Journal
JOURNAL OF CLINICAL MEDICINE
Volume 12, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/jcm12103478
Keywords
multiple system atrophy; dysautonomia; functional neuroimaging testing; diagnostic accuracy; Ioflupane-123; cross-sectional study
Categories
Ask authors/readers for more resources
The study aimed to evaluate the effectiveness of [I-123]Ioflupane SPECT in diagnosing MSA at the initial clinical suspicion. The results showed that SPECT had high sensitivity and positive predictive value, making it a useful tool for diagnosing MSA and distinguishing between subtypes.
Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder that has no curative treatment. Diagnosis is based on a set of criteria established by Gilman (1998 and 2008) and recently updated by Wenning (2022). We aim to determine the effectiveness of [I-123]Ioflupane SPECT in MSA, especially at the initial clinical suspicion. Methods: A cross-sectional study of patients at the initial clinical suspicion of MSA, referred for [I-123]Ioflupane SPECT. Results: Overall, 139 patients (68 men, 71 women) were included, 104 being MSA-probable and 35 MSA-possible. MRI was normal in 89.2%, while SPECT was positive in 78.45%. SPECT showed high sensitivity (82.46%) and positive predictive value (86.24), reaching maximum sensitivity in MSA-P (97.26%). Significant differences were found when relating both SPECT assessments in the healthy-sick and inconclusive-sick groups. We also found an association when relating SPECT to the subtype (MSA-C or MSA-P), as well as to the presence of parkinsonian symptoms. Lateralization of striatal involvement was detected (left side). Conclusions: [I-123]Ioflupane SPECT is a useful and reliable tool for diagnosing MSA, with good effectiveness and accuracy. Qualitative assessment shows a clear superiority when distinguishing between the healthy-sick categories, as well as between the parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes at initial clinical suspicion.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available