4.8 Article

Influence of structural dynamics on cell uptake investigated with single-chain polymeric nanoparticles

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Elucidating the Stability of Single-Chain Polymeric Nanoparticles in Biological Media and Living Cells

Linlin Deng et al.

Summary: The controlled folding of synthetic polymer chains into single-chain polymeric nanoparticles (SCPNs) in water is a viable method for creating compartmentalized, nanometer-sized structures for various biological applications. Understanding the relationship between polymer microstructure and folded structure stability is crucial. Through introducing a solvatochromic dye and using spectroscopic and microscopic techniques, the study found that the polymer's microstructure plays a vital role in ensuring nanoparticle stability in competitive environments.

BIOMACROMOLECULES (2022)

Review Nanoscience & Nanotechnology

Drug delivery to the central nervous system

Elizabeth Nance et al.

Summary: The central nervous system is protected by tightly regulated physiological barriers, making drug delivery into the brain and spinal cord very challenging. This Review discusses the pathophysiological changes that complicate drug delivery into the central nervous system and examines materials-based strategies to bypass or overcome these barriers for drug delivery.

NATURE REVIEWS MATERIALS (2022)

Article Polymer Science

Solvent Remodeling in Single-Chain Amphiphilic Heteropolymer Systems

Shayna L. Hilburg et al.

Summary: This study demonstrates the remodeling of single-chain nanoparticles upon a transition to organic solvent through molecular dynamics simulations, highlighting the pivotal role of electrostatic interactions.

MACROMOLECULAR RAPID COMMUNICATIONS (2022)

Article Chemistry, Multidisciplinary

Dynamic Polymer Amphiphiles for Efficient Intracellular and In Vivo Protein Delivery

Jingke Xu et al.

Summary: This research proposes a strategy for efficient intracellular protein delivery using dynamic polymer supra-amphiphiles, which promote the protein delivery process through the formation of dynamic supramolecular structures, showing great potential in treating diseases such as ulcerative colitis in vivo.

ADVANCED MATERIALS (2021)

Article Nanoscience & Nanotechnology

Mechanochemical Cellular Membrane Internalization of Nanohydrogels: A Large-Scale Mesoscopic Simulation

Xianyu Song et al.

Summary: The study reveals that the behavior of nanohydrogels in cellular internalization pathways is determined by their crosslink density and encapsulation ability, leading to different internalization modes for homogeneous and heterogeneous nanohydrogels. Additionally, both homogeneous and heterogeneous nanohydrogels undergo dual morphological deformations during internalization, but the heterogeneous ones exhibit reduced contact area with the membrane, thereby avoiding potential cellular toxicity.

ACS APPLIED MATERIALS & INTERFACES (2021)

Article Polymer Science

Control and Characterization of the Compactness of Single-Chain Nanoparticles

Suiyang Liao et al.

Summary: The compactness of single-chain polymer nanoparticles (SCNPs) can be controlled by initial reaction conditions and the length of cross-linking molecules. Short cross-linking molecules may result in less compact SCNPs, while precollapsed chains lead to more compact particles after cross-linking. The toxicity of particles interacting with HeLa cells differs depending on their compactness, with more compact ones being less toxic.

MACROMOLECULES (2021)

Article Chemistry, Multidisciplinary

Regulation of Proteins to the Cytosol Using Delivery Systems with Engineered Polymer Architecture

Jessica A. Kretzmann et al.

Summary: Modulation of surface functionality significantly affects overall delivery efficiency, while manipulation of polymer architecture can highly regulate endosomal release rate.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Polymer Science

Cytosolic Delivery of Single-Chain Polymer Nanoparticles

Naomi M. Hamelmann et al.

Summary: This study presents a strategy to control the intracellular delivery of SCNP nanoparticles by surface modification, improving targeting efficiency for biomedical applications.

ACS MACRO LETTERS (2021)

Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

Review Chemistry, Multidisciplinary

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

Mauro Sousa de Almeida et al.

Summary: Nanoparticles have diverse applications, particularly in nanomedicine for detecting and treating diseases like cancer and inflammation. Understanding the mechanisms of cellular uptake and intracellular localization of nanoparticles is crucial for therapeutic applications. Factors such as physicochemical properties, endocytic pathways, and cellular uptake regulators play key roles in the application of nanoparticles in medicine.

CHEMICAL SOCIETY REVIEWS (2021)

Review Nanoscience & Nanotechnology

Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices

Francisca Villanueva-Flores et al.

NANOTECHNOLOGY (2020)

Review Pharmacology & Pharmacy

Engineering the drug carrier biointerface to overcome biological barriers to drug delivery

Joel A. Finbloom et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Pharmacology & Pharmacy

Lipid nanoparticles for nucleic acid delivery: Current perspectives

Eleni Samaridou et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

Review Chemistry, Multidisciplinary

Role of Nanoparticle Mechanical Properties in Cancer Drug Delivery

Yue Hui et al.

ACS NANO (2019)

Article Polymer Science

Shape-Adaptive Single-Chain Nanoparticles Interacting with Lipid Membranes

Yachong Guo et al.

MACROMOLECULES (2019)

Article Polymer Science

Glucose Single-Chain Polymer Nanoparticles for Cellular Targeting

A. Pia P. Kroger et al.

ACS MACRO LETTERS (2019)

Article Chemistry, Multidisciplinary

Counting loops in sidechain-crosslinked polymers from elastic solids to single-chain nanoparticles

Junpeng Wang et al.

CHEMICAL SCIENCE (2019)

Article Physics, Condensed Matter

Effect of chain stiffness on the structure of single-chain polymer nanoparticles

Angel J. Moreno et al.

JOURNAL OF PHYSICS-CONDENSED MATTER (2018)

Review Chemistry, Multidisciplinary

Block Copolymer Micelles in Nanomedicine Applications

Horacio Cabral et al.

CHEMICAL REVIEWS (2018)

Review Polymer Science

Entry of nanoparticles into cells: the importance of nanoparticle properties

Jiacheng Zhao et al.

POLYMER CHEMISTRY (2018)

Review Chemistry, Multidisciplinary

Cellular Uptake of Nanoparticles versus Small Molecules: A Matter of Size

Jesus Mosquera et al.

ACCOUNTS OF CHEMICAL RESEARCH (2018)

Review Chemistry, Multidisciplinary

Liposomes and polymersomes: a comparative review towards cell mimicking

Emeline Rideau et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Chemistry, Multidisciplinary

Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging

A. Pia P. Kroger et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Materials Science, Biomaterials

The great escape: how cationic polyplexes overcome the endosomal barrier

Tanja Bus et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

Review Nanoscience & Nanotechnology

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

Parisa Foroozandeh et al.

NANOSCALE RESEARCH LETTERS (2018)

Review Pharmacology & Pharmacy

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

Sophia G. Antimisiaris et al.

PHARMACEUTICS (2018)

Article Polymer Science

Swelling Behavior of Single-Chain Polymer Nanoparticles: Theory and Simulation

Hauke Rabbel et al.

MACROMOLECULES (2017)

Article Chemistry, Multidisciplinary

Peptide/Cas9 nanostructures for ribonucleoprotein cell membrane transport and gene edition

Irene Lostale-Seijo et al.

CHEMICAL SCIENCE (2017)

Review Chemistry, Multidisciplinary

Intramolecular Cross-Linking Methodologies for the Synthesis of Polymer Nanoparticles

Sudheendran Mavila et al.

CHEMICAL REVIEWS (2016)

Review Pharmacology & Pharmacy

Extracellular vesicles for drug delivery

Pieter Vader et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Article Polymer Science

A Solvent-Based Strategy for Tuning the Internal Structure of Metallo-Folded Single-Chain Nanoparticles

Senda Basasoro et al.

MACROMOLECULAR RAPID COMMUNICATIONS (2016)

Review Chemistry, Multidisciplinary

Physical Principles of Nanoparticle Cellular Endocytosis

Sulin Zhang et al.

ACS NANO (2015)

Review Cell Biology

Effect of the surface modification, size, and shape on cellular uptake of nanoparticles

Sara Salatin et al.

CELL BIOLOGY INTERNATIONAL (2015)

Article Chemistry, Multidisciplinary

Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo

Margie Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Review Pharmacology & Pharmacy

The importance of nanoparticle shape in cancer drug delivery

Nghia P. Truong et al.

EXPERT OPINION ON DRUG DELIVERY (2015)

Review Medicine, General & Internal

Emerging concepts in dendrimer-based nanomedicine: from design principles to clinical applications

R. M. Kannan et al.

JOURNAL OF INTERNAL MEDICINE (2014)

Review Polymer Science

Dendrimer as nanocarrier for drug delivery

Prashant Kesharwani et al.

PROGRESS IN POLYMER SCIENCE (2014)

Article Polymer Science

How Far Are Single-Chain Polymer Nanoparticles in Solution from the Globular State?

Jose A. Pomposo et al.

ACS MACRO LETTERS (2014)

Article Biochemistry & Molecular Biology

Improved Assays for Determining the Cytosolic Access of Peptides, Proteins, and Their Mimetics

Justin M. Holub et al.

BIOCHEMISTRY (2013)

Review Engineering, Biomedical

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

Alexandre Albanese et al.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 14 (2012)

Review Chemistry, Multidisciplinary

Design of polymeric nanoparticles for biomedical delivery applications

Mahmoud Elsabahy et al.

CHEMICAL SOCIETY REVIEWS (2012)

Review Chemistry, Multidisciplinary

Polymersomes for drug delivery: Design, formation and characterization

Jung Seok Lee et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Polymer Science

Single-chain polymer nanoparticles via reversible disulfide bridges

Bryan T. Tuten et al.

POLYMER CHEMISTRY (2012)

Review Cell Biology

On the Trail of the Glucocorticoid Receptor: Into the Nucleus and Back

Sofie Vandevyver et al.

TRAFFIC (2012)

Review Pharmacology & Pharmacy

The effects of polymeric nanostructure shape on drug delivery

Shrinivas Venkataraman et al.

ADVANCED DRUG DELIVERY REVIEWS (2011)

Review Chemistry, Multidisciplinary

Endosomal escape pathways for delivery of biologicals

Amir K. Varkouhi et al.

JOURNAL OF CONTROLLED RELEASE (2011)

Article Chemistry, Multidisciplinary

Controlled folding of synthetic polymer chains through the formation of positionable covalent bridges

Bernhard V. K. J. Schmidt et al.

NATURE CHEMISTRY (2011)

Review Chemistry, Multidisciplinary

Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials

Feng Zhao et al.

SMALL (2011)

Article Medicine, Research & Experimental

Dendrimer Internalization and Intracellular Trafficking in Living Cells

Lorenzo Albertazzi et al.

MOLECULAR PHARMACEUTICS (2010)

Review Polymer Science

Non-viral polyplexes: Scaffold mediated delivery for gene therapy

Suzanne O'Rorke et al.

PROGRESS IN POLYMER SCIENCE (2010)

Review Chemistry, Multidisciplinary

Effect of Surface Properties on Nanoparticle-Cell Interactions

Ayush Verma et al.

SMALL (2010)

Article Nanoscience & Nanotechnology

Nanoparticle-mediated cellular response is size-dependent

Wen Jiang et al.

NATURE NANOTECHNOLOGY (2008)

Article Chemistry, Physical

Counterion condensation on charged spheres, cylinders, and planes

Gerald S. Manning

JOURNAL OF PHYSICAL CHEMISTRY B (2007)

Article Biotechnology & Applied Microbiology

A high-throughput assay for assessing the cell permeability of combinatorial libraries

P Yu et al.

NATURE BIOTECHNOLOGY (2005)

Review Microbiology

Virus entry: Molecular mechanisms and biomedical applications

DS Dimitrov

NATURE REVIEWS MICROBIOLOGY (2004)

Article Biochemistry & Molecular Biology

Multiple conformational changes in enzyme catalysis

GG Hammes

BIOCHEMISTRY (2002)