4.8 Editorial Material

A chemical strategy to study transient states in substrate ubiquitylation by cryo-EM

Journal

CHEM
Volume 9, Issue 5, Pages 1069-1071

Publisher

CELL PRESS
DOI: 10.1016/j.chempr.2023.04.016

Keywords

-

Ask authors/readers for more resources

The study presents a chemical trapping method to investigate short-lived intermediate states in substrate ubiquitylation. The effectiveness of this approach is demonstrated by determining single-particle cryo-EM structures related to nucleosome ubiquitylation.
Characterization of short-lived intermediate states along the path of a ubiquitylation reaction remains challenging. In this issue of Chem, Ai et al. present a chemical trapping method for probing transient intermediates in substrate ubiquitylation. The usefulness of this approach is demonstrated by the determination of single-particle cryoelectron microscopy (cryo-EM) structures related to nucleo-some ubiquitylation.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available