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miR-221/222 sponge abrogates tamoxifen resistance in ER-positive breast cancer cells through restoring the expression of ERα

Yan Xiu Ouyang et al.

Summary: The study focused on reversing tamoxifen resistance in breast cancer by targeting miR-221 and miR-222 with synthetic sponges. Through restoring the expression of ER alpha and PTEN, the sponge successfully restored cell responsiveness to tamoxifen and arrested cell growth and migration in G1 phase.

MOLECULAR BIOMEDICINE (2021)

Review Medical Laboratory Technology

Diagnostic Role of Long Non-Coding RNAs in Breast Cancer: a Systematic Review and Meta-Analysis

Xiaojiao Gao et al.

Summary: This meta-analysis revealed that lncRNAs testing has a high accuracy in diagnosing breast cancer, demonstrating significant clinical value in diagnosis.

CLINICAL LABORATORY (2021)

Article Oncology

Design and Functional Validation of a Mutant Variant o f the LncRNA HOTAIR to Counteract Snail Function in Epithelial-to-Mesenchymal Transition

Cecilia Battistelli et al.

Summary: The study introduced a mutant form of HOTAIR called HOTAIR-sbid, which can disrupt the function of HOTAIR in regulating specific epithelial target genes, affecting the EMT process and reducing the invasiveness and motility of tumor cells.

CANCER RESEARCH (2021)

Article Oncology

Circular RNA circTP63 enhances estrogen receptor-positive breast cancer progression and malignant behaviors through the miR-873-3p/FOXM1 axis

Yibin Deng et al.

Summary: The study found that circTP63 binds to miR-873-3p, inhibiting the expression of FOXM1, thus inducing malignant behaviors in estrogen receptor-positive breast cancer. CircTP63 may serve as a potential biomarker or target for treating patients with estrogen receptor-positive breast cancer in the future.

ANTI-CANCER DRUGS (2021)

Review Genetics & Heredity

Regulation of gene expression by cis-acting long non-coding RNAs

Noa Gil et al.

NATURE REVIEWS GENETICS (2020)

Review Cell Biology

The double dealing of cyclin D1

Guergana Tchakarska et al.

CELL CYCLE (2020)

Article Biochemistry & Molecular Biology

Structure-Mediated RNA Decay by UPF1 and G3BP1

Joseph W. Fischer et al.

MOLECULAR CELL (2020)

Article Biochemistry & Molecular Biology

Identification of miRNAs Enriched in Extracellular Vesicles Derived from Serum Samples of Breast Cancer Patients

Patricia M. M. Ozawa et al.

BIOMOLECULES (2020)

Article Oncology

FOXO1 as a tumor suppressor inactivated via AR/ERβ signals in urothelial cells

Hiroki Ide et al.

ENDOCRINE-RELATED CANCER (2020)

Review Oncology

Pharmacogenomics of breast cancer: highlighting CYP2D6 and tamoxifen

Carmen W. H. Chan et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2020)

Editorial Material Cell Biology

Structure-Mediated Degradation of CircRNAs

Yingli Guo et al.

TRENDS IN CELL BIOLOGY (2020)

Article Biotechnology & Applied Microbiology

Determination of Serum Exosomal H19 as a Noninvasive Biomarker for Breast Cancer Diagnosis

Guobin Zhong et al.

ONCOTARGETS AND THERAPY (2020)

Review Medicine, Research & Experimental

The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment

Hossein Mozdarani et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

An HMGA2-p62-ERα axis regulates uterine leiomyomas proliferation

Binya Liu et al.

FASEB JOURNAL (2020)

Review Pharmacology & Pharmacy

Long noncoding RNAs in cancer immunity: a new avenue in drug discovery

Anindya Dutta et al.

DRUG DISCOVERY TODAY (2020)

Article Multidisciplinary Sciences

LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer

Qianfeng Shi et al.

NATURE COMMUNICATIONS (2020)

Review Cell Biology

Regulation of microRNA function in animals

Luca F. R. Gebert et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Cell Biology

miR-142-3p is a tumor suppressor that inhibits estrogen receptor expression in ER-positive breast cancer

Behzad Mansoori et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Genetics & Heredity

Circular RNA expression in exosomes derived from breast cancer cells and patients

Jinyan Wang et al.

EPIGENOMICS (2019)

Article Pharmacology & Pharmacy

Evaluating ZNF217 mRNA Expression Levels as a Predictor of Response to Endocrine Therapy in ER plus Breast Cancer

Julie A. Vendrell et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Exosomal circRNAs: biogenesis, effect and application in human diseases

Yangxia Wang et al.

MOLECULAR CANCER (2019)

Article Biochemistry & Molecular Biology

ESR1-Stabilizing Long Noncoding RNA TMPO-AS1 Promotes Hormone-Refractory Breast Cancer Progression

Yuichi Mitobe et al.

MOLECULAR AND CELLULAR BIOLOGY (2019)

Review Endocrinology & Metabolism

Pathways to Endocrine Therapy Resistance in Breast Cancer

Md Moquitul Haque et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Oncology

Resistance to endocrine therapy in breast cancer: molecular mechanisms and future goals

Malgorzata Szostakowska et al.

BREAST CANCER RESEARCH AND TREATMENT (2019)

Article Biochemistry & Molecular Biology

Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis

Liyuan Fan et al.

MOLECULAR CANCER (2019)

Article Multidisciplinary Sciences

The biochemical basis of microRNA targeting efficacy

Sean E. McGeary et al.

SCIENCE (2019)

Review Biochemistry & Molecular Biology

Long Non-Coding RNAs in the Regulation of Gene Expression: Physiology and Disease

Juliane C. R. Fernandes et al.

NON-CODING RNA (2019)

Article Biochemistry & Molecular Biology

exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

Shengli Li et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Biochemistry & Molecular Biology

Functional Classification and Experimental Dissection of Long Noncoding RNAs

Florian Kopp et al.

Review Biochemistry & Molecular Biology

Metazoan MicroRNAs

David P. Bartel

Review Oncology

Non-coding RNAs: long non-coding RNAs and microRNAs in endocrine-related cancers

Carolyn M. Klinge

ENDOCRINE-RELATED CANCER (2018)

Review Cell Biology

Estrogen and progesterone signalling in the normal breast and its implications for cancer development

Heidi N. Hilton et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)

Article Biochemistry & Molecular Biology

Novel tumour suppressive protein encoded by circular RNA, circ-SHPRH, in glioblastomas

S. Begum et al.

ONCOGENE (2018)

Review Biochemical Research Methods

microRNA Regulation in Estrogen Receptor-Positive Breast Cancer and Endocrine Therapy

Erin W. Howard et al.

BIOLOGICAL PROCEDURES ONLINE (2018)

Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Biotechnology & Applied Microbiology

Long noncoding RNA H19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process

Hongli Gao et al.

ONCOTARGETS AND THERAPY (2018)

Article Cell Biology

miR-449a Suppresses Tamoxifen Resistance in Human Breast Cancer Cells by Targeting ADAM22

Jun Li et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

Article Chemistry, Multidisciplinary

MicroRNA-132 suppresses cell proliferation in human breast cancer by directly targeting FOXA1

Dan Wang et al.

ACTA PHARMACOLOGICA SINICA (2018)

Review Oncology

A Review of Physical Activity and Circulating miRNA Expression: Implications in Cancer Risk and Progression

Suzanne Dufresne et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2018)

Article Biochemistry & Molecular Biology

MicroRNA-335-5p and-3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance

Elizabeth C. Martin et al.

FEBS LETTERS (2017)

Article Cell Biology

Identification of miRNAs as biomarkers for acquired endocrine resistance in breast cancer

Penn Muluhngwi et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)

Article Biochemistry & Molecular Biology

Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer

Wan-xin Peng et al.

MOLECULAR CANCER (2017)

Article Oncology

IGF-1 Receptor Modulates FoxO1-Mediated Tamoxifen Response in Breast Cancer Cells

Ali Vaziri-Gohar et al.

MOLECULAR CANCER RESEARCH (2017)

Review Oncology

Cell-to-cell communication: microRNAs as hormones

Recep Bayraktar et al.

MOLECULAR ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

Kotb Abdelmohsen et al.

RNA BIOLOGY (2017)

Review Multidisciplinary Sciences

How do lncRNAs regulate transcription?

Yicheng Long et al.

SCIENCE ADVANCES (2017)

Article Biochemistry & Molecular Biology

LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer

X. Xue et al.

ONCOGENE (2016)

Review Biochemistry & Molecular Biology

RISC assembly: Coordination between small RNAs and Argonaute proteins

Hotaka Kobayashi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2016)

Article Biochemistry & Molecular Biology

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

William W. Du et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Multidisciplinary Sciences

The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression

Yashar S. Niknafs et al.

NATURE COMMUNICATIONS (2016)

Review Genetics & Heredity

Long Non-coding RNAs in the Cytoplasm

Farooq Rashid et al.

GENOMICS PROTEOMICS & BIOINFORMATICS (2016)

Review Medicine, General & Internal

Considering Exosomal miR-21 as a Biomarker for Cancer

Jian Shi

JOURNAL OF CLINICAL MEDICINE (2016)

Review Pharmacology & Pharmacy

MiR 221/222 as New Players in Tamoxifen Resistance

Nafiseh Sadat Alamolhodaei et al.

CURRENT PHARMACEUTICAL DESIGN (2016)

Article Biochemistry & Molecular Biology

A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance

Douglas M. Anderson et al.

Review Biochemistry & Molecular Biology

The Role of MicroRNAs as Predictors of Response to Tamoxifen Treatment in Breast Cancer Patients

Nina G. Egeland et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Review Biochemistry & Molecular Biology

What have we learned about GPER function in physiology and disease from knockout mice?

Eric R. Prossnitz et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells

Zhike Chen et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing

Yao-Yin Chang et al.

MOLECULAR CANCER (2015)

Article Biochemistry & Molecular Biology

Structure of a Biologically Active Estrogen Receptor-Coactivator Complex on DNA

Ping Yi et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs

Myung Hyun Jo et al.

MOLECULAR CELL (2015)

Review Biochemistry & Molecular Biology

Long Non-Coding RNA Regulation of Reproduction and Development

David H. Taylor et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2015)

Review Genetics & Heredity

NON-CODING RNA Towards a molecular understanding of microRNA-mediated gene silencing

Stefanie Jonas et al.

NATURE REVIEWS GENETICS (2015)

Review Cell Biology

The biological functions of miRNAs: lessons from in vivo studies

Joana A. Vidigal et al.

TRENDS IN CELL BIOLOGY (2015)

Article Multidisciplinary Sciences

Rolling Circle Translation of Circular RNA in Living Human Cells

Naoko Abe et al.

SCIENTIFIC REPORTS (2015)

Article Oncology

ENDOCRINE THERAPY IN BREAST CANCER: THE NEOADJUVANT, ADJUVANT, AND METASTATIC APPROACH

Raquel E. Reinbolt et al.

SEMINARS IN ONCOLOGY NURSING (2015)

Article Oncology

Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells

Yifang Wei et al.

BREAST CANCER RESEARCH AND TREATMENT (2014)

Article Oncology

HITS-CLIP reveals key regulators of nuclear receptor signaling in breast cancer

Manoj M. Pillai et al.

BREAST CANCER RESEARCH AND TREATMENT (2014)

Article Biochemistry & Molecular Biology

Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer

Ramesh Singh et al.

MOLECULAR CANCER (2014)

Review Biotechnology & Applied Microbiology

Detecting and characterizing circular RNAs

William R. Jeck et al.

NATURE BIOTECHNOLOGY (2014)

Review Cell Biology

Regulation of microRNA biogenesis

Minju Ha et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Multidisciplinary Sciences

miR-342 Regulates BRCA1 Expression through Modulation of ID4 in Breast Cancer

Elisabetta Crippa et al.

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1

Christopher Rouya et al.

Article Multidisciplinary Sciences

Natural RNA circles function as efficient microRNA sponges

Thomas B. Hansen et al.

NATURE (2013)

Article Multidisciplinary Sciences

Circular RNAs are a large class of animal RNAs with regulatory potency

Sebastian Memczak et al.

NATURE (2013)

Article Medicine, Research & Experimental

miR-342 is associated with estrogen receptor-α expression and response to tamoxifen in breast cancer

Yue-Jun He et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2013)

Article Biotechnology & Applied Microbiology

Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells

Deborah A. Sanders et al.

GENOME BIOLOGY (2013)

Article Multidisciplinary Sciences

Landscape of transcription in human cells

Sarah Djebali et al.

NATURE (2012)

Review Endocrinology & Metabolism

miRNAs and estrogen action

Carolyn M. Klinge

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)

Review Cell Biology

Posttranscriptional Upregulation by MicroRNAs

Shobha Vasudevan

WILEY INTERDISCIPLINARY REVIEWS-RNA (2012)

Article Biochemistry & Molecular Biology

let-7 MicroRNAs Induce Tamoxifen Sensitivity by Downregulation of Estrogen Receptor α Signaling in Breast Cancer

Yingchun Zhao et al.

MOLECULAR MEDICINE (2011)

Article Genetics & Heredity

FOXA1 is a key determinant of estrogen receptor function and endocrine response

Antoni Hurtado et al.

NATURE GENETICS (2011)

Article Oncology

Estrogen Receptor β1 Expression Is Regulated by miR-92 in Breast Cancer

Hakeemah Al-Nakhle et al.

CANCER RESEARCH (2010)

Article Biochemistry & Molecular Biology

MicroRNA: Biogenesis, Function and Role in Cancer

Leigh-Ann MacFarlane et al.

CURRENT GENOMICS (2010)

Article Biochemistry & Molecular Biology

MiR-205 silences MED1 in hypoxic primary human trophoblasts

Jean-Francois Mouillet et al.

FASEB JOURNAL (2010)

Article Biochemistry & Molecular Biology

The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity

Shilpa Chooniedass-Kothari et al.

FEBS LETTERS (2010)

Article Biochemistry & Molecular Biology

Downregulation of miR-342 is associated with tamoxifen resistant breast tumors

Diana M. Cittelly et al.

MOLECULAR CANCER (2010)

Article Multidisciplinary Sciences

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

Ian G. Cannell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Endocrinology & Metabolism

MicroRNAs Link Estrogen Receptor Alpha Status and Dicer Levels in Breast Cancer

Dawn R. Cochrane et al.

Hormones & Cancer (2010)

Article Biochemistry & Molecular Biology

miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor α mRNA

Deo Prakash Pandey et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

The estrogen receptor-α-induced microRNA signature regulates itself and its transcriptional response

Leandro Castellano et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest

Fang Sun et al.

FEBS LETTERS (2008)

Article Biochemistry & Molecular Biology

c-Myc overexpression and endocrine resistance in breast cancer

Catriona M. McNeil et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA

Anwar Hossain et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter

Fabio Stossi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Chemistry, Medicinal

Estrogen receptors as therapeutic targets in breast cancer

Eric A. Ariazi et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2006)

Review Oncology

Mechanisms of tamoxifen resistance

A Ring et al.

ENDOCRINE-RELATED CANCER (2004)

Article Biochemistry & Molecular Biology

SRA coactivation of estrogen receptor-α is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity

KM Coleman et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Biochemistry & Molecular Biology

The aryl hydrocarbon receptor mediates degradation of estrogen receptor α through activation of proteasomes

M Wormke et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Opposing action of estrogen receptors α and β on cyclin D1 gene expression

MM Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)