4.7 Review

Molecular Signatures in Ductal Carcinoma In Situ (DCIS): A Systematic Review and Meta-Analysis

Related references

Note: Only part of the references are listed.
Article Genetics & Heredity

Genomic analysis defines clonal relationships of ductal carcinoma in situ and recurrent invasive breast cancer

Esther H. Lips et al.

Summary: A genomic analysis of ductal carcinoma in situ (DCIS) samples reveals that a significant portion of invasive breast cancer recurrences are unrelated to the initial DCIS and have distinct clonal origins. This finding is crucial for accurately assessing the risk of DCIS, developing effective treatment strategies, and identifying predictive biomarkers.

NATURE GENETICS (2022)

Article Oncology

Risk Assessment in the Molecular Era

Christin A. Knowlton et al.

Summary: Ductal carcinoma in situ (DCIS) is commonly treated with breast-conserving surgery (BCS) and radiotherapy (RT). Clinical-pathologic features have traditionally been used to select low-risk DCIS patients who may omit postoperative RT. However, genomic molecular assays offer the potential for personalized risk assessment in combination with existing clinical-pathologic features.

SEMINARS IN RADIATION ONCOLOGY (2022)

Review Oncology

Adjuvant hypofractionated radiotherapy with simultaneous integrated boost after breast-conserving surgery: A systematic literature review

Martin Schmitt et al.

Summary: Several studies have shown that simultaneous integrated boost provides better dose homogeneity, improves the biologically effective dose-volume histogram and reduces treatment time compared to sequential boost in breast cancer.

TRANSLATIONAL ONCOLOGY (2022)

Review Oncology

Prediction Models and Decision Aids for Women with Ductal Carcinoma In Situ: A Systematic Literature Review

Renee S. J. M. Schmitz et al.

Summary: The quality and clinical utility of decision support tools for ductal carcinoma in situ (DCIS) are still in need of improvement. Most existing tools lack features to facilitate discussion with healthcare providers and lack high-quality validation studies. Therefore, there is a need for well-validated decision support tools to meet the treatment needs of DCIS.

CANCERS (2022)

Article Oncology

The Senologic International Society Survey on Ductal Carcinoma In Situ: Present and Future

Carole Mathelin et al.

Summary: This study investigated the management of ductal carcinoma in situ (DCIS) in different countries and found both consensual practices and controversial topics. Further research and clinical trials are needed to reach a consensus on these issues, and personalized treatments are encouraged to avoid overtreatment and overdiagnosis.

EUROPEAN JOURNAL OF BREAST HEALTH (2022)

Article Oncology

Cost-Effectiveness Analysis of Biological Signature DCISionRT Use for DCIS Treatment

Hayeon Kim et al.

Summary: The cost-effectiveness analysis comparing DCIS treatments using DCISionRT testing versus traditional clinicopathologic risk factors showed that DCISionRT testing can increase omission of radiotherapy in low-risk patients and improve cost-effectiveness for radiotherapy in high-risk patients by accurately predicting recurrence risk.

CLINICAL BREAST CANCER (2021)

Article Pathology

Diagnosis of ductal carcinoma in situ in an era of de-escalation of therapy

Stuart J. Schnitt

Summary: The article reviews the epidemiology, natural history, and current treatment options for DCIS and discusses ongoing efforts to de-escalate treatment for these patients.

MODERN PATHOLOGY (2021)

Article Oncology

21-Gene Assay and Breast Cancer Mortality in Ductal Carcinoma In Situ

Eileen Rakovitch et al.

Summary: The 21-gene recurrence score can predict breast cancer mortality in individuals with DCIS, and when combined with age (50 years or younger), it can identify individuals who may benefit from radiotherapy.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Article Oncology

The Clinical Utility of DCISionRT(R) on Radiation Therapy Decision Making in Patients with Ductal Carcinoma In Situ Following Breast-Conserving Surgery

Chirag Shah et al.

Summary: The DCISionRT testing significantly impacted clinicians' recommendations for adjuvant radiation therapy in DCIS patients, leading to changes in the recommended treatment for a significant percentage of patients. The DCISionRT score risk group had the strongest association with radiation therapy recommendations, with other factors such as patient preference, tumor size, and grade also playing a role in decision-making.

ANNALS OF SURGICAL ONCOLOGY (2021)

Article Oncology

Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804

Beryl McCormick et al.

Summary: NRG/RTOG 9804 is the only randomized trial assessing the impact of whole breast irradiation versus observation in women with good-risk ductal carcinoma in situ (DCIS) following lumpectomy. The study found that whole breast irradiation significantly reduced the risk of ipsilateral breast recurrence for DCIS with durable effects at 15 years.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Review Pathology

Molecular Testing in Breast Cancer Current Status and Future Directions

Lulu Sun et al.

Summary: This article provides an overview of the currently available molecular assays for breast cancer, discussing their prognostic, predictive, and therapeutic value. It also covers the detection methods for PIK3CA mutations, NTRK fusions, immune checkpoint inhibitors, as well as the potential utility of next-generation sequencing panels and circulating tumor DNA assays.

JOURNAL OF MOLECULAR DIAGNOSTICS (2021)

Article Oncology

A Comparison of Predicted Ipsilateral Tumor Recurrence Risks in Patients With Ductal Carcinoma in Situ of the Breast After Breast-Conserving Surgery by Breast Radiation Oncologists, the Van Nuys Prognostic Index, the Memorial Sloan Kettering Cancer Center DCIS Nomogram, and the 12-Gene DCIS Score Assay

Rachel Y. Lei et al.

Summary: This study compares ipsilateral breast event (IBE) risks estimated by different tools and radiation oncologists in patients with DCIS post-lumpectomy. The results show significant variations in IBE risk estimates among different tools and radiation oncologists, which may impact clinical decision-making for DCIS cases.

ADVANCES IN RADIATION ONCOLOGY (2021)

Review Radiology, Nuclear Medicine & Medical Imaging

Role of Breast MRI in the Evaluation and Detection of DCIS: Opportunities and Challenges

Heather I. Greenwood et al.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2020)

Article Oncology

Cancer Outcomes in DCIS Patients Without Locoregional Treatment

Marc D. Ryser et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2019)

Meeting Abstract Oncology

The international collaboration of active surveillance trials for low-risk DCIS (LORIS, LORD, COMET, LORETTA).

Chizuko Kanbayashi et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Article Oncology

Breast cancer statistics, 2019

Carol E. DeSantis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Article Oncology

Mortality After Invasive Second Breast Cancers Following Prior Radiotherapy for DCIS

Puyao C. Li et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2019)

Article Genetics & Heredity

BRCA1/BRCA2 mutations in Japanese women with ductal carcinoma in situ

Yan Liu et al.

MOLECULAR GENETICS & GENOMIC MEDICINE (2019)

Article Oncology

Multigene Expression Assay and Benefit of Radiotherapy After Breast Conservation in Ductal Carcinoma in Situ

Eileen Rakovitch et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Oncology

Multigene Expression Assay and Benefit of Radiotherapy After Breast Conservation in Ductal Carcinoma in Situ

Eileen Rakovitch et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Oncology

Cancer statistics: Breast cancer in situ

Elizabeth M. Ward et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2015)

Article Oncology

Addressing overtreatment of screen detected DCIS; the LORIS trial

Adele Francis et al.

EUROPEAN JOURNAL OF CANCER (2015)

Article Oncology

Breast Cancer Mortality After a Diagnosis of Ductal Carcinoma In Situ

Steven A. Narod et al.

JAMA ONCOLOGY (2015)

Article Oncology

A Multigene Expression Assay to Predict Local Recurrence Risk for Ductal Carcinoma In Situ of the Breast

Lawrence J. Solin et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Article Oncology

Ductal Carcinoma in Situ—The Influence of the Radiotherapy Boost on Local Control

Philip Wong et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2011)

Article Computer Science, Interdisciplinary Applications

Conducting Meta-Analyses in R with the metafor Package

Wolfgang Viechtbauer

JOURNAL OF STATISTICAL SOFTWARE (2010)

Article Oncology

Ductal Carcinoma In Situ of the Breast: A Systematic Review of Incidence, Treatment, and Outcomes

Beth A. Virnig et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)

Review Medicine, General & Internal

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

David Moher et al.

PLOS MEDICINE (2009)

Article Oncology

Ductal carcinoma in situ in BRCA mutation carriers

E. Shelley Hwang et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

Article Radiology, Nuclear Medicine & Medical Imaging

Paget's disease of the breast:: Clinical, mammographic, sonographic and pathologic findings in 52 cases

Isil Guenhan-Bilgen et al.

EUROPEAN JOURNAL OF RADIOLOGY (2006)

Review Oncology

The natural history of ductal carcinoma in situ of the breast:: a review

B Erbas et al.

BREAST CANCER RESEARCH AND TREATMENT (2006)

Article Radiology, Nuclear Medicine & Medical Imaging

Mammography of ductal carcinoma in situ of the breast:: Review of 909 cases with radiographic-pathologic correlations

A Barreau et al.

EUROPEAN JOURNAL OF RADIOLOGY (2005)