Journal
LANGMUIR
Volume 32, Issue 40, Pages 10253-10258Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.6b02248
Keywords
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Funding
- National Natural Science Foundation of China [91333105, 21321001]
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Graphene oxide (GO) is a reliable and multifunctional platform to perform cell imaging. In this work, a controllable Pt-seed-mediated method is used to prepare GO/gold nanoparticle (AuNP) hybrids, and after the covalent binding of folic acid (FA), GO/AuNP/FA hybrids are prepared. Selective labeling and Raman imaging of folate receptor (FR)-positive HeLa cells are realized using such GO based hybrids. In this system, FA is the targeting agent, AuNPs work as surface-enhanced Raman scattering substrates, and GO takes the role of both supporting the AuNPs with FA and acting as a Raman probe. This research further extends the application of GO as a multifunctional platform in bioimaging and other biomedical processes.
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