4.6 Article

DCVax-L Vaccination in Patients with Glioblastoma: Real Promise or Negative Trial? The Debate Is Open

Related references

Note: Only part of the references are listed.
Article Oncology

Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial

Antonio Omuro et al.

Summary: This study showed that TMZ + RT had better efficacy than NIVO + RT in newly diagnosed GBM patients with unmethylated MGMT promoter. However, no new safety signals were detected with NIVO in this study.

NEURO-ONCOLOGY (2023)

Article Oncology

Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma A Phase 3 Prospective Externally Controlled Cohort Trial

Linda M. Liau et al.

Summary: The study shows that adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax L) to standard of care can extend the survival of patients with glioblastoma.

JAMA ONCOLOGY (2023)

Review Medicine, Research & Experimental

Dendritic cell vaccines in breast cancer: Immune modulation and immunotherapy

Da Qian et al.

Summary: Breast cancer is the most common cancer in women worldwide. Immunotherapy, including tumor vaccine, has shown great success in treating breast cancer. Dendritic cells are important antigen-presenting cells that play a role in immune responses. DC-based treatments, particularly DC vaccines, have demonstrated significant anti-tumor effects in clinical studies and are undergoing trials. This review summarizes the immunomodulatory effects of DC vaccines in breast cancer, discusses related mechanisms, and presents possible challenges and future directions.

BIOMEDICINE & PHARMACOTHERAPY (2023)

Editorial Material Oncology

Nonrandomised controlled trial in recurrent glioblastoma patients: the promise of autologous tumour lysate-loaded dendritic cell vaccination

Francesco Pasqualetti et al.

Summary: Liau et al. recently published the findings of a Phase 3 clinical trial evaluating the efficacy of DCVax-L vaccines in patients with glioblastoma. Although the study yielded promising and significant results, some concerns were raised regarding the study design and the lengthy recruitment period.

BRITISH JOURNAL OF CANCER (2023)

Article Clinical Neurology

Autologous tumor lysate-loaded dendritic cell vaccination in glioblastoma: What happened to the evidence?

T. Olivier et al.

Summary: The addition of autologous tumor lysate-loaded denditric cell vaccination to the standard of care improved overall survival in patients with glioblastoma, but did not improve progression-free survival. However, the trial's design and methodology raised concerns about the ability to draw meaningful conclusions.

REVUE NEUROLOGIQUE (2023)

Review Immunology

T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications

Xiaoxia Chi et al.

Summary: In this review, the crucial role of T cells in immune response regulation and their importance in cancer immunotherapy are discussed. The progress in understanding T-cell exhaustion and stemness in cancer immunotherapy is described, along with potential strategies to reverse T-cell exhaustion and maintain T-cell stemness. Therapeutic strategies to overcome T-cell immunodeficiency in the tumor microenvironment and enhance T-cell anticancer activity are also discussed.

FRONTIERS IN IMMUNOLOGY (2023)

Article Medicine, Research & Experimental

Advances in dendritic cell vaccination therapy of cancer

Sajad Najafi et al.

Summary: Traditionally, vaccines have played a crucial role in eradicating infectious diseases and saving millions of lives. However, the development of anticancer vaccines faces challenges and requires further optimization. Dendritic cells, as the most potent antigen presenting cells, have been used in tumor immunotherapies but their efficacy needs improvement.

BIOMEDICINE & PHARMACOTHERAPY (2023)

Review Oncology

External control arms in oncology: current use and future directions

P. S. Mishra-Kalyani et al.

Summary: This paper introduces the concept of external controls in oncology trials and reviews relevant research on this topic. It discusses the use of external control data to expand the interpretability of experimental results when a randomized design is not feasible. The paper also provides general considerations for designing trials that incorporate external control data and presents case studies of marketing applications that included external control data submitted to the Food and Drug Administration.

ANNALS OF ONCOLOGY (2022)

Article Oncology

Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma

Jedd D. Wolchok et al.

Summary: The 6.5-year results of the CheckMate 067 trial demonstrate durable clinical benefits with nivolumab plus ipilimumab or nivolumab monotherapy compared to ipilimumab alone in patients with advanced melanoma.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Oncology

Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter

Michael Lim et al.

Summary: The study evaluated the addition of the immune checkpoint inhibitor nivolumab (NIVO) to radiotherapy (RT) + temozolomide (TMZ) in newly diagnosed glioblastoma patients and found that it did not improve survival in these patients.

NEURO-ONCOLOGY (2022)

Editorial Material Medicine, General & Internal

Reliable, cheap, fast and few: What is the best study for assessing medical practices? Randomized controlled trials or synthetic control arms?

Vinay Prasad

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Multidisciplinary Sciences

A vaccine targeting mutant IDH1 in newly diagnosed glioma

Michael Platten et al.

Summary: Mutated isocitrate dehydrogenase 1 (IDH1) defines a molecularly distinct subtype of diffuse glioma. The most common IDH1 mutation in gliomas affects codon 132 and encodes IDH1(R132H), which harbours a shared clonal neoepitope that is presented on major histocompatibility complex (MHC) class II. An IDH1(R132H)-specific peptide vaccine (IDH1-vac) induces specific therapeutic T helper cell responses that are effective against IDH1(R132H)+ tumours.

NATURE (2021)

Article Clinical Neurology

The Current Landscape of Immune Checkpoint Blockade in Glioblastoma

Oluwatosin O. Akintola et al.

Summary: Immune checkpoint blockade has been successful in managing solid malignancies, but not in glioblastoma treatment. Ongoing studies are evaluating the potential role of immune checkpoint blockade in glioblastoma management. Multimodal immunotherapy for glioblastoma is actively being investigated, with expected results to guide future immunotherapy approaches.

NEUROSURGERY CLINICS OF NORTH AMERICA (2021)

Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

The CNS and the Brain Tumor Microenvironment: Implications for Glioblastoma Immunotherapy

Fiona A. Desland et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Immunology

Mechanisms of immunotherapy resistance: lessons from glioblastoma

Christopher M. Jackson et al.

NATURE IMMUNOLOGY (2019)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer

M. D. Hellmann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Biochemistry & Molecular Biology

PD-L1/PD-1 Axis in Glioblastoma Multiforme

Jakub Litak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, Research & Experimental

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Linda M. Liau et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

Article Medicine, General & Internal

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

R. J. Motzer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

P. Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Oncology

Tumour-associated macrophages as treatment targets in oncology

Alberto Mantovani et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Medicine, General & Internal

Lomustine and Bevacizumab in Progressive Glioblastoma

Wolfgang Wick et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

R. L. Ferris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Multidisciplinary Sciences

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Nicholas McGranahan et al.

SCIENCE (2016)

Review Multidisciplinary Sciences

T cell exclusion, immune privilege, and the tumor microenvironment

Johanna A. Joyce et al.

SCIENCE (2015)

Review Immunology

Overcoming T cell exhaustion in infection and cancer

Kristen E. Pauken et al.

TRENDS IN IMMUNOLOGY (2015)

Article Medicine, General & Internal

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

Mark R. Gilbert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Biotechnology & Applied Microbiology

DCVax®-L-Developed by Northwest Biotherapeutics

Stavros Polyzoidis et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

Article Oncology

Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial

Mark R. Gilbert et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

Article Oncology

Scale to Predict Survival After Surgery for Recurrent Glioblastoma Multiforme

John K. Park et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

Article Medicine, General & Internal

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

R Stupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Gastroenterology & Hepatology

Antitumor effects of vaccine consisting of dendritic cells pulsed with tumor RNA from gastric cancer

Bing-Ya Liu et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2004)