Rotational Thromboelastometry (ROTEM®) in Relation to Inflammatory Biomarkers and Clinical Outcome in COVID-19 Patients

Article Cardiac & Cardiovascular Systems

Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium

Diana A. Gorog et al.

Summary: COVID-19 predisposes patients to thrombotic and thromboembolic events. Numerous biomarkers have emerged to assess the thrombotic risk in these patients, informing prognosis and predicting thrombosis.

NATURE REVIEWS CARDIOLOGY (2022)

Add to Collection

Review Medicine, General & Internal

The Non-Activated Thromboelastometry (NATEM) Assay's Application among Adults and Neonatal/Pediatric Population: A Systematic Review

Petroula Georgiadou et al.

Summary: The non-activated thromboelastometry (NATEM) assay provides a comprehensive insight into the actual hemostatic mechanism. However, its use in clinical practice is not well-documented. A systematic review found limited data on NATEM's ability to detect hemostasis disorders, but some studies suggest it may have advantages in detecting hyperfibrinolysis and diagnosing hemostatic disorders.

DIAGNOSTICS (2022)

Add to Collection

Article Medicine, Research & Experimental

Inflammatory and thrombotic parameters associated with the COVID-19 course in Poland (SARSTer study)

Piotr Czupryna et al.

Summary: The aim of the study was to assess the coagulation and inflammatory markers associated with the severe course of COVID-19 and lack of clinical improvement. The study found that a severe course of the disease was associated with lower platelet and lymphocyte counts, higher D-dimer, CRP, neutrophil count, and IL-6 concentration. The best predictors of no clinical improvement in COVID-19 were IL-6>100 pg/ml, D-dimer>1000 ng/ml, and PLT<150,000/μl.

ADVANCES IN MEDICAL SCIENCES (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

C-reactive protein and clinical outcomes in patients with COVID-19

Nathaniel R. Smilowitz et al.

Summary: Elevated CRP levels at initial hospital presentation in COVID-19 patients are associated with an increased risk of venous thromboembolism, acute kidney injury, critical illness, and mortality. There is a dose-response relationship between CRP concentration and adverse outcomes, with patients with high levels of both CRP and D-dimer showing the greatest risk of adverse outcomes. Systemic inflammation, as measured by CRP, plays a significant role in predicting clinical outcomes in COVID-19.

EUROPEAN HEART JOURNAL (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

Sean X. Gu et al.

Summary: Platelet and endothelial dysfunction are essential components of COVID-19 pathology, while cardiovascular risk factors exacerbate the severity of the disease. Patients with pre-existing cardiovascular disease and risk factors are at the highest risk of death from COVID-19.

NATURE REVIEWS CARDIOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients

Yu Zuo et al.

Summary: COVID-19 patients have elevated levels of tPA and PAI-1 in plasma, which are correlated with neutrophil counts and respiratory status. Particularly high levels of tPA are strongly associated with mortality and enhanced fibrinolysis, suggesting a subset of patients may have a favorable balance of factors for fibrinolysis. Further investigation into tPA as a biomarker is warranted.

SCIENTIFIC REPORTS (2021)

Add to Collection

Review Medicine, General & Internal

The Role of TEG Analysis in Patients with COVID-19-Associated Coagulopathy: A Systematic Review

Jan Hartmann et al.

Summary: COVID-19-associated coagulopathy (CAC) characterized by hypercoagulability and increased risk of thrombotic complications can be identified and predicted using thromboelastography (TEG®). Thromboelastography plays an important role in managing patients with COVID-19.

DIAGNOSTICS (2021)

Add to Collection

Review Critical Care Medicine

Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019 A Systematic Review and Meta-analysis

David Jimenez et al.

Summary: The pooled incidence of VTE and bleeding among hospitalized patients with COVID-19 was 17.0% and 7.8% respectively. Factors such as routine screening, critical illness, inclusion of distal DVT and subsegmental PE, and prospective studies were associated with higher rates of VTE. The incidence of bleeding events was sensitive to escalated doses of anticoagulants and the nature of data collection.

CHEST (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The Central Role of Fibrinolytic Response in COVID-19-A Hematologist's Perspective

Hau C. Kwaan et al.

Summary: COVID-19 shares similar characteristics with SARS and MERS, such as high contagiousness and severe pulmonary complications. The involvement of the fibrinolytic system plays a key role in the pathogenesis of these viral illnesses, affecting various organs throughout the body. Understanding the central role of fibrinolysis may provide insights into potential drug targets for these respiratory diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Medicine, General & Internal

Viscoelastometric Testing to Assess Hemostasis of COVID-19: A Systematic Review

Marion Bareille et al.

Summary: The use of viscoelastometric testing (VET) in COVID-19 patients revealed hypercoagulability and impaired fibrinolysis, but studies did not support a direct association with thrombotic events.

JOURNAL OF CLINICAL MEDICINE (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Serial EXTEM, FIBTEM, and tPA Rotational Thromboelastometry Observations in the Maastricht Intensive Care COVID Cohort-Persistence of Hypercoagulability and Hypofibrinolysis Despite Anticoagulation

Anne-Marije Hulshof et al.

Summary: This study found that ROTEM tests in COVID-19 ICU patients show persistent hypercoagulability and severe hypofibrinolysis lasting for at least 6 weeks.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Add to Collection

Article Hematology

Thrombogenicity markers for early diagnosis and prognosis in COVID-19: a change from the current paradigm?

Paul A. Gurbel et al.

Summary: This study investigates the diagnostic and prognostic utility of thromboelastography in COVID-19 patients, finding that COVID-19 positive patients have higher platelet-fibrin clot strength, fibrin clot strength, and functional fibrinogen level. High TEG-6s metrics better discriminate COVID-19 positive patients from negative ones.

BLOOD COAGULATION & FIBRINOLYSIS (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

International COVID-19 thrombosis biomarkers colloquium: COVID-19 diagnostic tests

Paul A. Gurbel et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

Add to Collection

Article Medicine, General & Internal

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

Ewan C. Goligher et al.

Summary: In critically ill patients with Covid-19, initial therapeutic-dose anticoagulation did not result in improved survival rates or fewer days requiring cardiovascular or respiratory organ support compared to usual-care pharmacologic thromboprophylaxis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Article Multidisciplinary Sciences

Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19

Abakar Magomedov et al.

Summary: COVID-19 patients showed a hypercoagulable state during acute illness, but three months later, follow-up examinations revealed normalization of coagulation abnormality without evidence of venous thrombosis. Discontinuation of anticoagulation can be considered in patients with complete venous reperfusion based on these findings.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Critical Care Medicine

Platelet activation in critically ill COVID-19 patients

Nader Yatim et al.

Summary: This study found that elevated soluble P-selectin levels at admission were associated with COVID-19 severity and could predict intubation and death. Gene expression analysis indicated that critically ill patients had increased expression of genes related to platelet activation, with specific genes showing grade-dependent upregulation. ROC curve analysis identified PPBP/CXCL7 and SELPLG as biomarkers for intubation.

ANNALS OF INTENSIVE CARE (2021)

Add to Collection

Article Hematology

Hemostasis and fibrinolysis in COVID-19 survivors 6 months after intensive care unit discharge

Anne-Marije Hulshof et al.

Summary: This study evaluated changes in hemostasis laboratory parameters and tPA ROTEM 6 months after COVID-19 ICU discharge. The results showed normalization of tPA ROTEM parameters, but some patients still had elevated D-dimer and fibrinogen concentrations up to 6 months after discharge, indicating the need for further exploration into the role of hemostasis in long-term morbidity after hospital discharge.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2021)

Add to Collection

Review Medicine, General & Internal

Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis

Preeti Malik et al.

Summary: This study found a significant association between lymphopenia, thrombocytopenia, and elevated levels of CRP, PCT, LDH, D-dimer, and COVID-19 severity. These results have the potential to be used as early biomarkers to improve the management of COVID-19 patients by identifying high-risk patients and allocating healthcare resources appropriately in the pandemic.

BMJ EVIDENCE-BASED MEDICINE (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

C-reactive protein and clinical outcomes in patients with COVID-19

Nathaniel R. Smilowitz et al.

Summary: Elevated CRP levels upon hospital admission in COVID-19 patients are associated with increased risks of VTE, AKI, critical illness, and mortality, suggesting a crucial role of systemic inflammation in the clinical course of COVID-19.

EUROPEAN HEART JOURNAL (2021)

Add to Collection

Editorial Material Hematology