Journal
JOURNAL OF CLINICAL MEDICINE
Volume 12, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/jcm12072506
Keywords
chondrosarcoma; review; sarcoma
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Chondrosarcomas are malignant cartilaginous matrix-producing tumors, with a spectrum of biologic activity ranging from low-grade to high-grade tumors. Diagnosis, treatment, and prognosis vary based on the histologic grade of the tumor. Distinguishing between high-grade and intermediate-grade chondrosarcomas, as well as low-grade tumors and benign enchondromas, poses a diagnostic challenge. A multidisciplinary team at a tertiary sarcoma center provides optimal care for these patients.
Chondrosarcomas are a diverse group of malignant cartilaginous matrix-producing neoplasms. Conventional chondrosarcomas are a continuum of disease based on the biologic activity of the tumor. The tumors range from the relatively biologically benign low-grade tumors or intermediate atypical cartilaginous tumors (ACTs), to malignant, aggressive high-grade tumors. The clinical presentation, radiographic and pathologic findings, treatments and outcomes vary significantly based on the histologic grade of the tumor. Chondrosarcomas present a diagnostic dilemma, particularly in the differentiation between high- and intermediate-grade tumors and that of low-grade tumors from benign enchondromas. A multidisciplinary team at a tertiary sarcoma centre allows for optimal care of these patients.
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