How to maximize the therapeutic effect of exosomes on skin wounds in diabetes mellitus: Review and discussion

Chronic skin wound healing, especially in diabetes mellitus, is still unsolved. Although many efforts have been made to treat diabetic skin wounds, current strategies have achieved limited effectiveness. Nowadays, a great number of studies have shown that exosomes might be a promising approach for treating diabetic wounds. Many studies and reviews have focused on investigating and discussing the effectiveness and mechanism of exosomes. However, maximizing its value in treating skin wounds in diabetes mellitus requires further consideration. In this review, we reviewed and discussed the aspects that could be further improved in this process, including finding a better source of exosomes, engineering exosomes, adjusting dosage and frequency, and combining more efficient delivery methods. This review provided an overview and idea of what we can do to improve the therapeutic effect of exosomes on skin wounds in diabetes mellitus. Only by combining all the factors that affect the effectiveness of exosomes in diabetic wound healing can we further promote their clinical usefulness.

Automated summary

Chronic skin wound healing, particularly in diabetes mellitus, remains unresolved despite numerous efforts. Exosomes have emerged as a promising approach for treating diabetic wounds, but their therapeutic potential requires further enhancement. This review highlights the areas that can be improved in utilizing exosomes, including sourcing, engineering, dosage, frequency, and delivery methods.