Grinding the way to enantiopurification

Review Chemistry, Multidisciplinary

Polymorphs with remarkably distinct physical and/or chemical properties

Binoy K. Saha et al.

Summary: Polymorphism is a common phenomenon in crystals, where different crystal structures of the same compound lead to significant changes in materials properties. It is difficult to control polymorphism due to the close energy levels between different polymorphic forms. Polymorphism is not only of interest to academia but also has widespread applications in materials science and pharmaceutical industries.

CHEMICAL RECORD (2023)

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Article Chemistry, Multidisciplinary

NMR in operando monitoring of mechanochemically accelerated sublimations

Francesco Puccetti et al.

Summary: This study presents a setup that uses mechanochemistry to promote solid-solid interactions and couples it with nuclear magnetic resonance (NMR) to monitor the variation in real time. The system is applied to analyze optically active species responding to self-disproportionation of enantiomers by sublimation and introduces an advanced concept of enantiomer recognition based on selective sublimation.

CHEM (2023)

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Review Chemistry, Multidisciplinary

Time-Resolved In Situ Monitoring of Mechanochemical Reactions

Adam A. L. Michalchuk et al.

Summary: Mechanochemical transformations offer environmentally friendly routes for synthesis, increasing reaction speed and selectivity. Time-resolved in situ (TRIS) approaches have provided new insights into mechanochemical reactions, revealing new features and advancing our understanding through the combination of complementary techniques.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Organic