Journal
CHEM
Volume 9, Issue 5, Pages 1069-1071Publisher
CELL PRESS
DOI: 10.1016/j.chempr.2023.04.016
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The study presents a chemical trapping method to investigate short-lived intermediate states in substrate ubiquitylation. The effectiveness of this approach is demonstrated by determining single-particle cryo-EM structures related to nucleosome ubiquitylation.
Characterization of short-lived intermediate states along the path of a ubiquitylation reaction remains challenging. In this issue of Chem, Ai et al. present a chemical trapping method for probing transient intermediates in substrate ubiquitylation. The usefulness of this approach is demonstrated by the determination of single-particle cryoelectron microscopy (cryo-EM) structures related to nucleo-some ubiquitylation.
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