Atroposelective remote meta-C-H arylation of 2-arylanilines

Enantioselective remote C-H activation is a challenging task in organic chemistry, and atroposelective synthesis of remotely substituted axially chiral molecules via direct C-H activation remains elusive. In this issue of Chem, Yu, Wang, and co-workers report an atroposelective meta-C-H arylation of 2-arylanilines via an enantioselective palladation relay strategy.

Automated summary

Enantioselective remote C-H activation is a challenging task in organic chemistry, and atroposelective synthesis of remotely substituted axially chiral molecules via direct C-H activation remains elusive. In this issue of Chem, Yu, Wang, and co-workers report an atroposelective meta-C-H arylation of 2-arylanilines via an enantioselective palladation relay strategy.