Ferroptosis Regulated by Hypoxia in Cells

Ferroptosis is an oxidative damage-related, iron-dependent regulated cell death with intracellular lipid peroxide accumulation, which is associated with many physiological and pathological processes. It exhibits unique features that are morphologically, biochemically, and immunologically distinct from other regulated cell death forms. Ferroptosis is regulated by iron metabolism, lipid metabolism, anti-oxidant defense systems, as well as various signal pathways. Hypoxia, which is found in a group of physiological and pathological conditions, can affect multiple cellular functions by activation of the hypoxia-inducible factor (HIF) signaling and other mechanisms. Emerging evidence demonstrated that hypoxia regulates ferroptosis in certain cell types and conditions. In this review, we summarize the basic mechanisms and regulations of ferroptosis and hypoxia, as well as the regulation of ferroptosis by hypoxia in physiological and pathological conditions, which may contribute to the numerous diseases therapies.

Automated summary

Ferroptosis is a type of regulated cell death that is dependent on iron and involves the accumulation of intracellular lipid peroxides. It exhibits distinct features from other forms of regulated cell death in terms of morphology, biochemistry, and immunology. Ferroptosis is regulated by iron metabolism, lipid metabolism, antioxidant defense systems, and various signaling pathways. Hypoxia, which occurs in both physiological and pathological conditions, has been found to regulate ferroptosis in certain cell types and conditions through the activation of hypoxia-inducible factor (HIF) signaling and other mechanisms. This review provides an overview of the basic mechanisms and regulations of ferroptosis and hypoxia, as well as the regulation of ferroptosis by hypoxia in different physiological and pathological conditions, which may have implications for the treatment of various diseases.