Journal
JOURNAL OF CLINICAL MEDICINE
Volume 12, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/jcm12134179
Keywords
psoriasis; systemic treatment; biologic treatment; immune checkpoint
Categories
Ask authors/readers for more resources
The PD-1 receptor and its ligands, PD-L1 and PD-L2, are involved in immune tolerance and prevention of immune-mediated diseases. This study found lower levels of PD-1 and PD-L1 expression in psoriatic patients compared to healthy individuals. Biologic therapy increased PD-L1 expression and decreased PD-1 expression. The disruption of the PD-1/PD-L1 pathway in psoriasis suggests its importance in disease development, and biologic drugs may reverse these abnormalities.
The programmed death-1 (PD-1) receptor plays a major physiological role in the maintenance of immune tolerance and, by interaction with its ligands (PD-L1 and PD-L2), prevents the development of multiple immune-mediated diseases. There is growing evidence of the PD-1/PD-L1 pathway playing an important role in the pathogenesis of psoriasis. In total, 84 subjects with psoriasis were included in this study, together with 29 healthy subjects as a control group. Twenty-eight of the psoriatic patients were treated with biologic therapy (TNF-alpha, interleukin (IL)-12/23, or IL-17 inhibitors). The amounts of PD-1- and PD-L1-positive T-cells in peripheral blood were evaluated using flow cytometry. Significantly lower levels of peripheral blood mononuclear cells (PBMCs) with the expression of PD-1 and PD-L1 were found in psoriatic patients compared to healthy individuals, i.e., CD3/PD-1-, CD3/PD-L1-, CD4/PD-1-, CD4/PD-L1-, CD8/PD-L1-, CD19/PD-1-, and CD19/PD-L1-positive cells. Biologic treatment resulted in the elevation of CD3/PD-L1- and CD8/PD-L1- and a decrease in CD8/PD-1-positive PBMCs. Our results confirm previous observations of the PD-1/PD-L1 pathway being disrupted in psoriasis, and that these disturbances may play an important role in development of the disease. Biologic drugs may reverse several abnormalities observed within this pathway, which may explain their excellent efficacy in the treatment of psoriasis. Further research should be conducted to fully explain the results obtained.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available