4.6 Review

Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics

Related references

Note: Only part of the references are listed.
Review Cell Biology

Multifaceted roles of TAX1BP1 in autophagy

Jesse White et al.

Summary: TAX1BP1 is a crucial autophagy receptor that plays a central role in host defense and regulating the immune system. In addition to its canonical functions, TAX1BP1 also influences the biogenesis and maturation of autophagosomes.

AUTOPHAGY (2023)

Article Cell Biology

CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma

Jingyue Yao et al.

Summary: The study revealed that CDK9 inhibitors blocked PINK1-PRKN-mediated mitophagy in HCC, promoting mitochondrial dysfunction and cell death. A novel CDK9 inhibitor, oroxylin A (OA), showed strong therapeutic potential against HCC, overcoming drug resistance without extreme repression of general transcription associated with existing CDK9 inhibitors.

AUTOPHAGY (2022)

Article Biochemistry & Molecular Biology

Mechanism of Atg9 recruitment by Atg11 in the cytoplasm-to-vacuole targeting pathway

Nicolas Coudevylle et al.

Summary: Autophagy is a degradation pathway that removes damaged and excess cytoplasmic material. The interaction between the scaffold protein Atg11 and the transmembrane protein Atg9 plays a crucial role in selective autophagy.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Article Oncology

Autophagy inhibits cancer stemness in triple-negative breast cancer via miR-181a-mediated regulation of ATG5 and/or ATG2B

Jee Won Park et al.

Summary: Autophagy flux differs between luminal and triple-negative breast cancers. miR-181a regulates autophagy-related proteins ATG5 and ATG2B, which are associated with cancer stemness in TNBC. Curcumin promotes autophagy flux and attenuates cancer stemness in TNBC.

MOLECULAR ONCOLOGY (2022)

Article Oncology

USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-κB activation and autophagy induction by TLR4

Mi-Jeong Kim et al.

Summary: The study revealed that USP8 is involved in liver cancer progression through TRAF6-mediated signal, regulating NF-kappa B activation and autophagy induction. The findings suggest that USP8 plays a negative role in LIHC progression by activating the TRAF6-mediated signal.

TRANSLATIONAL ONCOLOGY (2022)

Article Cell Biology

TRK-fused gene (TFG) regulates ULK1 stability via TRAF3-mediated ubiquitination and protects macrophages from LPS-induced pyroptosis

Jian-Hong Shi et al.

Summary: TFG plays an essential role in LPS/Ng-induced pyroptotic cell death by regulating the stability of ULK1.

CELL DEATH & DISEASE (2022)

Article Oncology

被撤回的出版物: PINK1 deficiency in gastric cancer compromises mitophagy, promotes the Warburg effect, and facilitates M2 polarization of macrophages (Retracted article. See vol. 549, 2022)

Ying Xu et al.

Summary: PINK1 loss leads to mitophagy defects and metabolic reprogramming in gastric cancer, which promotes polarization of tumor-associated macrophages and remodeling of the tumor microenvironment, contributing to GC progression.

CANCER LETTERS (2022)

Article Cell Biology

USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction

Mi-Jeong Kim et al.

Summary: The study reveals that USP15 is significantly downregulated in lung cancer patients, and its knockout leads to increased migration, invasion, and autophagy induction in lung cancer cells. USP15 interacts with BECN1 and deubiquitinates it, thereby attenuating autophagy induction. Additionally, the expression of USP15 is associated with the upregulation of certain oncogenes and downregulation of tumor suppressor genes in lung cancer patients.

CELL DEATH & DISEASE (2022)

Article Cell Biology

TMEM189 negatively regulates the stability of ULK1 protein and cell autophagy

Jiahong Yu et al.

Summary: In this study, it was discovered that TMEM189 negatively regulates the proteostasis of ULK1 and autophagy activity by interacting with ULK1 and reducing its stability and kinase activities. TMEM189 deficiency also inhibits tumorigenicity of gastric cancer. These findings provide insights into the molecular regulation of autophagy and the physiological and pathological roles of TMEM189.

CELL DEATH & DISEASE (2022)

Review Biochemistry & Molecular Biology

Mitochondrial E3 ubiquitin ligase 1 (MUL1) as a novel therapeutic target for diseases associated with mitochondrial dysfunction

Ximena Calle et al.

Summary: MUL1 is a protein involved in various cellular processes, including mitochondrial dynamics, cell survival, and tumor suppression. It plays a role in inflammatory response, cancer, neurological diseases, and cardiovascular diseases. This review summarizes the functions of MUL1 in different pathological models and discusses its potential as a therapeutic target.

IUBMB LIFE (2022)

Review Cell Biology

Multiple functions of CALCOCO family proteins in selective autophagy

Wei Chen et al.

Summary: Selective autophagy is a process in which specific intracellular components are degraded through the activity of selective autophagy receptors. CALCOCO family proteins are newly identified receptors that play important roles in different selective autophagy pathways, including ER-phagy, Golgiphagy, mitophagy, and xenophagy. These proteins interact with ATG8/LC3 and ubiquitin to mediate cargo recruitment and degradation.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

Article Biochemistry & Molecular Biology

PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cells

Natsumi Miyazaki et al.

Summary: Cancer cells rely on glycolysis to generate ATP for survival, but metabolic reprogramming involves mitophagy in mitochondrial activation, providing a potential strategy for cancer therapy.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Article Cell Biology

The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization

Quanfu Li et al.

Summary: This study identifies a novel role of mucin 1 (MUC1) in promoting mitophagy and maintaining the malignancy of cancer cells. MUC1 interacts with ATPase family AAA domain-containing 3A (ATAD3A) and induces its degradation, resulting in protection of PTEN-induced kinase 1 (Pink1) from ATAD3A-mediated cleavage. Inhibition of mitophagy suppresses MUC1-induced cancer cell activity. The findings provide a new therapeutic approach for MUC1-positive cancers.

CELL DEATH & DISEASE (2022)

Review Cell Biology

The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?

Marine Jacquet et al.

Summary: Atg8-family proteins, including GABARAP and LC3, play crucial roles in autophagy and cancer. While downregulation of GABARAPs is associated with cancer progression, the expression of LC3s does not correlate with specific tumor types or stages. The exact role of Atg8-family proteins in cancer remains unclear, but it seems to be related to their involvement in selective protein degradation through autophagy.

AUTOPHAGY (2021)

Article Cell Biology

High-throughput screening of functional deubiquitinating enzymes in autophagy

Shuo Tian et al.

Summary: This study identified previously unrecognized roles of deubiquitinating enzymes in modulating autophagy and provided insights into the critical roles of reversible ubiquitination in modifying ATG proteins.

AUTOPHAGY (2021)

Article Cell Biology

LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13

Yuanyuan Chu et al.

Summary: The study reveals that LUBAC and OTULIN cooperatively regulate autophagy initiation and autophagosome maturation by mediating the linear ubiquitination and stabilization of ATG13.

AUTOPHAGY (2021)

Review Cell Biology

New insights regarding SNARE proteins in autophagosome-lysosome fusion

Xiaoyu Tian et al.

Summary: Macroautophagy/autophagy is a cellular mechanism for the degradation of cellular contents, with the final step being the fusion of autophagosome with the lysosome mediated by SNARE proteins. In addition to regulating autophagosome-lysosome fusion, some SNAREs are also involved in other autophagic processes, controlling fusion process spatially and temporally.

AUTOPHAGY (2021)

Article Cell Biology

The conformational and mutational landscape of the ubiquitin-like marker for autophagosome formation in cancer

Burcu Aykac Fas et al.

Summary: This study investigates the structural impact of mutations in MAP1LC3B protein in cancer samples, providing insight into detrimental or neutral mutations. Through biomolecular simulations and experimental validation, the study sheds light on the damaging effects of certain mutations and offers an atlas of modifications in cancer-related MAP1LC3B mutations.

AUTOPHAGY (2021)

Article Oncology

STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib

Yahui Zheng et al.

Summary: The study revealed that overexpression of STOML2 in HCC is associated with metastasis, poor overall survival, and higher recurrence rates. Upregulation of STOML2 accelerates colony formation, migration, and invasion of HCC cells.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Multidisciplinary Sciences

BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects

Gee Euhn Choi et al.

Summary: The study found that glucocorticoids inhibit NIX-dependent basal mitophagy, leading to reduced synaptic density and neurodegeneration, which can be reversed in a mouse model by pretreatment with a NIX enhancer.

NATURE COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

Mitophagy in tumorigenesis and metastasis

Logan P. Poole et al.

Summary: Cells utilize mitophagy to remove dysfunctional or excess mitochondria in response to external stresses, with mechanisms including mitochondrial cargo receptors induced by these stresses, mitochondrial protein targets of PINK1/Parkin phospho-ubiquitination, and mitochondrial lipid signaling. These pathways play a crucial role in tumorigenesis, metastasis, cell cycle control, survival pathways, and therapy responses in cancer. Mitophagy also impacts tissue atrophy during cancer cachexia and clinical therapy responses.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Multidisciplinary Sciences

VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism

Yu-Hsuan Chen et al.

Summary: The study reveals that branched ubiquitination of VPS34 acts as a switch between UPS and autophagy, playing an important role in lipid metabolism in the liver.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation

Zixuan Zhou et al.

Summary: The study uncovers a general and phosphoregulatable binding mode between FIP200 Claw and many autophagy receptors for autophagosome biogenesis, shedding light on the detailed molecular mechanism and potential regulatory pathways involved in the interactions.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

The autophagy protein ATG9A enables lipid mobilization from lipid droplets

Elodie Mailler et al.

Summary: ATG9A is a transmembrane protein involved in lipid mobilization, essential for autophagosome expansion, mitochondrial fatty acid import, and beta-oxidation. Depletion of ATG9A inhibits autophagy, increases lipid droplet size/number, and blocks transfer of fatty acids to mitochondria. ATG9A localizes to vesicular-tubular clusters associated with TMEM41B and plays a critical role in lipid mobilization from lipid droplets to autophagosomes and mitochondria.

NATURE COMMUNICATIONS (2021)

Review Medicine, Research & Experimental

Dualistic role of autophagy in cancer progression

Kacper Turek et al.

Summary: Autophagy plays a dualistic role in carcinogenesis by regulating cell survival and death. While it can suppress cancer in early stages by maintaining genomic integrity, it may also promote tumor progression once cancer has developed. Furthermore, autophagy can affect the response of tumor cells to therapy, leading to resistance and reduced susceptibility to anticancer drugs. Further research is needed to understand the molecular mechanisms of autophagy and its potential applications in cancer treatment and prevention.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE (2021)

Article Cell Biology

CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression

Xuan Li et al.

Summary: The E3 ubiquitin ligase CUL3 interacts with BECN1 to promote its ubiquitination and degradation, leading to a decrease in autophagic activity and promoting tumor cell proliferation. Additionally, KLHL38 acts as a substrate adaptor for the CUL3 E3 ligase complex-mediated degradation of BECN1.

AUTOPHAGY (2021)

Article Multidisciplinary Sciences

The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D

Andrea C. Chaikovsky et al.

Summary: Levels of cyclin D are linked to lung adenocarcinoma development and cellular response to CDK4/6 inhibitors, with AMBRA1 playing a key role in the degradation of cyclin D.

NATURE (2021)

Article Biochemistry & Molecular Biology

ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells

JaeYung Lee et al.

Summary: The research suggests that HUWE1 suppresses autophagy by ubiquitinating and degrading ATG101 and WIPI2, thereby inhibiting the survival of cancer cells; meanwhile, ATG101-mediated autophagy may play a critical role in overcoming metabolic stress, and promoting the growth, survival, and treatment resistance of certain cancers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Cyclovirobuxine D Induced-Mitophagy through the p65/BNIP3/LC3 Axis Potentiates Its Apoptosis-Inducing Effects in Lung Cancer Cells

Cheng Zeng et al.

Summary: This study demonstrates that CVB-D can induce mitophagy in lung cancer cells by activating the p65/BNIP3/LC3 axis, leading to enhanced apoptosis and inhibited tumor growth.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Vps13D functions in a Pink1-dependent and Parkin-independent mitophagy pathway

James L. Shen et al.

Summary: Defects in autophagy can lead to issues in metabolism, development, and disease. The loss of Vps13D affects mitophagy, regulated by the core autophagy machinery. Pink1 and Vps13D play roles in Pink1-dependent mitophagy, with Park contributing to mitochondrial clearance through a pathway parallel to Vps13D.

JOURNAL OF CELL BIOLOGY (2021)

Article Cell Biology

Melatonin inhibits triple-negative breast cancer progression through the Lnc049808-FUNDC1 pathway

Anli Yang et al.

Summary: Melatonin treatment downregulated FUNDC1 and lnc049808 in TNBC cell lines, which inhibited cell proliferation, invasion, and metastasis. lnc049808 and FUNDC1 acted as competing endogenous RNAs binding to miR-101, indicating a potential therapeutic pathway for TNBC progression inhibition by melatonin.

CELL DEATH & DISEASE (2021)

Article Biology

Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

Lisa M. Strong et al.

Summary: The study elucidates the recruitment mechanism of ATG12-5-16L1 on the autophagosomal membrane through the binding of ATG16L1 with WIPI2d, providing a framework for understanding the regulatory node connecting the initiation of autophagy.

ELIFE (2021)

Article Multidisciplinary Sciences

A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression

Ekta Agarwal et al.

Summary: Parkin, an E3 ubiquitin ligase altered in Parkinson's disease, is shown to suppress tumor growth by shutting off mitochondrial dynamics and inhibiting the non-oxidative phase of the pentose phosphate pathway. This tumor suppression function of Parkin requires its E3 ligase activity and can be reversed by antioxidants, independently of mitophagy. Cancer metabolic networks are identified as potential oncogenes directly targeted by endogenous tumor suppression mechanisms.

SCIENCE ADVANCES (2021)

Review Cell Biology

Binding Features and Functions of ATG3

Dongmei Fang et al.

Summary: ATG3 plays a crucial role in autophagosome formation, contributing to various physiological and pathological processes such as tumor progression, ischemia-reperfusion injury, and organelle homeostasis. Additionally, ATG3 has been found to have autophagy-independent functions, including roles in cell differentiation and mitosis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Cell Biology

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky et al.

Summary: The guidelines presented in this article aim to assist researchers in selecting and interpreting methods to examine autophagy, as well as to help reviewers provide constructive critiques of reports focused on these processes. It emphasizes that no single assay is perfect for every situation, and multiple techniques may be needed to properly monitor autophagy in different experimental settings. The article also highlights the importance of targeting multiple autophagy-related genes in genetic approaches to block autophagy effectively.

AUTOPHAGY (2021)

Editorial Material Cell Biology

Regulation of LC3B levels by ubiquitination and proteasomal degradation

Rui Jia et al.

AUTOPHAGY (2020)

Editorial Material Biochemistry & Molecular Biology

Getting Close: Insight into the Structure and Function of K11/K48-Branched Ubiquitin Chains

Regina Baur et al.

STRUCTURE (2020)

Article Biochemistry & Molecular Biology

PINK1 phosphorylates Drp1S616 to regulate mitophagy-independent mitochondrial dynamics

Hailong Han et al.

EMBO REPORTS (2020)

Review Biochemistry & Molecular Biology

The role of ubiquitination and deubiquitination in cancer metabolism

Tianshui Sun et al.

MOLECULAR CANCER (2020)

Article Biochemistry & Molecular Biology

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

Amelia E Ohnstad et al.

EMBO JOURNAL (2020)

Review Cell Biology

Mitophagy Receptors in Tumor Biology

Yangchun Xie et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Cell Biology

Roles of ubiquitin in autophagy and cell death

Carlos Gomez-Diaz et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers

Conan G. Kinsey et al.

NATURE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Atg2 mediates direct lipid transfer between membranes for autophagosome formation

Takuo Osawa et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Article Multidisciplinary Sciences

Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production

Aurora Scrivo et al.

NATURE COMMUNICATIONS (2019)

Article Cell Biology

NIPSNAP1 and NIPSNAP2 Act as Eat Me Signals for Mitophagy

Yakubu Princely Abudu et al.

DEVELOPMENTAL CELL (2019)

Article Biochemistry & Molecular Biology

Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins

Alexander Agrotis et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Oncology

Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Timothy J. Humpton et al.

CANCER DISCOVERY (2019)

Article Oncology

EI24, as a Component of Autophagy, Is Involved in Pancreatic Cell Proliferation

Mihwa Hwang et al.

FRONTIERS IN ONCOLOGY (2019)

Review Oncology

Targeting Autophagy in Cancer: Recent Advances and Future Directions

Ravi K. Amaravadi et al.

CANCER DISCOVERY (2019)

Article Cell Biology

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

Sarbajeet Nagdas et al.

CELL REPORTS (2019)

Article Multidisciplinary Sciences

Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress

Natalia Oleinik et al.

SCIENCE ADVANCES (2019)

Review Cell Biology

Ubiquitin-mediated regulation of autophagy

Ruey-Hwa Chen et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

Review Biochemistry & Molecular Biology

Ubiquitin signaling and autophagy

Paolo Grumati et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Biotechnology & Applied Microbiology

Deubiquitylating enzymes and drug discovery: emerging opportunities

Jeanine A. Harrigan et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Cell Biology

Systematic analysis of ATG13 domain requirements for autophagy induction

Nora Wallot-Hieke et al.

AUTOPHAGY (2018)

Review Biochemistry & Molecular Biology

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

Sarah Pickles et al.

CURRENT BIOLOGY (2018)

Article Biochemistry & Molecular Biology

The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation

Jun Hwan Kim et al.

EMBO REPORTS (2018)

Review Cell Biology

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Konstantinos Palikaras et al.

NATURE CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux

Wei Wan et al.

MOLECULAR CELL (2018)

Review Cell Biology

Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System

Nur Mehpare Kocaturk et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA

L-Z Xu et al.

ONCOGENE (2017)

Review Biochemistry & Molecular Biology

Parkin and mitophagy in cancer

J. P. Bernardini et al.

ONCOGENE (2017)

Article Biochemistry & Molecular Biology

Cytosolic BNIP3 Dimer Interacts with Mitochondrial BAX Forming Heterodimers in the Mitochondrial Outer Membrane under Basal Conditions

Ulrike B. Hendgen-Cotta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biochemistry & Molecular Biology

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

Martin A. Michel et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

Polyglutamine tracts regulate beclin 1-dependent autophagy

Avraham Ashkenazi et al.

NATURE (2017)

Article Multidisciplinary Sciences

A pathology atlas of the human cancer transcriptome

Mathias Uhlen et al.

SCIENCE (2017)

Review Oncology

Expanding perspectives on the significance of mitophagy in cancer

Lauren E. Drake et al.

SEMINARS IN CANCER BIOLOGY (2017)

Article Multidisciplinary Sciences

Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression

Juan Liu et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins

Alice C. Newman et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

FKBP8 recruits LC3A to mediate Parkin-independent mitophagy

Zambarlal Bhujabal et al.

EMBO REPORTS (2017)

Article Biochemistry & Molecular Biology

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy

Ziheng Chen et al.

EMBO REPORTS (2017)

Article Biochemistry & Molecular Biology

Mitophagy: Link to cancer development and therapy

Andrey V. Kulikov et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

Yongjie Wei et al.

Review Biochemistry & Molecular Biology

SNARE zippering

Xiaochu Lou et al.

BIOSCIENCE REPORTS (2016)

Review Biochemistry & Molecular Biology

p62 in Cancer: Signaling Adaptor Beyond Autophagy

Jorge Moscat et al.

Article Biochemistry & Molecular Biology

USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin-1

Shouheng Jin et al.

EMBO JOURNAL (2016)

Review Pharmacology & Pharmacy

Time to use a dose of Chloroquine as an adjuvant to anti-cancer chemotherapies

Steve Pascolo

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

Article Cell Biology

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

Daichao Xu et al.

GENES & DEVELOPMENT (2016)

Article Biochemistry & Molecular Biology

The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway

Raymonde Szargel et al.

HUMAN MOLECULAR GENETICS (2016)

Article Cell Biology

NBR1 enables autophagy-dependent focal adhesion turnover

Candia M. Kenific et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Cell Biology

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation

Francesca Nazio et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility

Evgeny Shlevkov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Pharmacology & Pharmacy

Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease

Rebecca A. Barnard et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)

Article Biochemistry & Molecular Biology

AMBRA1 and SQSTM1 expression pattern in prostate cancer

Laura Falasca et al.

APOPTOSIS (2015)

Review Chemistry, Medicinal

Integrating autophagy and metabolism in cancer

Heesun Cheong

ARCHIVES OF PHARMACAL RESEARCH (2015)

Article Cell Biology

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

Yuqing Wang et al.

AUTOPHAGY (2015)

Correction Biochemistry & Molecular Biology

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1 (vol 22, pg 419, 2015)

F. Strappazzon et al.

CELL DEATH AND DIFFERENTIATION (2015)

Review Biochemistry & Molecular Biology

Autophagy signal transduction by ATG proteins: from hierarchies to networks

Sebastian Wesselborg et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

Review Oncology

Deubiquitinases and the new therapeutic opportunities offered to cancer

Roland Pfoh et al.

ENDOCRINE-RELATED CANCER (2015)

Review Chemistry, Medicinal

Targeting ubiquitination for cancer therapies

John Kenneth Morrow et al.

FUTURE MEDICINAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response

Andrew E. H. Elia et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

Jiajie Diao et al.

NATURE (2015)

Article Cell Biology

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

Christian N. Cunningham et al.

NATURE CELL BIOLOGY (2015)

Article Multidisciplinary Sciences

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

Jinghui Zhao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Cell Biology

Cellular and metabolic functions for autophagy in cancer cells

Candia M. Kenific et al.

TRENDS IN CELL BIOLOGY (2015)

Article Multidisciplinary Sciences

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

Tomokazu Murakawa et al.

NATURE COMMUNICATIONS (2015)

Review Cell Biology

Atg7 in development and disease: panacea or Pandora's Box?

Jianhua Xiong

PROTEIN & CELL (2015)

Review Cell Biology

The machinery of macroautophagy

Yuchen Feng et al.

CELL RESEARCH (2014)

Article Biochemistry & Molecular Biology

PMI: A ΔΨm Independent Pharmacological Regulator of Mitophagy

Daniel A. East et al.

CHEMISTRY & BIOLOGY (2014)

Article Cell Biology

AMBRA1 Interplay with Cullin E3 Ubiquitin Ligases Regulates Autophagy Dynamics

Manuela Antonioli et al.

DEVELOPMENTAL CELL (2014)

Article Biochemistry & Molecular Biology

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

Thomas M. Durcan et al.

EMBO JOURNAL (2014)

Article Biochemistry & Molecular Biology

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

Wenxian Wu et al.

EMBO REPORTS (2014)

Article Biochemistry & Molecular Biology

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

Tom Cornelissen et al.

HUMAN MOLECULAR GENETICS (2014)

Article Cell Biology

Mutations in Fis1 disrupt orderly disposal of defective mitochondria

Qinfang Shen et al.

MOLECULAR BIOLOGY OF THE CELL (2014)

Article Biochemistry & Molecular Biology

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12-5-16L1

Hannah C. Dooley et al.

MOLECULAR CELL (2014)

Article Multidisciplinary Sciences

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

Baris Bingol et al.

NATURE (2014)

Article Multidisciplinary Sciences

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

Yvette C. Wong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Genetics & Heredity

Functions of SAGA in development and disease

Li Wang et al.

EPIGENOMICS (2014)

Article Multidisciplinary Sciences

A dual role for autophagy in a murine model of lung cancer

Shuan Rao et al.

NATURE COMMUNICATIONS (2014)

Editorial Material Cell Biology

Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation

Marta Walczak et al.

AUTOPHAGY (2013)

Review Cell Biology

The ULK1 complex Sensing nutrient signals for autophagy activation

Pui-Mun Wong et al.

AUTOPHAGY (2013)

Article Biochemistry & Molecular Biology

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein

Chris Froehlich et al.

EMBO JOURNAL (2013)

Article Biochemistry & Molecular Biology

Structure of the human ATG12∼ATG5 conjugate required for LC3 lipidation in autophagy

Chinatsu Otomo et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12

Zoltan Metlagel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

Emerging roles of E3 ubiquitin ligases in autophagy

Ersheng Kuang et al.

TRENDS IN BIOCHEMICAL SCIENCES (2013)

Review Oncology

Ubiquitin at the crossroad of cell death and survival

Yu-Shan Chen et al.

CHINESE JOURNAL OF CANCER (2013)

Article Biochemistry & Molecular Biology

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

Harald W. Platta et al.

BIOCHEMICAL JOURNAL (2012)

Article Biochemistry & Molecular Biology

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

Andrew W. Greene et al.

EMBO REPORTS (2012)

Review Biotechnology & Applied Microbiology

Therapeutic targets in cancer cell metabolism and autophagy

Heesun Cheong et al.

NATURE BIOTECHNOLOGY (2012)

Article Multidisciplinary Sciences

BNIP3 and NIX Mediate Mieap-Induced Accumulation of Lysosomal Proteins within Mitochondria

Yasuyuki Nakamura et al.

PLOS ONE (2012)

Review Oncology

Deconvoluting the context-dependent role for autophagy in cancer

Eileen White

NATURE REVIEWS CANCER (2012)

Article Cardiac & Cardiovascular Systems

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

Youngil Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)

Review Biochemistry & Molecular Biology

The Interplay Between Mitochondrial Dynamics and Mitophagy

Gilad Twig et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

Article Biochemistry & Molecular Biology

The Multifaceted Roles of USP7: New Therapeutic Opportunities

Benjamin Nicholson et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2011)

Review Biochemistry & Molecular Biology

The Beclin 1 network regulates autophagy and apoptosis

R. Kang et al.

CELL DEATH AND DIFFERENTIATION (2011)

Article Cell Biology

Autophagy-deficient mice develop multiple liver tumors

Akito Takamura et al.

GENES & DEVELOPMENT (2011)

Article Biochemistry & Molecular Biology

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

Liliane Glauser et al.

JOURNAL OF NEUROCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis

Assaf D. Rubinstein et al.

MOLECULAR CELL (2011)

Article Biochemistry & Molecular Biology

Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7

Nobuo N. Noda et al.

MOLECULAR CELL (2011)

Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

Review Biotechnology & Applied Microbiology

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

Lynn Bedford et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Biochemistry & Molecular Biology

Constructing and decoding unconventional ubiquitin chains

Christian Behrends et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Multidisciplinary Sciences

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

Libin Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Cardiac & Cardiovascular Systems

Stressing the ubiquitin-proteasome system

Nico P. Dantuma et al.

CARDIOVASCULAR RESEARCH (2010)

Article Biochemistry & Molecular Biology

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

Joo-Yong Lee et al.

EMBO JOURNAL (2010)

Review Biochemistry & Molecular Biology

Autophagy and the Integrated Stress Response

Guido Kroemer et al.

MOLECULAR CELL (2010)

Review Cell Biology

Autophagy in mammalian development and differentiation

Noboru Mizushima et al.

NATURE CELL BIOLOGY (2010)

Article Cell Biology

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler et al.

NATURE CELL BIOLOGY (2010)

Article Multidisciplinary Sciences

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Cristofol Vives-Bauza et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

TRAF6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy

Chong-Shan Shi et al.

SCIENCE SIGNALING (2010)

Article Cell Biology

Atg101, a novel mammalian autophagy protein interacting with Atg13

Nao Hosokawa et al.

AUTOPHAGY (2009)

Article Biochemistry & Molecular Biology

Autophagy Suppresses Tumorigenesis through Elimination of p62

Robin Mathew et al.

Article Cell Biology

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Chang Hwa Jung et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Review Cell Biology

Autophagy-physiology and pathophysiology

Yasuo Uchiyama et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function

Keisuke Obara et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Review Multidisciplinary Sciences

Autophagy fights disease through cellular self-digestion

Noboru Mizushima et al.

NATURE (2008)

Article Multidisciplinary Sciences

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

Yufeng Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy

Takao Hanada et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Cell Biology

Autophagy: process and function

Noboru Mizushima

GENES & DEVELOPMENT (2007)

Review Cell Biology

Autophagosome formation: Core machinery and adaptations

Zhiping Xie et al.

NATURE CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Serhiy Pankiv et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Cell Biology

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

Chengyu Liang et al.

NATURE CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules

Lidia M. Duncan et al.

EMBO JOURNAL (2006)

Review Biochemistry & Molecular Biology

The pleiotropic role of autophagy: from protein metabolism to bactericide

N Mizushima

CELL DEATH AND DIFFERENTIATION (2005)

Article Immunology

The diversity expression of p62 in digestive system cancers

YX Su et al.

CLINICAL IMMUNOLOGY (2005)

Article Biochemistry & Molecular Biology

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

JJ Lum et al.

Review Oncology

The proteasome: A suitable antineoplastic target

J Adams

NATURE REVIEWS CANCER (2004)

Review Cell Biology

Death by design: apoptosis, necrosis and autophagy

AL Edinger et al.

CURRENT OPINION IN CELL BIOLOGY (2004)

Article Multidisciplinary Sciences

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

ZY Yue et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

U Schubert et al.

NATURE (2000)