☆ 4.6 Review

The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas

CANCERS (2023)

Related references

Note: Only part of the references are listed.

Article Dermatology

Targeted deep sequencing reveals genomic alterations of actinic keratosis/cutaneous squamous cell carcinoma in situ and cutaneous squamous cell carcinoma

Yoon-Seob Kim et al.

Summary: This study investigates the genomic alterations between actinic keratosis (AK) and cutaneous squamous cell carcinoma (cSCC), and identifies TP53 and NOTCH1 as common driver mutations in cSCC. The study also reveals that cSCC has a higher abundance of somatic mutations and copy number alterations (CNAs) compared to AK/CIS, and that ultraviolet is the main cause of these mutations in both AK/CIS and cSCC.

EXPERIMENTAL DERMATOLOGY (2023)

Add to Collection

Review Biochemistry & Molecular Biology

The role of truncated p53 isoforms in the DNA damage response

Luiza Steffens Reinhardt et al.

Summary: The tumor suppressor protein p53 is activated in response to DNA damage and regulates the expression of genes involved in the DNA damage response. Different isoforms of p53 have been found to alter gene transcription or protein interactions, revealing an alternative DNA damage response. This review focuses on the role of p53 isoforms in the response to DNA damage. DNA damage-induced alternative splicing may modulate the expression of C-terminally truncated isoforms, while alternative translation plays a role in modulating the expression of N-terminally truncated isoforms. The DNA damage response induced by p53 isoforms may enhance the canonical p53 response or block cell death mechanisms, potentially contributing to chemoresistance in cancer. A better understanding of the involvement of p53 isoforms in cell fate decisions could reveal potential therapeutic targets in cancer and other diseases.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2023)

Add to Collection

Article Multidisciplinary Sciences

Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage

Annarita Nappi et al.

Summary: In this study, the authors investigate the role of thyroid hormones in tumor progression and identify the thyroid hormone activating enzyme D2 as a p53 target gene. They find that p53, as a cell stress sensor and tumor suppressor, suppresses D2 expression, leading to decreased availability of intracellular thyroid hormones. Conversely, loss of p53 enhances D2/TH signaling, promoting the fitness of tumor cells through modulation of genes involved in DNA damage and repair and redox signaling. In vivo deletion of D2 significantly reduces cancer progression, suggesting that targeting thyroid hormones could be a general approach to reduce invasiveness in p53-mutated neoplasms.

NATURE COMMUNICATIONS (2023)

Add to Collection

Article Oncology

Elucidating the Genetic Landscape of Oral Leukoplakia to Predict Malignant Transformation

Leon J. Wils et al.

Summary: Oral leukoplakia is a common potentially malignant oral disorder, with a 1% to 5% annual malignant transformation rate. Although no definitive risk stratification model exists, next-generation sequencing can be used to predict the risk for malignant transformation. Based on genetic alterations and dysplasia, we developed a prediction model for malignant transformation in oral leukoplakia.

CLINICAL CANCER RESEARCH (2023)

Add to Collection

Review Oncology

Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment

Ayana T. Ruffin et al.

Summary: Targeted immunotherapy has improved survival in head and neck squamous cell carcinoma (HNSCC), but new immunotherapies considering the entire HNSCC tumour microenvironment are needed to enhance T cell responses. Recent advancements have provided a comprehensive understanding of the cellular constituents and interactions within the complex HNSCC microenvironment.

NATURE REVIEWS CANCER (2023)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma

Libo Liang et al.

Summary: This study aimed to understand the molecular mechanisms of tongue squamous cell carcinoma better by combining whole-genome sequencing, whole-genome methylation, and whole-transcriptome analyses. Through multi-omics sequencing, we identified differentially methylated intervals, methylated loop sites, methylated promoters, and transcripts associated with tongue squamous cell carcinoma. We found mutated methylation promoters significantly associated with mRNA and lncRNA expression levels, which are involved in triggering the mitogen-activated protein kinase cascade and affecting the prognosis of tongue squamous cell carcinoma patients.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2023)

Add to Collection

Review Multidisciplinary Sciences

Tertiary lymphoid structures in cancer

Ton N. Schumacher et al.

Summary: This article discusses the current knowledge on TLSs in cancer, focusing on the drivers of TLS formation, the function and contribution of TLSs to the antitumor immune response, and the potential of TLSs as therapeutic targets in human cancers.

SCIENCE (2022)

Add to Collection

Article Obstetrics & Gynecology

Overexpression of TGF-β1 and SDF-1 in cervical cancer-associated fibroblasts promotes cell growth, invasion and migration

Ling Xiao et al.

Summary: The overexpression of TGF-beta 1 and SDF-1 in cervical cancer-associated fibroblasts (CAFs) promotes cell growth, invasion, and migration. This study found increased expression of Vimentin and α-SMA in CAFs, as well as notably increased levels of TGF-beta 1 and SDF-1. Co-culturing CAFs with Hela cells enhanced proliferation, migration, invasion, colony formation, and cell cycle progression, while reducing apoptosis, effects that were reversed by neutralizing antibodies to TGF-beta 1 and SDF-1.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2022)

Add to Collection

Review Cell Biology

Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons

Adel Naimi et al.

Summary: The discovery of immune checkpoint proteins led to the development of immune checkpoint inhibitors (ICIs), a promising approach in tumor immunotherapy. However, resistance and treatment-related toxicities remain challenges in the clinical application of ICIs.

CELL COMMUNICATION AND SIGNALING (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma

Matthew L. Hedberg et al.

Summary: Non-melanoma skin cancers, primarily basal cell carcinomas and squamous cell carcinomas, are the most common form of cancer in the US. The increasing incidence of squamous cell carcinomas leads to significant morbidity and rising treatment costs, exceeding one billion dollars annually. Research on the molecular basis and development of squamous cell carcinomas aims to provide new insights into pathogenesis and drive the development of cost-effective and low morbidity therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Immunotherapy for the Treatment of Squamous Cell Carcinoma: Potential Benefits and Challenges

Tuba M. Ansary et al.

Summary: Melanoma and squamous cell carcinoma (SCC) are the most common neoplasms in white people, with increasing incidence rates. SCC, the most prevalent malignancy among nonmelanoma skin cancers, is influenced by factors such as extreme ultraviolet radiation, hereditary predisposition, and immunosuppression. SCC tumors have a high tumor mutational burden and expression of immune checkpoints, making them highly responsive to immunotherapies. However, challenges such as resistance to immunotherapy and difficulty in patient selection exist. This review explores the genetic alterations related to SCC, factors contributing to the benefits of immunotherapy, and challenges associated with this treatment regime.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Dermatology

Features and clinical significance of tertiary lymphoid structure in cutaneous squamous cell carcinoma

Y. H. Wu et al.

Summary: This study investigated the features of tertiary lymphoid structures (TLS) in cutaneous squamous cell carcinoma (cSCC) and its association with clinicopathological characteristics. The results showed that TLS is highly organized in cSCC, and its presence is associated with better histopathological grades and higher sun exposure.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

Evaluation of Mast Cells in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Ashish Shrestha et al.

Summary: The study found a significant increase in mast cells in both oral potentially malignant disorders and oral squamous cell carcinoma compared to normal oral mucosa. There was a decrease in mast cell count from OPMDs to OSCC, indicating a potential protective role of mast cells in the development of oral cancer. Specific stains for quantification of mast cells may help in defining prognosis in OPMDs and oral cancer.

INTERNATIONAL JOURNAL OF DENTISTRY (2021)

Add to Collection

Article Dermatology

The Genomic Landscape of Actinic Keratosis

Jason Thomson et al.

Summary: This study conducted the largest AK whole exome sequencing study to date and found significant similarities between AK and cSCC in terms of genetic mutations, copy number alterations, driver gene mutations, and mutational signatures. The research identified 44 significantly mutated AK driver genes and suggested that dysregulated TGFf3 signaling may play an important role in AK-cSCC progression.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

Ievgenia Pastushenko et al.

Summary: This study reveals that mutation of the FAT1 gene promotes tumor initiation, progression, invasiveness, stemness, and metastasis. Loss of function of FAT1 activates a CAMK2-CD44-SRC axis while inactivates EZH2, playing important roles in the expression of YAP1 and ZEB1.

NATURE (2021)

Add to Collection

Article Oncology

Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts

Rachel A. Woolaver et al.

Summary: The study reveals that intrinsic differences in the TCR repertoire of TILs and their different transcriptional trajectories may underlie the heterogeneous antitumor immune responses in different hosts. Antitumor immune responses are highly individualized and different hosts employ different TCR specificities against the same tumors, which may have important implications for developing personalized cancer immunotherapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Xiaoqi Mao et al.

Summary: CAFs, as a crucial component of TME, play significant roles in promoting tumor growth, invasion, and metastasis. The interaction between CAFs and tumor cells, as well as immune cells in TIME, is critical for tumor progression.

MOLECULAR CANCER (2021)

Add to Collection

Review Biochemistry & Molecular Biology

New Insights Into Oral Squamous Cell Carcinoma: From Clinical Aspects to Molecular Tumorigenesis

Shang-Hung Chen et al.

Summary: Oral squamous cell carcinoma is a prevalent malignant disease worldwide, with Taiwan being particularly affected. Early detection is crucial, while understanding invasive features and the tumor microenvironment is essential for effective treatment strategies, especially for advanced cases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Multidisciplinary Sciences

Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells

Rebekka Duhen et al.

Summary: The study demonstrates that in patients with head and neck cancer, preoperative use of an OX40 antibody increases clonality, and enhances activation and proliferation of CD4+ and CD8+ T cells.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Oncology

TGFβ1 Secreted by Cancer-Associated Fibroblasts as an Inductor of Resistance to Photodynamic Therapy in Squamous Cell Carcinoma Cells

Maria Gallego-Rentero et al.

Summary: PDT is commonly used to treat cSCC, but resistance can occur due to TGF beta 1 produced by CAFs. Targeting CAF-derived TGF beta 1 may enhance PDT efficacy in cSCC treatment.

CANCERS (2021)

Add to Collection

Article Oncology

Novel TGF beta Inhibitors Ameliorate Oral Squamous Cell Carcinoma Progression and Improve the Antitumor Immune Response of Anti-PD-L1 Immunotherapy

Nils Ludwig et al.

Summary: This study found that two novel TGF beta inhibitors can reduce tumor burden and decrease body weight loss in a murine oral squamous cell carcinoma (OSCC) model, and enhance CD8(+) T-cell infiltration into tumors. Combination therapy with PD-L1 antibodies further reduces weight loss and accelerates lymphocyte infiltration into tumor tissues.

MOLECULAR CANCER THERAPEUTICS (2021)

Add to Collection

Review Oncology

The Role of Cancer-Associated Fibroblasts in Tumor Progression

Rushikesh S. Joshi et al.

Summary: The review discusses the importance of cancer-associated fibroblasts (CAFs) in various cancer contexts as potential therapeutic targets. Identification of CAFs and understanding their role in promoting tumor progression may lead to the development of novel cancer therapies.

CANCERS (2021)

Add to Collection

Review Oncology

Human cutaneous B cells: what do we really know?

Irina Lerman et al.

Summary: B cells play critical roles in the systemic immune response, but their contribution to the local immune response in non-lymphoid tissues like the skin is still not fully understood. Recent evidence suggests an important role for cutaneous B cells in skin homeostasis and disease pathogenesis, including skin infections and malignancies. Further research is needed to investigate the potential of B cell targeted therapy in dermatological conditions.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Immunology

Tumor-Associated Tertiary Lymphoid Structures: From Basic and Clinical Knowledge to Therapeutic Manipulation

Charlotte Domblides et al.

Summary: The tumor microenvironment is unique to each patient and therapies targeting tumor cells or immune cells have limited long-term benefits. Hot tumors play a role in selecting therapies targeting patient immunity, with the presence of TLS associated with better survival and predicted response to ICP inhibitors. Increasing understanding of TLS biology may improve prognostic prediction and treatment selection for cancer patients.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Review Oncology

The Role of p53 in Progression of Cutaneous Squamous Cell Carcinoma

Minna Piipponen et al.

Summary: Skin cancers, including cutaneous squamous cell carcinoma (cSCC), are the most common types of cancer worldwide, primarily caused by long-term exposure to solar ultraviolet radiation. cSCC is the most common metastatic skin cancer associated with poor prognosis. The inactivation mutation of p53 and accumulation of additional oncogenic mutations play a critical role in the progression of cSCC.

CANCERS (2021)

Add to Collection

Review Oncology

Methyltransferases in the Pathogenesis of Keratinocyte Cancers

Eun Kyung Ko et al.

Summary: Although the underlying mechanisms of skin cancers like keratinocyte cancers are still emerging, recent evidence suggests that alterations in DNA, RNA, and histone methylation may play a critical role in disrupting gene expression. While methylation modifiers are frequently dysregulated in keratinocyte cancers, the molecular and mechanistic changes are just beginning to be understood, with extensive cross-talk among these distinct methylation processes. These discoveries may lead to novel therapeutic approaches for these common cancers.

CANCERS (2021)

Add to Collection

Article Medicine, General & Internal

Relationship between Tertiary Lymphoid Structure and the Prognosis and Clinicopathologic Characteristics in Solid Tumors

Zhan Zhao et al.

Summary: The study found that high TLS expression is associated with longer overall survival and relapse-free survival in solid tumor patients, indicating a lower risk of cancer recurrence. Additionally, high TLS expression is also associated with smaller tumor size, higher infiltration of TILs, and lower clinical grading and N stage in the tumor.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

Add to Collection

Review Oncology

Molecular landscape of head and neck cancer and implications for therapy

Camile S. Farah

Summary: Head and neck squamous cell carcinomas (HNSCC) are the 6th most common human cancer, with HPV status providing clear clinical utility and prognostic benefit. HPV-negative tumors are characterized by high mutational load and chromosomal abnormalities.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Add to Collection

Review Oncology

In search of definitions: Cancer-associated fibroblasts and their markers

Martin Nurmik et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

Add to Collection

Article Allergy

Role of Mast Cells in Shaping the Tumor Microenvironment

Daniel Elieh Ali Komi et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2020)

Add to Collection

Review Dermatology

Immune checkpoint inhibitor therapy in solid organ transplant recipients: A patient-centered systematic review

Juliya Fisher et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Myeloid derived suppressor cells contribute to the malignant progression of oral squamous cell carcinoma

Xin Pang et al.

PLOS ONE (2020)

Add to Collection

Article Oncology

TGF-Beta-Activated Cancer-Associated Fibroblasts Limit Cetuximab Efficacy in Preclinical Models of Head and Neck Cancer

Ksenia M. Yegodayev et al.

CANCERS (2020)

Add to Collection

Review Cell Biology

Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses

Clement Anfray et al.

CELLS (2020)

Add to Collection

Article Oncology

Impact of Neoadjuvant Durvalumab with or without Tremelimumab on CD8+ Tumor Lymphocyte Density, Safety, and Efficacy in Patients with Oropharynx Cancer: CIAO Trial Results

Renata Ferrarotto et al.

CLINICAL CANCER RESEARCH (2020)

Add to Collection

Review Medicine, General & Internal

Deciphering the Molecular Landscape of Cutaneous Squamous Cell Carcinoma for Better Diagnosis and Treatment

Andreea D. Lazar et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

The tumor immune microenvironment and its implications for clinical outcome in patients with oropharyngeal squamous cell carcinoma

Dominik Gurin et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The tumor microenvironment

Nicole M. Anderson et al.

CURRENT BIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

Angelo L. Grauel et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Medicine, General & Internal

Head and neck squamous cell carcinoma

Daniel E. Johnson et al.

NATURE REVIEWS DISEASE PRIMERS (2020)

Add to Collection

Editorial Material Oncology

TGF-β Mediated Immune Evasion in Cancer-Spotlight on Cancer-Associated Fibroblasts

Parisa Ghahremanifard et al.

CANCERS (2020)

Add to Collection

Review Cell Biology

NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma

Pooja A. Shah et al.

CELLS (2020)

Add to Collection

Review Medicine, General & Internal

Head and Neck Cancer

Laura Q. M. Chow

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Article Oncology

Management of the Neck in Squamous Cell Carcinoma of the Oral Cavity and Oropharynx: ASCO Clinical Practice Guideline

Shlomo A. Koyfman et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

The Role of the Immune System in Cutaneous Squamous Cell Carcinoma

Matthew J. Bottomley et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Review Dermatology

Review and Update on Evidence-Based Surgical Treatment Recommendations for Nonmelanoma Skin Cancer

Megan E. Shelton et al.

DERMATOLOGIC CLINICS (2019)

Add to Collection

Review Oncology

The changing therapeutic landscape of head and neck cancer

John D. Cramer et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Add to Collection

Review Immunology

Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression

Antonino Bruno et al.

FRONTIERS IN IMMUNOLOGY (2019)

Add to Collection

Article Oncology

Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells

Kamila Hladikova et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Add to Collection

Article Oncology

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

J. Ferlay et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Extracellular matrix (ECM) stiffness and degradation as cancer drivers

Masoud Najafi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Add to Collection

Article Dermatology

Immune Checkpoint Inhibitors for Treating Advanced Cutaneous Squamous Cell Carcinoma

Roma Patel et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2019)

Add to Collection

Review Oncology

Tertiary lymphoid structures in the era of cancer immunotherapy

Catherine Sautes-Fridman et al.

NATURE REVIEWS CANCER (2019)

Add to Collection

Article Oncology

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4

Christopher J. Hanley et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Add to Collection

Article Oncology

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4

Christopher J. Hanley et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

Add to Collection

Review Developmental Biology

Dermal fibroblast in cutaneous development and healing

Venkata Thulabandu et al.

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion

Andreas Stylianou et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)

Add to Collection

Article Oncology

Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression

Dhruv Kumar et al.

CANCER RESEARCH (2018)

Add to Collection

Article Pathology

Analysis of cancer-associated fibroblasts and the epithelial-mesenchymal transition in cutaneous basal cell carcinoma, squamous cell carcinoma, and malignant melanoma

Kousuke Sasaki et al.

HUMAN PATHOLOGY (2018)

Add to Collection

Review Dentistry, Oral Surgery & Medicine

The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma

T. Fukusumi et al.

JOURNAL OF DENTAL RESEARCH (2018)

Add to Collection

Article Multidisciplinary Sciences

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

Daniel Martin et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article

High infiltration of CD68+ macrophages is associated with poor prognoses of head and neck squamous cell carcinoma patients and is influenced by human papillomavirus

Imelda Seminerio et al.

Oncotarget (2018)

Add to Collection

Review Oncology

PD-1/PD-L1 pathway blockade works as an effective and practical therapy for cancer immunotherapy

Long Jia et al.

CANCER BIOLOGY & MEDICINE (2018)

Add to Collection

Article Multidisciplinary Sciences

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Gareth J. Inman et al.

NATURE COMMUNICATIONS (2018)

Add to Collection

Article Materials Science, Biomaterials

Probing Fibroblast Activation in Response to Extracellular Cues with Whole Protein - or Peptide-Functionalized Step-Growth Hydrogels

Megan E. Smithmyer et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Role of Extracellular Matrix in Development and Cancer Progression

Cameron Walker et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Add to Collection

Review Medicine, General & Internal

Pathogenesis of Skin Carcinomas and a Stem Cell as Focal Origin

Frank R. de Gruijl et al.

FRONTIERS IN MEDICINE (2018)

Add to Collection

Review Oncology

The molecular landscape of head and neck cancer

C. Rene Leemans et al.

NATURE REVIEWS CANCER (2018)

Add to Collection

Review Oncology

Deciphering the cells of origin of squamous cell carcinomas

Adriana Sanchez-Danes et al.

NATURE REVIEWS CANCER (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Effect of Stromal Cells in Tumor Microenvironment on Metastasis Initiation

Sen Guo et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Add to Collection

Review Otorhinolaryngology

Reviewing the genetic alterations in high-risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets

Bruce G. Ashford et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2017)

Add to Collection

Article Oncology

PD-L1 induced by IFN-γ from tumor-associated macrophages via the JAK/STAT3 and PI3K/AKT signaling pathways promoted progression of lung cancer

Xiaohui Zhang et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2017)

Add to Collection

Article Oncology

Prognostic significance of tumor infiltrating immune cells in oral squamous cell carcinoma

Juan Fang et al.

BMC CANCER (2017)

Add to Collection

Review Dermatology

Nonmelanoma skin cancer and risk of all-cause and cancer-related mortality: a systematic review

Virginia Barton et al.

ARCHIVES OF DERMATOLOGICAL RESEARCH (2017)

Add to Collection

Review Oncology

Notch as a tumour suppressor

Craig S. Nowell et al.

NATURE REVIEWS CANCER (2017)

Add to Collection

Review Oncology

Squamous Cell Cancers: A Unified Perspective on Biology and Genetics

G. Paolo Dotto et al.

CANCER CELL (2016)

Add to Collection

Review Cell Biology

Fibroblast activation in cancer: when seed fertilizes soil

Sanya-Eduarda Kuzet et al.

CELL AND TISSUE RESEARCH (2016)

Add to Collection

Article Dermatology

Cutaneous squamous cell carcinomas with markers of increased metastatic risk are associated with elevated numbers of neutrophils and/or granulocytic myeloid derived suppressor cells

Annika Seddon et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2016)

Add to Collection

Article Oncology

Tumor- associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

Yong Hu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2016)

Add to Collection

Article Oncology

Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial

Tanguy Y. Seiwert et al.

LANCET ONCOLOGY (2016)

Add to Collection

Review Oncology

Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma

Paolo Bossi et al.

ONCOTARGET (2016)

Add to Collection

Review Oncology

The biology and function of fibroblasts in cancer

Raghu Kalluri

NATURE REVIEWS CANCER (2016)

Add to Collection

Article Medicine, Research & Experimental

Specific inhibition of fibroblast activation protein (FAP)-alpha prevents tumor progression in vitro

Volker Teichgraeber et al.

ADVANCES IN MEDICAL SCIENCES (2015)

Add to Collection

Article Oncology

Genomic Analysis of Metastatic Cutaneous Squamous Cell Carcinoma

Yvonne Y. Li et al.

CLINICAL CANCER RESEARCH (2015)

Add to Collection

Article Multidisciplinary Sciences

Comprehensive genomic characterization of head and neck squamous cell carcinomas

Michael S. Lawrence et al.

NATURE (2015)

Add to Collection

Review Cell Biology

Understanding fibroblast heterogeneity in the skin

Ryan R. Driskell et al.

TRENDS IN CELL BIOLOGY (2015)

Add to Collection

Article Immunology

IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration

Naoyuki Makita et al.

INTERNATIONAL IMMUNOLOGY (2015)

Add to Collection

Article Otorhinolaryngology

Enhancement of head and neck squamous cell carcinoma proliferation, invasion, and metastasis by tumor-associated fibroblasts in preclinical models

Sarah Elizabeth Wheeler et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2014)

Add to Collection

Article Dermatology

Gene Expression Profiling of the Leading Edge of Cutaneous Squamous Cell Carcinoma: IL-24-Driven MMP-7

Hiroshi Mitsui et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

Add to Collection

Article Oncology

Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis

Iris Eke et al.

CANCER RESEARCH (2013)

Add to Collection

Article Oncology

Integrin αvβ3 and Fibronectin Upregulate Slug in Cancer Cells to Promote Clot Invasion and Metastasis

Lynn M. Knowles et al.

CANCER RESEARCH (2013)

Add to Collection

Article Oncology

Basal stem cells contribute to squamous cell carcinomas in the oral cavity

Xiao-Han Tang et al.

CARCINOGENESIS (2013)

Add to Collection

Article Oncology

Transforming growth factor-β1 treatment of oral cancer induces epithelial-mesenchymal transition and promotes bone invasion via enhanced activity of osteoclasts

Jingjing Quan et al.

CLINICAL & EXPERIMENTAL METASTASIS (2013)

Add to Collection

Article Medicine, Research & Experimental

STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients

David Vasquez-Dunddel et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Add to Collection

Article Dentistry, Oral Surgery & Medicine

Biomarkers of Epithelial-Mesenchymal Transition in Squamous Cell Carcinoma

C. S. Scanlon et al.

JOURNAL OF DENTAL RESEARCH (2013)

Add to Collection

Review Oncology

Macrophage plasticity and polarization in tissue repair and remodelling

Alberto Mantovani et al.

JOURNAL OF PATHOLOGY (2013)

Add to Collection

Article Medicine, General & Internal

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

Daniel D. Von Hoff et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Add to Collection

Article Multidisciplinary Sciences

Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

Christine Feig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Add to Collection

Article Oncology

Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers

Curtis R. Pickering et al.

CANCER DISCOVERY (2013)

Add to Collection

Article Dermatology

Factors Predictive of Recurrence and Death From Cutaneous Squamous Cell Carcinoma A 10-Year, Single-Institution Cohort Study

Chrysalyne D. Schmults et al.

JAMA DERMATOLOGY (2013)

Add to Collection

Article Oncology

Functional invadopodia formation through stabilization of the PDPN transcript by IMP-3 and cancer-stromal crosstalk for PDPN expression

Young Sun Hwang et al.

CARCINOGENESIS (2012)

Add to Collection

Article Oncology

Cancer-Associated Fibroblasts Induce Matrix Metalloproteinase-Mediated Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cells

Ann-Charlotte Johansson et al.

MOLECULAR CANCER RESEARCH (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Differential Roles of T-cell Subsets in Regulation of Ultraviolet Radiation Induced Cutaneous Photocarcinogenesis

Tahseen H. Nasti et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2011)

Add to Collection

Article Oncology

Oropharyngeal carcinoma in non-smokers and non-drinkers: A role for HPV

Elizabeth Andrews et al.

ORAL ONCOLOGY (2009)

Add to Collection

Review Immunology

PD-1 and its ligands in tolerance and immunity

Mary E. Keir et al.

ANNUAL REVIEW OF IMMUNOLOGY (2008)

Add to Collection

Article Oncology

HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

Rose Du et al.

CANCER CELL (2008)

Add to Collection

Article Oncology

Photodynamic therapy of cancer.: Basic principles and applications

Angeles Juarranz et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2008)

Add to Collection

Article Immunology

Subsets of myeloid-derived suppressor cells in tumor-bearing mice

Je-In Youn et al.

JOURNAL OF IMMUNOLOGY (2008)

Add to Collection

Review Oncology

New roles for integrins in squamous-cell carcinoma

SM Jones et al.

NATURE REVIEWS CANCER (2006)

Add to Collection

Letter Oncology

Three cases of activation of cutaneous squamous-cell carcinoma during treatment with prolonged administration of rituximab

GB Fogarty et al.

CLINICAL ONCOLOGY (2006)

Add to Collection

Article Medicine, General & Internal

Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

JA Bonner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Add to Collection

Article Oncology

Mortality risk from squamous cell skin cancer

GL Clayman et al.

JOURNAL OF CLINICAL ONCOLOGY (2005)

Add to Collection

Article Cell Biology

Mast cell-mediated apoptosis of endothelial cells in vitro:: A paracrine mechanism involving TNF-α-mediated down-regulation of bcl-2 expression

S Lätti et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2003)

Add to Collection

Review Oncology

Papillomaviruses and cancer: From basic studies to clinical application

H zur Hausen

NATURE REVIEWS CANCER (2002)

Add to Collection

Review Medicine, General & Internal

Primary care: Cutaneous squamous-cell carcinoma

M Alam et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.