty et al.

MOLECULAR PAIN (2010)

Add to Collection
Article Neurosciences

Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat

Hong Wei et al.

NEUROPHARMACOLOGY (2010)

Add to Collection
Article Physiology

Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs

Hongzhen Hu et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2010)

Add to Collection
Article Cell Biology

The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling

Maarten Gees et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Add to Collection
Article Biochemistry & Molecular Biology

Diallyl sulfides in garlic activate both TRPA1 and TRPV1

Kanako Koizumi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Add to Collection
Article Cell Biology

Differentiation Dependent Expression of TRPA1 and TRPM8 Channels in IMR-32 Human Neuroblastoma Cells

Lauri M. Louhivuori et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2009)

Add to Collection
Article Neurosciences

Pore dilation occurs in TRPA1 but not in TRPM8 channels

Jun Chen et al.

MOLECULAR PAIN (2009)

Add to Collection
Article Pharmacology & Pharmacy

Nitrooleic Acid, an Endogenous Product of Nitrative Stress, Activates Nociceptive Sensory Nerves via the Direct Activation of TRPA1

Thomas E. Taylor-Clark et al.

MOLECULAR PHARMACOLOGY (2009)

Add to Collection
Article Multidisciplinary Sciences

TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice

Takashi Miyamoto et al.

PLOS ONE (2009)

Add to Collection
Article Pharmacology & Pharmacy

Thymol and related alkyl phenols activate the hTRPA1 channel

S. P. Lee et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Add to Collection
Article Biochemistry & Molecular Biology

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

Yuanyuan Y. Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Add to Collection
Article Medicine, Research & Experimental

TRPA1 is a major oxidant sensor in murine airway sensory neurons

Bret F. Bessac et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Add to Collection
Article Neurosciences

Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress

David A. Andersson et al.

JOURNAL OF NEUROSCIENCE (2008)

Add to Collection
Article Neurosciences

Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal

T. E. Taylor-Clark et al.

JOURNAL OF PHYSIOLOGY-LONDON (2008)

Add to Collection
Review Physiology

Breathtaking TRP Channels: TRPA1 and TRPV1 in Airway Chemosensation and Reflex Control

Bret F. Bessac et al.

PHYSIOLOGY (2008)

Add to Collection
Article Multidisciplinary Sciences

TRPA1 mediates formalin-induced pain

Colleen R. McNamara et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Add to Collection
Article Biochemistry & Molecular Biology

Transient receptor potential channel a1 is directly gated by calcium ions

Julia F. Doerner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Add to Collection
Article Multidisciplinary Sciences

TRP channel activation by reversible covalent modification

Andrew Hinman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Add to Collection
Article Biochemistry & Molecular Biology

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

DM Bautista et al.

CELL (2006)

Add to Collection
Article Multidisciplinary Sciences

Pungent products from garlic activate the sensory ion channel TRPA1

DM Bautista et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Add to Collection
Article Multidisciplinary Sciences

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

SE Jordt et al.

NATURE (2004)

Add to Collection
Article Oncology

Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells

KA Ahmad et al.

CANCER RESEARCH (2004)

Add to Collection
Article Biochemistry & Molecular Biology

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia -: A mechanism of O2 sensing

NS Chandel et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.