Molecular Tailored Therapeutic Options for Advanced Gastrointestinal Stromal Tumors (GISTs): Current Practice and Future Perspectives

Gastrointestinal stromal tumors (GISTs) are one of the most common mesenchymal tumors characterized by different molecular alterations that lead to specific clinical presentations and behaviors. In the last twenty years, thanks to the discovery of these mutations, several new treatment options have emerged. This review provides an extensive overview of GISTs' molecular pathways and their respective tailored therapeutic strategies. Furthermore, current treatment strategies under investigation and future perspectives are analyzed and discussed.

Automated summary

Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors characterized by specific clinical presentations and behaviors due to molecular alterations. In the past twenty years, the discovery of these mutations has led to the emergence of new treatment options. This review provides a comprehensive overview of the molecular pathways and tailored therapeutic strategies for GISTs. Additionally, current treatment strategies under investigation and future perspectives are analyzed and discussed.