4.7 Article

Treatment of COVID-19 during the Acute Phase in Hospitalized Patients Decreases Post-Acute Sequelae of COVID-19

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

Prediction value of soluble urokinase plasminogen activator receptor (suPAR) in COVID-19 patients – a systematic review and meta-analysis

Michal Matuszewski et al.

ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE (2023)

Article Medicine, General & Internal

Molnupiravir and risk of post-acute sequelae of covid-19: cohort study

Yan Xie et al.

Summary: The objective of this study was to determine if treatment with the antiviral agent molnupiravir in the first five days of SARS-CoV-2 infection is associated with a reduced risk of post-acute adverse health outcomes. The results showed that compared to no treatment, the use of molnupiravir within five days of a positive SARS-CoV-2 test result was associated with a reduced risk of post-acute COVID-19-related sequelae.

BMJ-BRITISH MEDICAL JOURNAL (2023)

Article Biotechnology & Applied Microbiology

Covid-19 vaccines elicit effective IgG responses in an elderly thymus cancer patient with chemotherapy

Akos Koller et al.

Summary: This article discusses the impact of immunosuppressive chemotherapy on the effectiveness of COVID-19 vaccines and provides a clinical case that demonstrates the achievement of an effective immune response through a series of COVID-19 vaccinations even in an elderly cancer patient.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2023)

Article Biotechnology & Applied Microbiology

COVID-19 vaccine uptake, reasons, and associated factors among older adults in Shenzhen, China

Pei Xie et al.

Summary: This study investigated the uptake and reasons for COVID-19 vaccine among older adults in Shenzhen, China. The results showed that the vaccination rate was lower among adults aged 80 and above and those with chronic diseases. The main reasons for not being vaccinated included doctors not recommending it, being unprepared, and failure to make an appointment. Education, health status, and pneumonia vaccination history were important factors influencing vaccine uptake among older adults.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2023)

Article Medicine, General & Internal

Association of Treatment With Nirmatrelvir and the Risk of Post-COVID-19 Condition

Yan Xie et al.

Summary: This cohort study found that treatment with nirmatrelvir within 5 days of a positive SARS-CoV-2 test result was associated with reduced risk of post-COVID-19 condition (PCC) in individuals with SARS-CoV-2 infection who had at least 1 risk factor for progression to severe disease.

JAMA INTERNAL MEDICINE (2023)

Review Medicine, General & Internal

Risk Factors Associated With Post-COVID-19 Condition A Systematic Review and Meta-analysis

Vasiliki Tsampasian et al.

Summary: Post-COVID-19 condition (PCC) is a complex disorder that has affected millions of people globally. Identifying potential risk factors to understand who is at risk of developing PCC is important for early clinical support.

JAMA INTERNAL MEDICINE (2023)

Article Medicine, General & Internal

Comparability of control and comparison groups in studies assessing long COVID

Alyson Haslam et al.

AMERICAN JOURNAL OF MEDICINE (2023)

Review Medicine, General & Internal

Systematic review with meta-analysis of mid-regional pro-adrenomedullin (MR-proadm) as a prognostic marker in Covid-19-hospitalized patients

Bartosz Fialek et al.

Summary: A comprehensive literature search found a correlation between MR-proADM levels and mortality in COVID-19 patients. The use of MR-proADM may aid in risk stratification, evaluating potential therapy escalation, predicting complications or clinical deterioration, and avoiding unnecessary hospital admissions.

ANNALS OF MEDICINE (2023)

Editorial Material Medicine, General & Internal

Toward a Universal Definition of Post-COVID-19 Condition-How Do We Proceed?

Daniel Pan et al.

JAMA NETWORK OPEN (2023)

Article Medicine, General & Internal

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19

Jennifer Hammond et al.

Summary: In high-risk, unvaccinated adults, treatment of Covid-19 with nirmatrelvir plus ritonavir can significantly reduce the risk of hospitalization and death, with good safety profile.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Multidisciplinary Sciences

Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome

Carlo Cervia et al.

Summary: By studying the immunoglobulin signature of COVID-19 patients and combining it with factors such as age, history of asthma, and symptoms during the primary infection, the risk of post-acute COVID-19 syndrome (PACS) can be predicted independently of the timepoint of blood sampling.

NATURE COMMUNICATIONS (2022)

Review Microbiology

Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms

Qing Han et al.

Summary: Emerging evidence suggests that COVID-19 survivors may experience persistent symptoms for at least 12 months, including fatigue, dyspnea, arthromyalgia, depression, anxiety, memory loss, concentration difficulties, and insomnia. Female patients and those with more severe initial illness are more likely to suffer from long-term sequelae after one year.

PATHOGENS (2022)

Article Immunology

Persistent Symptoms in Adult Patients 1 Year After Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study

Jessica Seessle et al.

Summary: Long COVID, defined as persistent symptoms after SARS-CoV-2 infection, can last for at least 1 year and significantly impact life quality. Neurocognitive symptoms, possibly related to autoimmunity indicated by elevated ANA titers, are more common in females and can persist even when SARS-CoV-2 antibody levels are not significantly different from patients without symptoms.

CLINICAL INFECTIOUS DISEASES (2022)

Article Critical Care Medicine

Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study

Lixue Huang et al.

Summary: With the ongoing COVID-19 pandemic, a study was conducted to characterize the longitudinal evolution of health outcomes in hospitalized survivors of COVID-19 over a period of 2 years. The study found that although most survivors recovered and returned to work within 2 years, a significant proportion of them experienced persistent symptoms and health problems. These findings emphasize the need for further research and interventions to understand and reduce the risk of long-term COVID-19.

LANCET RESPIRATORY MEDICINE (2022)

Review Medicine, General & Internal

Prediction Value of KREBS Von Den Lungen-6 (KL-6) Biomarker in COVID-19 Patients: A Systematic Review and Meta-Analysis

Michal Matuszewski et al.

Summary: The study indicates a significant association between KL-6 levels and COVID-19 infection and severity, with patients having higher KL-6 levels being more likely to develop severe disease.

JOURNAL OF CLINICAL MEDICINE (2022)

Article Biochemistry & Molecular Biology

Monoclonal Antibodies and Antivirals against SARS-CoV-2 Reduce the Risk of Long COVID: A Retrospective Propensity Score-Matched Case-Control Study

Antonio Cimellaro et al.

Summary: This study investigated the occurrence of long COVID in patients receiving early therapy with monoclonal antibodies or antivirals. It found that age, gender, and having at least three comorbidities were directly associated with long COVID, while vaccination and the use of mAbs/antivirals were independently associated with a reduced risk of long COVID.

BIOMEDICINES (2022)

Review Medicine, Research & Experimental

Potential therapeutic options for COVID-19: an update on current evidence

Zahra Niknam et al.

Summary: COVID-19, caused by the novel coronavirus SARS-CoV-2, has become a major public health concern globally. Effective treatments, such as antivirals, anti-inflammatories, respiratory therapy, and antibody therapies, are being used to manage the disease, although no specific treatment has been developed. Ongoing trials are exploring various therapeutic options to assess their efficacy and safety for COVID-19 treatment.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2022)

Letter Medicine, General & Internal

EOSINOPENIA: an early, effective and relevant COVID-19 biomarker?

E. Roca et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Eosinopenia is a reliable marker of severe disease and unfavourable outcome in patients with COVID-19 pneumonia

Massimo Cazzaniga et al.

Summary: This study found that absolute eosinopenia is associated with unfavorable clinical outcomes in patients with COVID-19 pneumonia, suggesting it may be used as a marker for poor prognosis. Patients with absolute eosinopenia were more likely to require intensive respiratory support, had a higher mortality rate, and a lower rate of hospital discharge compared to those without eosinopenia.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Six-month Follow-up Chest CT Findings after Severe COVID-19 Pneumonia

Xiaoyu Han et al.

Summary: The study found that over one-third of severe COVID-19 patients showed fibrotic-like changes in the lung at 6-month follow-up CT, which were associated with older age, acute respiratory distress syndrome, longer hospital stays, tachycardia, noninvasive mechanical ventilation, and higher initial chest CT score.

RADIOLOGY (2021)

Review Immunology

Coronavirus disease 2019 (COVID-19): An overview of the immunopathology, serological diagnosis and management

Abubakar Umar Anka et al.

Summary: SARS-CoV-2 infection results in COVID-19, characterized by pneumonia and acute respiratory distress syndrome. The disease triggers inflammatory responses that can cause tissue damage, along with reduced immune cells and cytokine storm in severe cases. Treatment involves antiviral agents and immunomodulators, with varied efficacy, while potential options continue to be explored for combating COVID-19 severity and transmission.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2021)

Letter Cardiac & Cardiovascular Systems

D-dimer levels predict COVID-19 severity and mortality

Kurt Ruetzler et al.

KARDIOLOGIA POLSKA (2021)

Article Multidisciplinary Sciences

Prevalence and predictors of Post-Acute COVID-19 Syndrome (PACS) after hospital discharge: A cohort study with 4 months median follow-up

Imad M. Tleyjeh et al.

Summary: The study evaluated COVID-19 survivors post discharge and found that dyspnea, cough, and fatigue were common symptoms at 4 months after discharge. Risk factors for new or persistent symptoms included female gender, pre-existing hypertension, and longer hospital stays. Age, pre-existing lung disease, and emergency room visits were associated with not fully recovering from acute COVID-19. Patients treated with interferon beta-1b based triple antiviral therapy during hospital stay were less likely to have ongoing symptoms and more likely to return to baseline health.

PLOS ONE (2021)

Article Biochemistry & Molecular Biology

Attributes and predictors of long COVID

Carole H. Sudre et al.

Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.

NATURE MEDICINE (2021)

Letter Medicine, General & Internal

Sequelae in Adults at 6 Months After COVID-19 Infection

Jennifer K. Logue et al.

JAMA NETWORK OPEN (2021)

Article Medicine, General & Internal

Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19

Maxime Taquet et al.

Summary: This study investigated the incidence and co-occurrence of long-COVID features in COVID-19 survivors, with comparisons to influenza patients, using electronic health records data. The findings showed that long-COVID clinical features were more commonly reported after COVID-19 infection, and differences were associated with sex, age, and illness severity.

PLOS MEDICINE (2021)

Article Medicine, General & Internal

Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19

Luc Morin et al.

Summary: After 4 months of hospitalization for COVID-19, a significant proportion of patients reported new symptoms and abnormalities in lung scans were common. Further research is needed to understand the long-term consequences of COVID-19.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Multidisciplinary Sciences

High-dimensional characterization of post-acute sequelae of COVID-19

Ziyad Al-Aly et al.

Summary: This study comprehensively describes the post-acute sequelae of COVID-19 using national healthcare databases, finding increased risk of death and use of health resources beyond the first 30 days of illness, as well as incident sequelae in various organ systems, increased use of therapeutic agents, and evidence of laboratory abnormalities. The findings show a risk gradient according to the severity of acute COVID-19 infection and highlight the burden of health loss experienced by patients who survive the acute phase.

NATURE (2021)

Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

Letter Emergency Medicine

Lactate dehydrogenase level as a COVID-19 severity marker

Lukasz Szarpak et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

Article Medicine, General & Internal

1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study

Lixue Huang et al.

LANCET (2021)

Article Multidisciplinary Sciences

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of in COVID-19

Magda Lourda et al.

Summary: This study utilized high-dimensional flow cytometry to analyze the immunophenotyping of granulocytes in COVID-19 patients, revealing increased levels of neutrophils and decreased counts of eosinophils and basophils in severe cases. Different immunotypes were associated with distinct sets of inflammatory markers and could predict key clinical features of the disease, suggesting potential value in clinical management.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

Sandra Lopez-Leon et al.

Summary: This study aimed to identify studies assessing the long-term effects of COVID-19, estimating that 80% of infected patients will develop one or more long-term symptoms, with the most common being fatigue, headache, attention disorder, hair loss, and dyspnea.

SCIENTIFIC REPORTS (2021)

Review Medicine, General & Internal

Long covid-mechanisms, risk factors, and management

Harry Crook et al.

Summary: The long-term effects of covid-19 can affect multiple systems in the body, leading to persistent symptoms that impact patients of varying severity. These symptoms include fatigue, dyspnea, and cognitive impairment, among others. Studies discuss risk factors for acute and long covid, as well as potential therapeutic options.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Review Immunology

COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and Mortality

Radheshyam Maurya et al.

Summary: Obesity is a significant risk factor in coronavirus infection, particularly in leading to severe illness and increased mortality rates during the pandemic. Leptin, a hormone secreted by adipocytes in proportion to body fat mass, plays a crucial role in regulating appetite and immunity, with leptin deficiency or resistance linked to dysregulation of cytokine secretion and increased susceptibility to autoimmune disorders, inflammatory responses, and infectious diseases. The dysregulation of leptin activity in obese patients may contribute to high mortality rates during SARS-CoV-2 infection.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, General & Internal

Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19

Baolin Liao et al.

Summary: This study evaluated the dynamic changes of immunological and radiographic features in COVID-19 patients, finding that severe patients had decreased lymphocyte counts, increased neutrophils, and elevated IL-6 levels. Prolonged elevation of IL-6 was associated with persistent pulmonary lesions in these patients, suggesting that monitoring and intervention of IL-6 may benefit the clinical management of COVID-19.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

Article Medicine, General & Internal

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China

Dawei Wang et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Allergy

Type 2 immunity in the skin and lungs

Cezmi A. Akdis et al.

ALLERGY (2020)

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Letter Medicine, General & Internal

Persistent Symptoms in Patients After Acute COVID-19

Angelo Carfi et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Letter Respiratory System

Patient-reported outcome measures after COVID-19: a prospective cohort study

Alyson W. Wong et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

Editorial Material Medicine, General & Internal

Management of post-acute covid-19 in primary care

Trisha Greenhalgh et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Editorial Material Medicine, General & Internal

Long-term Health Consequences of COVID-19

Carlos del Rio et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Medicine, General & Internal

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-analysis

Jonathan A. C. Sterne et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Editorial Material Medicine, General & Internal

A living WHO guideline on drugs for covid-19

Francois Lamontagne et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

Article Immunology

The known unknowns of T cell immunity to COVID-19

Annika C. Karlsson et al.

SCIENCE IMMUNOLOGY (2020)

Review Immunology

Eosinophils in Autoimmune Diseases

Nicola L. Diny et al.

FRONTIERS IN IMMUNOLOGY (2017)

Review Biochemistry & Molecular Biology

Glucocorticoid-induced skeletal muscle atrophy

O. Schakman et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

PPARβ/δ Regulates Glucocorticoid- and Sepsis-Induced FOXO1 Activation and Muscle Wasting

Estibaliz Castillero et al.

PLOS ONE (2013)