4.7 Review

Choline supplements: An update

Journal

FRONTIERS IN ENDOCRINOLOGY
Volume 14, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2023.1148166

Keywords

choline; choline alfoscerate; choline bitartrate; choline supplementation; cognitive dysfunction; GPC; lecithin; supplements

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This comprehensive review examines the effects of various choline supplements, such as choline alfoscerate, choline bitartrate, lecithin, and citicoline, on cognitive function. These supplements have been extensively used as food supplements and have shown to be effective in enhancing memory and cognitive function.
In this comprehensive review, we examine the main preclinical and clinical investigations assessing the effects of different forms of choline supplementation currently available, including choline alfoscerate (C8H20NO6P), also known as alpha-glycerophosphocholine (alpha-GPC, or GPC), choline bitartrate, lecithin, and citicoline, which are cholinergic compounds and precursors of acetylcholine. Extensively used as food supplements, they have been shown to represent an effective strategy for boosting memory and enhancing cognitive function.

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