Autocatalytic effect boosts the production of medium-chain hydrocarbons by fatty acid photodecarboxylase

Review Biochemistry & Molecular Biology

Photolyase Production and Current Applications: A Review

Diana Ramirez-Gamboa et al.

Summary: This study presents the functions, characteristics, and types of photolyases, their therapeutic and cosmetic applications, and additionally explores some photolyase-producing microorganisms and drug delivery systems.

MOLECULES (2022)

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Article Biochemistry & Molecular Biology

Fatty Acid Photodecarboxylase Is an Interfacial Enzyme That Binds to Lipid-Water Interfaces to Access Its Insoluble Substrate

Cyril Aselmeyer et al.

Summary: The study found that Fatty Acid Photodecarboxylase (FAP) prefers fatty acids embedded in phospholipid liposomes and on the surface of microemulsions. Additionally, it was discovered that FAP has the ability to bind to and penetrate membranes with a higher affinity for fatty acids present.

BIOCHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Stabilisation of the Fatty Acid Decarboxylase from Chlorella variabilis by Caprylic Acid

Yinqi Wu et al.

Summary: This study demonstrates that the photostability of CvFAP can be easily improved by administering medium-chain length carboxylic acids such as caprylic acid. The best way to maintain CvFAP stability is shown to be 'to keep the enzyme busy'.

CHEMBIOCHEM (2021)

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Article Multidisciplinary Sciences

Mechanism and dynamics of fatty acid photodecarboxylase

D. Sorigue et al.

Summary: The study found that Fatty Acid Photodecarboxylase (FAP) exhibits efficient decarboxylation activity, primarily achieved through the reduction of the flavin chromophore and direct removal of carbon dioxide by the substrate carboxyl group. Essential residues R451 and C432 are crucial for substrate stabilization and charge transfer.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase

Jian Xu et al.

Summary: The research utilizes a photodecarboxylase from Chlorella variabilis NC64A for enzymatic deuterium incorporation, identifying enzyme variants able to process substrates of different chain lengths. Specific mutants successfully convert various substrates into deuterated products, allowing for the stereoselective conversion of chiral acids.

NATURE COMMUNICATIONS (2021)

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Article Plant Sciences

Fatty acid photodecarboxylase is an ancient photoenzyme that forms hydrocarbons in the thylakoids of algae

Solene L. Y. Moulin et al.

Summary: Fatty acid photodecarboxylase (FAP) is a photoenzyme that requires light for catalytic cycle, and recent studies have shown its conservation and role in the formation of hydrocarbons in algae such as Chlamydomonas reinhardtii. This enzyme is predominantly membrane-associated and its activity is linked to photosynthetic membranes, suggesting a potentially important role in the evolution and function of algal lineages.

PLANT PHYSIOLOGY (2021)

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Review Plant Sciences

Photocatalysis as the 'master switch' of photomorphogenesis in early plant development

Derren J. Heyes et al.

Summary: LPOR is a light-activated enzyme essential for chlorophyll biosynthesis and plant greening. It catalyzes the conversion of protochlorophyllide to chlorophyllide, playing a crucial role in early plant development. Through photocatalysis, LPOR acts as a master switch for plant photomorphogenesis, triggering complex molecular and cellular events that lead to plant morphological changes.

NATURE PLANTS (2021)

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Article Chemistry, Multidisciplinary