4.6 Article

CDK4/6 Inhibition Induces Senescence and Enhances Radiation Response by Disabling DNA Damage Repair in Oral Cavity Squamous Cell Carcinoma

Related references

Note: Only part of the references are listed.
Article Virology

Establishment of a diverse head and neck squamous cancer cell bank using conditional reprogramming culture methods

Daniel Li et al.

Summary: By using the conditional reprogramming (CR) method, we established a robust panel of HNSCC tumor cell lines from ethnically and racially diverse patients in the Bronx. These cell lines expressed markers of squamous identity and were able to form three-dimensional spheroids and murine models.

JOURNAL OF MEDICAL VIROLOGY (2023)

Article Medicine, General & Internal

Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma

Tong-Hong Wang et al.

Summary: The study revealed that palbociclib effectively inhibited the growth, migration, and invasion ability of OSCC cells while promoting cellular senescence and apoptosis. It was found that palbociclib induced DNA damage and p21 expression through the p53 independent pathway, leading to the downregulation of c-Myc and CDC25A expression to inhibit cell cycle progression. Additionally, palbociclib downregulated RAD51 expression to impede the DNA damage repair capability of OSCC cells.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2021)

Article Oncology

Palbociclib Renders Human Papilloma Virus-Negative Head and Neck Squamous Cell Carcinoma Vulnerable to the Senolytic Agent Navitoclax

Nicholas J. Gadsden et al.

Summary: Inhibition of CDK4/6 leads to senescence in HPV- HNSCC, which can be effectively eliminated by combining palbociclib and navitoclax. This combination therapy decreases cell survival and increases apoptosis levels in HPV- HNSCC cell lines.

MOLECULAR CANCER RESEARCH (2021)

Article Oncology

Prognostic Genetic Biomarkers Based on Oncogenic Signaling Pathways for Outcome Prediction in Patients with Oral Cavity Squamous Cell Carcinoma

Wen-Lang Fan et al.

Summary: By analyzing mutational signatures and oncogenic signaling pathways in whole exome-sequencing data, a specific subgroup of patients with a significantly negative impact on disease-free and overall survival in OCSCC was identified, revealing potential target genes. The study showed that multiple genes drive the development of oral cavity squamous cell carcinoma in multiple pathways and identified candidate genes and pathways that may serve as prognostic genetic biomarkers or therapeutic targets.

CANCERS (2021)

Review Biology

Cellular senescence: from anti-cancer weapon to anti-aging target

Lifeng Yuan et al.

SCIENCE CHINA-LIFE SCIENCES (2020)

Review Otorhinolaryngology

CDK4/6 inhibitors in P16/HPV16-negative squamous cell carcinoma of the head and neck

Camelia Billard-Sandu et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2020)

Article Oncology

Inhibition of CDK4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas

Eva-Leonne Gottgens et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2019)

Review Cell Biology

Hallmarks of Cellular Senescence

Alejandra Hernandez-Segura et al.

TRENDS IN CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity

Bruna R. S. Correa et al.

SCIENTIFIC REPORTS (2018)

Review Cell Biology

CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest

Shom Goel et al.

TRENDS IN CELL BIOLOGY (2018)

Review Oncology

Organoids in cancer research

Jarno Drost et al.

NATURE REVIEWS CANCER (2018)

Article Oncology

The safety and efficacy of palbociclib in the treatment of metastatic breast cancer

Johannes Ettl et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2017)

Review Oncology

Targeting CDK4 and CDK6: From Discovery to Therapy

Charles J. Sherr et al.

CANCER DISCOVERY (2016)

Article Medicine, General & Internal

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

R. L. Ferris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Multidisciplinary Sciences

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

Reut Yosef et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Comprehensive genomic characterization of head and neck squamous cell carcinomas

Michael S. Lawrence et al.

NATURE (2015)

Article Cell Biology

Repair of Strand Breaks by Homologous Recombination

Maria Jasin et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Multidisciplinary Sciences

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Nicolas Stransky et al.

SCIENCE (2011)

Review Oncology

The molecular biology of head and neck cancer

C. Rene Leemans et al.

NATURE REVIEWS CANCER (2011)

Review Oncology

Therapy-Induced Senescence in Cancer

Jonathan A. Ewald et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)

Review Oncology

HPV-associated head and neck cancer: a virus-related cancer epidemic

Shanthi Marur et al.

LANCET ONCOLOGY (2010)

Review Virology

The human papillomavirus E7 oncoprotein

Margaret E. McLaughlin-Drubin et al.

VIROLOGY (2009)

Review Cell Biology

Cellular senescence: when bad things happen to good cells

Judith Campisi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Biochemical Research Methods

Clonogenic assay of cells in vitro

Nicolaas A. P. Franken et al.

NATURE PROTOCOLS (2006)

Review Oncology

State-of-the-art management of locally advanced head and neck cancer

TY Seiwert et al.

BRITISH JOURNAL OF CANCER (2005)

Article Oncology

Timeline - Radiation oncology: a century of achievements

J Bernier et al.

NATURE REVIEWS CANCER (2004)

Review Oncology

Role of cell cycle in mediating sensitivity to radiotherapy

TM Pawlik et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2004)

Article Medicine, General & Internal

Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer

J Bernier et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Medicine, General & Internal

Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck

JS Cooper et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Medicine, General & Internal

Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer

AA Forastiere et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Review Biochemistry & Molecular Biology

Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

K Münger et al.

ONCOGENE (2001)