☆ 4.6 Article

Smoking Suppresses the Therapeutic Potential of Adipose Stem Cells in Crohn's Disease Patients through Epigenetic Changes

CELLS (2023)

Related references

Note: Only part of the references are listed.

Review Gastroenterology & Hepatology

The Complex Relationship Between Microbiota, Immune Response and Creeping Fat in Crohn's Disease

Roger Suau et al.

Summary: In recent years, there has been a growing interest in the pathological involvement of creeping fat in Crohn's disease (CD). Despite its protective nature, the abnormal inflammatory activity of creeping fat may worsen the severity of CD, and the inflammatory process associated with CD involves various cellular and molecular changes.

JOURNAL OF CROHNS & COLITIS (2022)

Add to Collection

Review Endocrinology & Metabolism

Congenital Adrenal Hyperplasia and Ehlers-Danlos Syndrome

Roxana Marino et al.

Summary: This article discusses the relationship between congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency and TNXB gene defects associated with Ehlers Danlos syndrome (EDS). The article introduces the strategies for analyzing the TNXB gene, genetic variations and status in different populations, and discusses the clinical features of EDS and long-term follow-up recommendations.

FRONTIERS IN ENDOCRINOLOGY (2022)

Add to Collection

Article Cell Biology

Effects of Adipose-Derived Stem Cells and Their Conditioned Medium in a Human Ex Vivo Wound Model

Xiao Guo et al.

Summary: This study used ex vivo human skin cultured as a model for superficial wounds to investigate the effects of adipose-derived stem cells (ASCs) on wound healing. The results showed that ASCs promoted re-epithelialization and vascularization, and modulated the inflammatory immune response. The expression of inflammatory mediators and growth factors varied depending on the treatment, indicating that the wound microenvironment can influence the secreted mediators and the mode of action of ASCs in wound healing.

CELLS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Impact of the Exposome on the Epigenome in Inflammatory Bowel Disease Patients and Animal Models

Sophie Vieujean et al.

Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, influenced by both genetic predisposition and environmental factors. Epigenetics, including DNA methylation, histone modifications, and non-coding RNAs, can explain how the exposome affects gene expression to contribute to intestinal inflammation. This study identified various environmental factors, such as maternal lifestyle, breastfeeding, microbiota, diet, smoking habits, vitamin D, and drugs, that epigenetically influence the occurrence of IBD. However, the role of exposome-induced epigenetic modifications in IBD is still understudied.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Cell & Tissue Engineering

The Role of Epigenetic in Dental and Oral Regenerative Medicine by Different Types of Dental Stem Cells: A Comprehensive Overview

Ahmed Hussain et al.

Summary: Postnatal teeth, wisdom teeth, and exfoliated deciduous teeth can be used for dental stem cell (DSC) research. These stem cells, with their differentiation potential, are considered promising candidates for dental and oral regeneration. The role of epigenetic regulation in maintaining the multipotency of DSCs is discussed in this review.

STEM CELLS INTERNATIONAL (2022)

Add to Collection

Article Cell Biology

Athletes' Mesenchymal Stem Cells Could Be the Best Choice for Cell Therapy in Omicron-Infected Patients

Mona Saheli et al.

Summary: The Omicron variant of SARS-CoV-2, which has 32 mutations, has resulted in a high incidence of breakthrough infections or re-infections and reduced vaccine protection. Stem cell-based therapy is suggested as an effective treatment option due to the ability of stem cells to support respiratory epithelial cells, restore alveolar bioenergetics, and increase immunomodulatory cytokine secretion. However, the survival and growth of transplanted stem cells are hindered by an inappropriate microenvironment, ischemia, inflammation, and oxidative stress. Exercise-training can improve the survival and growth of transplanted cells by upregulating defense mechanisms and growth signaling. Using athletes' stem cells may enhance the outcomes of stem cell therapy in Omicron-affected patients.

CELLS (2022)

Add to Collection

Article Immunology

ETS-1 facilitates Th1 cell-mediated mucosal inflammation in inflammatory bowel diseases through upregulating CIRBP

Qiong He et al.

Summary: The study reveals that ETS-1 is highly expressed in IBD patients and promotes Th1-driven mucosal inflammation through CIRBP. CIRBP may serve as a novel therapeutic target for the treatment of human IBD.

JOURNAL OF AUTOIMMUNITY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming

Mohsen Afarideh et al.

Summary: Obesity induces global genomic epigenetic alterations in swine MSCs, primarily involving reduced levels of DNA hydroxymethylation and histone tri-methylation, which are associated with MSC function and clinical features of obesity. Co-incubation with vitamin C enhances some epigenetic marks in obese MSCs, suggesting potential therapeutic targets for obesity.

EPIGENETICS (2021)

Add to Collection

Review Cell Biology

DNA methylation and regulation of gene expression: Guardian of our health

Gaurab Aditya Dhar et al.

Summary: DNA methylation serves as a critical epigenetic mark in higher eukaryotes, regulating gene expression. The methylation pattern in the genome undergoes changes during developmental stages, influenced by interactions between the epigenome, genome, and environmental factors.

NUCLEUS-INDIA (2021)

Add to Collection

Article Oncology

Age affects the paracrine activity and differentiation potential of human adipose-derived stem cells

Jeong Seop Park et al.

Summary: The study investigated the impact of age on adipose tissue-derived stem cell (ADSC) activity, revealing that increased age led to decreased cell activity, altered paracrine action, and reduced differentiation potential.Age should be considered prior to ADSC transplantation.

MOLECULAR MEDICINE REPORTS (2021)

Add to Collection

Article Cell Biology

Human Adipose Tissue-Derived Mesenchymal Stromal Cells Inhibit CD4+T Cell Proliferation and Induce Regulatory T Cells as Well as CD127 Expression on CD4+CD25+T Cells

Agnese Fiori et al.

Summary: Mesenchymal stromal cells (MSC) have immunomodulatory effects on various immune cells. In this study, human adipose tissue-derived MSC (ASC) were found to inhibit CD4 + T cell proliferation, induce Treg cells, and modulate cytokine secretion, suggesting a potential role in immune regulation. These findings highlight the complex interplay between ASC and CD4 + T cells.

CELLS (2021)

Add to Collection

Review Cell Biology

Comparison of the effect of cigarette smoke on mesenchymal stem cells and dental stem cells

Brandon Nguyen et al.

Summary: The persistent prevalence of cigarette smoking continues to contribute to preventable disease and death in the United States. There is still much to learn about the impact of cigarette smoke and nicotine on stem cells, particularly in the field of regenerative medicine. Recent studies have focused on the effects of cigarette smoke and nicotine on mesenchymal stem cells, with a specific emphasis on dental stem cells.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)

Add to Collection

Review Substance Abuse

Smoking and risk of negative outcomes among COVID-19 patients: A systematic review and meta-analysis

Adinat Umnuaypornlert et al.

Summary: This study found that smoking, whether current or former, significantly increases the risk of COVID-19 severity and death among patients. Further research into the causative link and underlying mechanisms of this association is necessary.

TOBACCO INDUCED DISEASES (2021)

Add to Collection

Review Cell & Tissue Engineering

Stem cell therapy for Crohn's disease: systematic review and meta-analysis of preclinical and clinical studies

Ruo Wang et al.

Summary: Stem cell transplantation is a valuable supplementary therapy for Crohn's disease, as it can reduce disease activity and improve symptoms in patients.

STEM CELL RESEARCH & THERAPY (2021)

Add to Collection

Review Physiology

Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential

Sara Al-Ghadban et al.

PHYSIOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Adipose stem cells in obesity: challenges and opportunities

Sunhye Shin et al.

BIOSCIENCE REPORTS (2020)

Add to Collection

Article Oncology

Adipose stem cells from patients with Crohn's disease show a distinctive DNA methylation pattern

Carolina Serena et al.

CLINICAL EPIGENETICS (2020)

Add to Collection

Article Microbiology

Mystery Solved: Why Smoke Extract Worsens Disease in Smokers with Crohn's Disease and Not Ulcerative Colitis? Gut MAP!

Dania AlQasrawi et al.

MICROORGANISMS (2020)

Add to Collection

Article Cell Biology

Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice

Nicola Alessio et al.

AGING-US (2020)

Add to Collection

Article Genetics & Heredity

Classical-like Ehlers-Danlos syndrome: a clinical description of 20 newly identified individuals with evidence of tissue fragility

Claire Green et al.

GENETICS IN MEDICINE (2020)

Add to Collection

Review Substance Abuse

Smoking increases the risk of infectious diseases: A narrative review

Chen Jiang et al.

TOBACCO INDUCED DISEASES (2020)

Add to Collection

Review Gastroenterology & Hepatology

Defining Failure of Medical Therapy for Inflammatory Bowel Disease

Neil Volk et al.

INFLAMMATORY BOWEL DISEASES (2019)

Add to Collection

Article Genetics & Heredity

Molecular dissection of the oncogenic role of ETS1 in the mesenchymal subtypes of head and neck squamous cell carcinoma

Christian Gluck et al.

PLOS GENETICS (2019)

Add to Collection

Article Cell & Tissue Engineering

Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes

June Seok Heo et al.

STEM CELLS INTERNATIONAL (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

RnBeads 2.0: comprehensive analysis of DNA methylation data

Fabian Mueller et al.

GENOME BIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

A DNA methylation biomarker of alcohol consumption

C. Liu et al.

MOLECULAR PSYCHIATRY (2018)

Add to Collection

Article Gastroenterology & Hepatology

Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease

Julian Panes et al.

GASTROENTEROLOGY (2018)

Add to Collection

Article Cell & Tissue Engineering

Cigarette Smoking Impairs Adipose Stromal Cell Vasculogenic Activity and Abrogates Potency to Ameliorate Ischemia

Daria Barwinska et al.

STEM CELLS (2018)

Add to Collection

Review Cell & Tissue Engineering

Transforming growth factor-β in stem cells and tissue homeostasis

Xin Xu et al.

BONE RESEARCH (2018)

Add to Collection

Article Oncology

Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study

Timothy M. Barrow et al.

JOURNAL OF PATHOLOGY (2017)

Add to Collection

Review Cell & Tissue Engineering

Concise Review: The Deleterious Effects of Cigarette Smoking and Nicotine Usage and Mesenchymal Stem Cell Function and Implications for Cell-Based Therapies

Jordan M. Greenberg et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

Add to Collection

Article Cell & Tissue Engineering

Crohn's Disease Disturbs the Immune Properties of Human Adipose-Derived Stem Cells Related to Inflammasome Activation

Carolina Serena et al.

STEM CELL REPORTS (2017)

Add to Collection

Article Cell & Tissue Engineering

Obesity Determines the Immunophenotypic Profile and Functional Characteristics of Human Mesenchymal Stem Cells From Adipose Tissue

Gisela Pachon-Pena et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

Add to Collection

Article Multidisciplinary Sciences

Acute stimulation of mesenchymal stem cells with cigarette smoke extract affects their migration, differentiation, and paracrine potential

Elizabeth A. Wahl et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Article Biochemical Research Methods

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

Martin J. Aryee et al.

BIOINFORMATICS (2014)

Add to Collection

Article Biochemical Research Methods

Comprehensive analysis of DNA methylation data with RnBeads

Yassen Assenov et al.

NATURE METHODS (2014)

Add to Collection

Article Biochemical Research Methods

A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

Andrew E. Teschendorff et al.

BIOINFORMATICS (2013)

Add to Collection

Review Biochemistry & Molecular Biology

Review of Ets1 structure, function, and roles in immunity

Lee Ann Garrett-Sinha

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Add to Collection

Article Public, Environmental & Occupational Health

Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies

Andrew E. Jaffe et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2012)

Add to Collection

Article Gastroenterology & Hepatology

The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management

A. Dignass et al.

JOURNAL OF CROHNS & COLITIS (2010)

Add to Collection

Article Biochemistry & Molecular Biology

Identification and characterization of multiple species of tenascin-X in human serum

D. F. Egging et al.

FEBS JOURNAL (2007)

Add to Collection

Review Surgery

Smoking and disease recurrence after operation for Crohn's disease

T Yamamoto et al.

BRITISH JOURNAL OF SURGERY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.