TaCl5-Catalyzed Amidation of Carboxylic Acids with Amines

The reaction of alkyl- and aryl-substituted carboxylic acids with primary and secondary amines under the action of 0.2 equiv. TaCl5 leads to selective formation of carboxylic acid amides of various structures. TaCl5-catalyzed formation of amides was demonstrated to proceed equally selectively both in toluene and methylene chloride, hexane, diethyl ether and 1,4-dioxane solutions.

Automated summary

Under the catalysis of 0.2 equiv. TaCl5, alkyl- and aryl-substituted carboxylic acids react with primary and secondary amines to selectively form carboxylic acid amides of various structures. The TaCl5-catalyzed amide formation reaction proceeds with equal selectivity in toluene and methylene chloride, hexane, diethyl ether, and 1,4-dioxane solutions.