4.6 Article

Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma

Related references

Note: Only part of the references are listed.
Article Genetics & Heredity

Molecularly Guided Drug Repurposing for Cholangiocarcinoma: An Integrative Bioinformatic Approach

Simran Venkatraman et al.

Summary: This study utilized transcriptomic data and bioinformatic methods to repurpose FDA-approved drugs for cholangiocarcinoma (CCA) treatment, identifying high-risk patients through an immune-oncogenic gene signature and identifying 8 FDA-approved drugs as promising candidates for potential use in treatment.

GENES (2022)

Article Chemistry, Medicinal

RTK25: A Comprehensive Molecular Profiling Strategy in Cholangiocarcinoma Using an Integrated Bioinformatics Approach

Brinda Balasubramanian et al.

Summary: Cholangiocarcinoma (CCA) is a diverse group of malignancies originating from the bile duct, with tumor heterogeneity hindering the feasibility of precision oncology. Stratifying patients based on molecular features and biomarkers offers a potential solution. The study identified five distinct molecular subtypes of CCA based on gene expression profiles of selected RTKs, suggesting tailored dual inhibition of RTKs may be more favorable than monotherapy for this type of cancer.

PHARMACEUTICALS (2021)

Review Oncology

FGFR-TKI resistance in cancer: current status and perspectives

Sitong Yue et al.

Summary: This review discusses the mechanisms of resistance to FGFR-TKI in cancer and strategies to overcome resistance, including gatekeeper mutations, alternative signaling pathway activation, lysosome-mediated TKI sequestration, and gene fusion. Potential strategies to overcome resistance include developing covalent inhibitors, dual-target inhibitors, combination therapy, and targeting lysosomes to transition to precision medicine and individualized treatment.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Oncology

Survival after surgery among patients with cholangiocarcinoma in Northeast Thailand according to anatomical and morphological classification

Chaiwat Tawarungruang et al.

Summary: Among CCA patients who underwent curative surgery, those in the PCCA+ID group showed the highest 5-year survival rate, while patients in the ICCA+MF group tended to have unfavorable outcomes. Therefore, further research should focus on patients with a combination of anatomical and morphological classifications.

BMC CANCER (2021)

Review Oncology

Next-Generation Biomarkers for Cholangiocarcinoma

Pedro M. Rodrigues et al.

Summary: The early and non-invasive diagnosis of cholangiocarcinoma (CCA) remains a challenge, contributing to increased mortality rates globally. Efforts to identify novel biomarkers for CCA diagnosis and prognosis prediction are ongoing, with the hope of improving patient outcomes in the future. High-throughput omics-based approaches hold promise for identifying circulating biomarkers that may aid in early detection and treatment stratification in large-scale validation studies.

CANCERS (2021)

Article Biochemistry & Molecular Biology

SynergyFinder 2.0: visual analytics of multi-drug combination synergies

Aleksandr Ianevski et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Gastroenterology & Hepatology

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

Jesus M. Banales et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Biochemistry & Molecular Biology

Chemoresistance and chemosensitization in cholangiocarcinoma

Jose J. G. Marin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Gastroenterology & Hepatology

Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

Jesus M. Banales et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

Article Biochemistry & Molecular Biology

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Maxim V. Kuleshov et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemical Research Methods

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

Edward Y. Chen et al.

BMC BIOINFORMATICS (2013)

Review Oncology

Fibroblast growth factor signalling: from development to cancer

Nicholas Turner et al.

NATURE REVIEWS CANCER (2010)

Review Cell Biology

STAT3 as a target for inducing apoptosis in solid and hematological tumors

Khandaker Al Zaid Siddiquee et al.

CELL RESEARCH (2008)

Article Surgery

Cholangiocarcinoma - Thirty-one-year experience with 564 patients at a single institution

Michelle L. DeOliveira et al.

ANNALS OF SURGERY (2007)