4.7 Article

Global publication trends and research hotspots of the gut-liver axis in NAFLD: A bibliometric analysis

Related references

Note: Only part of the references are listed.
Article Food Science & Technology

Inulin intervention attenuates hepatic steatosis in rats via modulating gut microbiota and maintaining intestinal barrier function

Zhandong Yang et al.

Summary: Evidence suggests that the prebiotic inulin can mitigate nonalcoholic fatty liver disease (NAFLD), but its mechanisms of action are not well understood. This study found that inulin consumption improved hepatic steatosis and inflammation, restored liver lipogenesis regulators, and enhanced intestinal barrier integrity and function. Inulin also regulated the gut microbiota composition, increasing the abundance of beneficial bacteria and reducing opportunistic pathogens. Furthermore, inulin intervention affected tryptophan metabolism and altered fecal metabolite levels in NAFLD rats. These findings suggest that inulin intake may be a novel approach for the prevention and treatment of NAFLD.

FOOD RESEARCH INTERNATIONAL (2023)

Article Pharmacology & Pharmacy

Amlodipine, an anti-hypertensive drug, alleviates non-alcoholic fatty liver disease by modulating gut microbiota

Yang Li et al.

Summary: Amlodipine has potential therapeutic effects on NAFLD combined with hypertension by modulating gut microbiota.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Article Gastroenterology & Hepatology

The fecal mycobiome in non-alcoholic fatty liver disease

Munevver Demir et al.

Summary: The study found that the fecal fungal composition of patients with non-alcoholic fatty liver disease (NAFLD) is associated with disease severity. Non-obese NAFLD patients have a distinct fungal ratio in their feces compared to other types of patients. Antifungal treatment in a mouse model can reduce liver damage from steatohepatitis.

JOURNAL OF HEPATOLOGY (2022)

Review Gastroenterology & Hepatology

Treatment Candidacy for Pharmacologic Therapies for NASH

Ian A. Rowe et al.

Summary: NASH has become an important cause of cirrhosis and hepatocellular carcinoma, and there are currently more than 50 therapeutic agents in clinical development. Obeticholic acid has achieved interim histological improvement in fibrosis without worsening NASH in the phase 3 REGENERATE study, and long-term clinical outcomes are being followed. It is now a timely consideration of the current situation and future direction in NASH management.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Nutrition & Dietetics

Non-alcoholic fatty liver disease: a multi-system disease influenced by ageing and sex, and affected by adipose tissue and intestinal function

Josh Bilson et al.

Summary: NAFLD is a multi-system disease that affects organs beyond the liver, with risk influenced by age and gender, as well as changes in white adipose tissue and intestinal function.

PROCEEDINGS OF THE NUTRITION SOCIETY (2022)

Article Immunology

Knowledge Mapping of Immunotherapy for Hepatocellular Carcinoma: A Bibliometric Study

Jianming Shen et al.

Summary: This study conducted a bibliometric analysis on immunotherapy for hepatocellular carcinoma (HCC) to gain a better understanding of the current situation and potential new research directions. The study found that China is the main research country in this field, with the number of articles increasing every year. The current research hotspots include the immunological landscape of liver cancer, screening of eligible populations for immunotherapy, and the clinical application of immune checkpoint inhibitors.

FRONTIERS IN IMMUNOLOGY (2022)

Review Biochemistry & Molecular Biology

Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives

Natalia Vallianou et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, often starting as a benign liver fat accumulation that can progress to non-alcoholic steatohepatitis (NASH) and increase the risk of cirrhosis and hepatocellular carcinoma (HCC). Recent studies have highlighted the role of gut dysbiosis, which can lead to increased gut permeability and the release of toxic bacterial products and proinflammatory cytokines, causing and sustaining inflammation. The composition of the gut microbiota and various metabolites may vary during different stages of NAFLD and among population groups, and further research is needed to determine the causal relationship between gut microbiota profiles and NAFLD in patients. Additionally, multiple metabolites may contribute to the pathogenesis of NAFLD.

BIOMOLECULES (2022)

Article Gastroenterology & Hepatology

Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis

Masahide Enomoto et al.

Summary: The combination of rifaximin and lubiprostone has been shown to effectively suppress the progression of liver fibrosis in non-alcoholic steatohepatitis (NASH) by modulating gut barrier function. This treatment strategy reduces macrophage expansion, inflammatory responses, and liver fibrosis by blocking the translocation of gut-derived lipopolysaccharide (LPS) and inhibiting toll-like receptor 4 signaling. In addition, rifaximin and lubiprostone restore intestinal permeability, improve the abundance of beneficial bacteria, and increase the production of short-chain fatty acids, contributing to the overall improvement of NASH-related fibrosis.

DIGESTIVE AND LIVER DISEASE (2022)

Article Multidisciplinary Sciences

A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease

Runtan Cheng et al.

Summary: Exercise and diet interventions have a therapeutic effect on nonalcoholic fatty liver disease (NAFLD) and prediabetes patients. This study found that combined aerobic exercise and diet intervention can diversify and stabilize the keystone taxa in the gut microbiome. Exploratory analysis suggests that gut microbial network may be used to predict individual liver fat response to exercise intervention if validated in future studies.

NATURE COMMUNICATIONS (2022)

Article Immunology

A Bibliometric and Knowledge-Map Analysis of CAR-T Cells From 2009 to 2021

Lele Miao et al.

Summary: This study uses bibliometric and knowledge-map analysis to explore the evolution and development trends of hotspots in the CAR-T cell field. The results show that the United States is in the leading position in this research field, and the research hotspots include the application of CAR-T cells in hematological malignancies and the related research of cytokine release syndrome (CRS). In addition, the study of CAR-T cells in solid tumors is also a rapidly developing hotspot in this field.

FRONTIERS IN IMMUNOLOGY (2022)

Article Gastroenterology & Hepatology

Aldafermin in patients with non-alcoholic steatohepatitis (ALPINE 2/3): a randomised, double-blind, placebo-controlled, phase 2b trial

Stephen A. Harrison et al.

Summary: The study aimed to evaluate the safety and efficacy of aldafermin in patients with non-alcoholic steatohepatitis (NASH), but did not demonstrate a significant dose response.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

A Freshwater Fish-Based Diet Alleviates Liver Steatosis by Modulating Gut Microbiota and Metabolites: A Clinical Randomized Controlled Trial in Chinese Participants With Nonalcoholic Fatty Liver Disease

He Kaiyin et al.

Summary: This study found that increasing the intake of freshwater fish can regulate gut microbiota and its metabolites, benefiting patients with NAFLD. Moreover, alternating intake of freshwater fish and red meat does not exacerbate NAFLD.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2022)

Article Multidisciplinary Sciences

Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism

Yuanyuan Lei et al.

Summary: Disulfiram (DSF) reduces Clostridium-mediated 7 alpha-dehydroxylation activity to suppress secondary bile acid biosynthesis and ameliorate NASH in mice. A self-controlled clinical trial also validates DSF regulation of the gut-liver axis in healthy men.

NATURE COMMUNICATIONS (2022)

Article Nutrition & Dietetics

Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study

Thananya Jinato et al.

Summary: This study provides evidence that oligonol improves liver steatosis by modulating gut bacterial composition, suggesting its potential therapeutic role in treating non-alcoholic fatty liver disease (NAFLD).

NUTRIENTS (2022)

Article Immunology

Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

Lanfeng Xue et al.

Summary: Fecal microbiota transplantation (FMT) can attenuate fat accumulation in patients with non-alcoholic fatty liver disease (NAFLD) by improving gut microbiota dysbiosis. Significant differences in clinical features and gut microbiota were observed between lean and obese NAFLD patients, with FMT showing better effects in lean NAFLD patients.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Review Cardiac & Cardiovascular Systems

The Future Landscape of Macrophage Research in Cardiovascular Disease: A Bibliometric Analysis

Xia Xu et al.

Summary: Cardiovascular disease (CVD) is currently the leading cause of morbidity and mortality in many countries, and macrophages play a key role in its development. This study analyzed the research hotspots, countries and regions, institutions, authors, core journals, and keywords related to macrophages in CVD. The study found that inflammation, immunology, autophagy, and lipidperoxidation are the main pathogenesis of CVD caused by macrophages.

CURRENT PROBLEMS IN CARDIOLOGY (2022)

Review Pharmacology & Pharmacy

Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases

Takako Ikeda et al.

Summary: Dysbiosis is associated with cellular dysfunction due to impaired production and signaling of short-chain fatty acids. Short-chain fatty acids regulate physiological processes through interaction with receptors. Recent advances in the use of prebiotics and probiotics have shown promise in disease treatment.

PHARMACOLOGY & THERAPEUTICS (2022)

Review Pharmacology & Pharmacy

Bile acid metabolism and signaling, the microbiota, and metabolic disease

Jingwei Cai et al.

Summary: The diversity, composition, and function of the bacterial community in the human gastrointestinal tract play a crucial role in host health. Bile acids, as potent metabolic and immune signaling molecules, have significant impacts on host metabolic and immunological functions. Manipulating the microbiota-bile acid-bile acid receptor axis has emerged as a novel therapeutic approach for human health.

PHARMACOLOGY & THERAPEUTICS (2022)

Article Nutrition & Dietetics

Fatty Acids and Eicosanoids Change during High-Fiber Diet in NAFLD Patients-Randomized Control Trials (RCT)

Dominika Maciejewska-Markiewicz et al.

Summary: This study analyzed the changes in fatty acids and eicosanoids in the serum of participants who consumed high-fiber rolls for 8 weeks. The results showed that a high amount of dietary fiber was associated with a reduction in fatty liver. Regardless of the amount of fiber consumed, significant changes in the profile of fatty acids and eicosanoids were observed, reflecting positive changes in liver metabolism.

NUTRIENTS (2022)

Article Immunology

A bibliometric analysis of T cell and atherosclerosis

Namin Wei et al.

Summary: This article presents a bibliometric analysis of T cells and atherosclerosis (AS), providing insights into the research trends and hotspots in this field. The analysis reveals that the field has demonstrated stability over the past decade and identifies potential partners for further research. The current research hotspots include inflammatory and immune mechanisms, related diseases, and cytokines of AS. B cells, mortality, inhibition, and monocytes are identified as the emerging frontiers of research in this field.

FRONTIERS IN IMMUNOLOGY (2022)

Article Gastroenterology & Hepatology

The Commensal Microbe Veillonella as a Marker for Response to an FGF19 Analog in NASH

Rohit Loomba et al.

Summary: This study investigated the impact of aldafermin on the gut microbiota in patients with NASH. The results showed that aldafermin had a significant effect on the stability of the gut microbial community, leading to an enrichment in the rare genus Veillonella, which may be influenced by aldafermin-mediated suppression of bile acid synthesis.

HEPATOLOGY (2021)

Article Cardiac & Cardiovascular Systems

A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

Dan Ma et al.

Summary: This study utilized bibliometric analysis to identify research hotspots and trends of exosomes in cardiovascular diseases, revealing a flourishing research field with a focus on regenerative medicine, exosome engineering, delivery vehicles, and biomarkers as potential areas for future research.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Medicine, General & Internal

Open-label phase II study evaluating safety and efficacy of the non-steroidal farnesoid X receptor agonist PX-104 in non-alcoholic fatty liver disease

Stefan Traussnigg et al.

Summary: In non-diabetic NAFLD patients, the non-steroidal FXR agonist PX-104 improved insulin sensitivity and liver enzymes after 4 weeks of treatment. While hepatic steatosis and other measures did not change, alterations in fecal BAs and gut microbiota warrant further investigation.

WIENER KLINISCHE WOCHENSCHRIFT (2021)

Review Immunology

Gut microbiome, liver immunology, and liver diseases

Rui Wang et al.

Summary: The delicate interaction between the gut microbiota and liver is crucial in preventing accidental immune activation against harmless antigens, also aiding in understanding and treating various liver diseases.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Gastroenterology & Hepatology

Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial

Anat Yaskolka Meir et al.

Summary: The study found that a green-Mediterranean diet (MED) is more effective in reducing non-alcoholic fatty liver disease (NAFLD), with a greater decrease in intrahepatic fat (IHF) content, by further restricting red/processed meat and increasing intake of green plants and polyphenols. This healthy dietary strategy shows promising results in reducing IHF and decreasing NAFLD prevalence.
Review Gastroenterology & Hepatology

The complex link between NAFLD and type 2 diabetes mellitus - mechanisms and treatments

Giovanni Targher et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) have a complex relationship with each other, influencing the risk of adverse clinical outcomes. The severity of NAFLD is directly related to the risk of developing T2DM, while improvement of NAFLD may lower the risk of T2DM.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Endocrinology & Metabolism

A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage

Suling Huang et al.

Summary: This study reveals that OCA inhibits NLRP3 inflammasome activation in BMDMs by impacting the activation stage and disrupting ASC oligomerization, leading to potential therapeutic effects on NASH. The findings were validated in murine models and in vitro experiments.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

Article Endocrinology & Metabolism

Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease

Shumin Zhang et al.

Summary: This review summarizes the crosstalk between short chain fatty acids (SCFAs) and host metabolism in relation to NAFLD pathophysiology, focusing on recent advances. It highlights the roles of SCFAs in gut generation and absorption, maintenance of gut barrier, alleviation of hepatic inflammatory responses, and regulation of hepatic energy balance, with involvement of G-protein-coupled receptors (GPRs) in these metabolic processes. The review aims to provide new insights into the potential therapeutic targeting of SCFAs in the management of liver diseases.

OBESITY REVIEWS (2021)

Article Nutrition & Dietetics

The Effect of Probiotics (MCP(R) BCMC(R) Strains) on Hepatic Steatosis, Small Intestinal Mucosal Immune Function, and Intestinal Barrier in Patients with Non-Alcoholic Fatty Liver Disease

Mohamad Hizami Mohamad Nor et al.

Summary: The use of probiotics did not lead to significant clinical improvement in NAFLD patients in terms of hepatic steatosis and fibrosis levels, but at the microenvironment level, probiotics seemed to stabilize mucosal immune function and protect patients against increased intestinal permeability. Further studies with larger sample sizes and different probiotic strains are needed to evaluate the true benefit of probiotics in NAFLD.

NUTRIENTS (2021)

Review Gastroenterology & Hepatology

The gut-liver axis in liver disease: Pathophysiological basis for therapy

Agustin Albillos et al.

JOURNAL OF HEPATOLOGY (2020)

Review Pharmacology & Pharmacy

The gut-liver-kidney axis: Novel regulator of fatty liver associated chronic kidney disease

Desh Raj et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Multidisciplinary Sciences

Targeting glutamine metabolism slows soft tissue sarcoma growth

Pearl Lee et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

The Molecular and Mechanistic Insights Based on Gut-Liver Axis: Nutritional Target for Non-Alcoholic Fatty Liver Disease (NAFLD) Improvement

Yun Ji et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Medicine, General & Internal

Nonalcoholic Steatohepatitis: A Review

Adam C. Sheka et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Immunology

The intestinal microbiota fuelling metabolic inflammation

Herbert Tilg et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Gastroenterology & Hepatology

Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease

Marco Biolato et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2019)

Article Gastroenterology & Hepatology

Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

Juliette Mouries et al.

JOURNAL OF HEPATOLOGY (2019)

Article Medicine, Research & Experimental

Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression

Xiaoqing Huang et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Cell Biology

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

Jing Yuan et al.

CELL METABOLISM (2019)

Review Endocrinology & Metabolism

Gut microbial metabolites in obesity, NAFLD and T2DM

Emanuel E. Canfora et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Review Biochemistry & Molecular Biology

The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD)

Zahra Safari et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Review Gastroenterology & Hepatology

Lipotoxicity and the gut-liver axis in NASH pathogenesis

Fabio Marra et al.

JOURNAL OF HEPATOLOGY (2018)

Review Biochemistry & Molecular Biology

Mechanisms of NAFLD development and therapeutic strategies

Scott L. Friedman et al.

NATURE MEDICINE (2018)

Review Gastroenterology & Hepatology

The gut-liver axis and the intersection with the microbiome

Anupriya Tripathi et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

Rifaximin in nonalcoholic fatty liver disease: hit multiple targets with a single shot

Ahmed Abdel-Razik et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2018)

Review Gastroenterology & Hepatology

NAFLD and diabetes mellitus

Herbert Tilg et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Review Urology & Nephrology

Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease

Giovanni Targher et al.

NATURE REVIEWS NEPHROLOGY (2017)

Review Nutrition & Dietetics

Animal Models of Nonalcoholic Fatty Liver Disease-A Starter's Guide

Mikhail A. Van Herck et al.

NUTRIENTS (2017)

Article Gastroenterology & Hepatology

Pathophysiology of Nonalcoholic Fatty Liver Disease: Lifestyle-Gut-Gene Interaction

Arianna Mazzotti et al.

DIGESTIVE DISEASES (2016)

Article Endocrinology & Metabolism

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Elena Buzzetti et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

Review Pharmacology & Pharmacy

Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis

Sathish Sivaprakasam et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Article Gastroenterology & Hepatology

Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease

Venkatanarayana Gangarapu et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2015)

Article Gastroenterology & Hepatology

Intestinal Microbiota in Patients With Nonalcoholic Fatty Liver Disease

Marialena Mouzaki et al.

HEPATOLOGY (2013)

Article Multidisciplinary Sciences

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Jorge Henao-Mejia et al.

NATURE (2012)

Article Gastroenterology & Hepatology

Novel Evidence for Chronic Exposure to Endotoxin in Human Nonalcoholic Steatohepatitis

Froukje J. Verdam et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2011)

Article Gastroenterology & Hepatology

Antibiotics protect against fructose-induced hepatic lipid accumulation in mice:: Role of endotoxin

Ina Bergheim et al.

JOURNAL OF HEPATOLOGY (2008)

Article Multidisciplinary Sciences

An obesity-associated gut microbiome with increased capacity for energy harvest

Peter J. Turnbaugh et al.

NATURE (2006)

Article Computer Science, Information Systems

CiteSpace II: Detecting and visualizing emerging trends and transient patterns in scientific literature

CM Chen

JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY (2006)

Article Multidisciplinary Sciences

Searching for intellectual turning points: Progressive knowledge domain visualization

CM Chen

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)