A Rare Case of Biliary Cryptococcosis Clinical Pharmacist Participation in Treatment and Pharmaceutical Care and Literature Review

Biliary cryptococcosis infection is extremely rare and difficult for preoperative diagnosis. We report a rare case of 61-year -old woman with biliary cryptococcal infection. To explore the general rule and case characteristics of biliary cryptococcal infection and provide a reference for future diagnosis and treatment, we consulted the PubMed database for reported biliary cryptococcal infection from 1985 to 2021. Including the present one, we collected 12 reports, among which half were male and five were younger than 18 years old. Clinical manifestations were mainly jaundice, while in vitro examination revealed bile duct dilatation and bile duct stenosis. In 8 cases (66.67%), symptoms improved or healed after antifungal treatment. Although preoperative misdiagnosis of cryptococcal infection is high, the antifungal treatment is quite effective. Thus, early accurate diagnosis can effectively improve the cure rate of biliary cryptococcosis infected patients.

Automated summary

Biliary cryptococcal infection is rare and difficult to diagnose preoperatively. This case report and literature review collected a total of 12 reports of biliary cryptococcal infection from 1985 to 2021. Clinical manifestations were mainly jaundice, with bile duct dilatation and stenosis observed in vitro. Treatment with antifungal drugs resulted in symptom improvement or recovery in 66.67% of the cases. Early and accurate diagnosis is crucial for improving the cure rate of biliary cryptococcosis infected patients.