Association between Bisphenol A exposure and body composition parameters in children

BackgroundAlthough there is evidence linking Bisphenol A (BPA) exposure to obesity, research examining its relationship with body composition parameters in young children is limited. MethodsA cross-sectional investigation was conducted on 200 preschool children aged between 4 and 6 years in Guangzhou, China. BPA exposure was assessed through urine samples using ultra-high performance liquid chromatography- tandem mass spectrometry, and body composition parameters were measured through bioelectrical impedance analysis (InBody770). ResultsThe median urinary BPA concentration was 0.556 mu g/L (IQR: 0.301 - 1.031 mu g/L) and creatinine-adjusted BPA concentration was 0.930 mu g/g (IQR: 0.551 - 1.586 mu g/g). BPA levels were significantly associated with body mass index (beta= 1.15; 95%CI: 0.47, 1.83), body fat mass (beta= 1.14; 95%CI: 0.39, 1.89), fat free mass (beta= 0.92; 95%CI: 0.26, 1.58), and percent body fat (beta= 3.44; 95%CI: 1.17, 5.71) after adjusting for potential confounding factors. Similarly, adjusted models with log(10)-transformed creatinine-adjusted BPA concentrations as a continuous variable showed similar trends. Positive linear associations were observed between quartiles of BPA concentrations and body composition parameters, with the highest coefficients in the fourth quartile. ConclusionOur study provides further evidence of positive correlations between BPA exposure and body composition parameters in children aged 4 to 6 years. These findings highlight the potential health risks associated with obesity-related body composition parameters in young children. Further investigations are needed to confirm this association and explore the underlying mechanisms.

Automated summary

A cross-sectional investigation conducted in Guangzhou, China, reveals that there is a positive correlation between Bisphenol A (BPA) exposure and body composition parameters in children aged 4 to 6 years, providing further evidence for this association.