Identification and verification of ferroptosis-related genes in gastric intestinal metaplasia

Article Oncology

IL-17A promotes Helicobacter pylori-induced gastric carcinogenesis via interactions with IL-17RC

Jee Hyun Kang et al.

Summary: IL-17A promotes gastric carcinogenesis, potentially through the regulation of the IL-17RC/NF-κB/NOX1 pathway. This finding provides a new target for the treatment of gastric cancer.

GASTRIC CANCER (2023)

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Review Gastroenterology & Hepatology

Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond

James R. Goldenring et al.

Summary: The mucosa of the body of the stomach uses depth-dependent mechanisms to respond to injury, leading to various histopathological changes and potential progression to dysplasia and cancer. This metaplasia process is broadly conserved across tissues and species, involving specific cytokines in facilitating the reprogramming of cells into different types, with implications for diagnostic and clinical purposes.

GASTROENTEROLOGY (2022)

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Article Cell Biology

Ferritinophagy-Mediated Ferroptosis and Activation of Keap1/Nrf2/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2,2'-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester

Deng Guan et al.

Summary: Research revealed that DpdtbA resisted TGF-beta 1-induced EMT through ferritinophagy-mediated ROS production, promoting EMT inhibition. Additionally, activation of Nrf2 played a role in regulating the cellular redox environment changes.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Gastroenterology & Hepatology

Induction and Regulation of the Innate Immune Response in Helicobacter pylori Infection

Alain P. Gobert et al.

Summary: Gastric cancer is the fifth most common cancer and the fourth most common cause of cancer-related death worldwide. The key factor in the development of gastric inflammation and disease progression is Helicobacter pylori infection, although only a small percentage of infected individuals develop gastric adenocarcinoma.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Review Pharmacology & Pharmacy

Role of ferroptosis and ferroptosis-related non-coding RNAs in the occurrence and development of gastric cancer

Ling Lu et al.

Summary: This article summarizes the roles and functions of ferroptosis and ferroptosis-related ncRNAs in the tumorigenesis, development, and prognosis of gastric cancer (GC) and prospects the future research direction and challenges.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Cell Biology

Ferroptosis and its Role in Gastric Cancer

Renjun Gu et al.

Summary: Gastric cancer is a common type of cancer with surgery as the main treatment method. However, it is expensive and painful, and patients often experience recurrence. Ferroptosis, a form of cell death dependent on iron, provides a new perspective in cancer therapy. This review summarizes the latest findings on ferroptosis regulation in gastric cancer, discusses the potential of drugs and genes in inducing ferroptosis for treatment and drug resistance, explores the relationship between ferroptosis and the tumor microenvironment in gastric cancer, and suggests areas for future research to accelerate the clinical utility of ferroptosis induction as a treatment strategy for gastric cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Signaling pathways and therapeutic interventions in gastric cancer

Zi-Ning Lei et al.

Summary: Gastric cancer is the fifth most diagnosed cancer and the fourth leading cause of cancer-related death worldwide. Advancements in genome analysis have identified biomarkers and signaling pathways that play vital roles in gastric cancer development, progression, and treatment response. These discoveries provide a direction for improving gastric cancer diagnosis and treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Pharmacology & Pharmacy

Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage

Dominik Bakalarz et al.

Summary: Metal-based carbon monoxide (CO)-releasing molecules have shown anti-inflammatory and anti-oxidative properties in maintaining gastric mucosal integrity. This study investigates the protective effects of a metal-free CO-based therapeutic, BW-CO-111, in rat models of gastric damage induced by necrotic ethanol or aspirin. Results suggest that BW-CO-111 could increase gastric mucosal CO content, reduce gastric lesions area, and improve gastric blood flow, with potential different mechanisms based on the specific pathomechanisms in each model.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Apatinib induced ferroptosis by lipid peroxidation in gastric cancer

Liying Zhao et al.

Summary: In summary, apatinib induces lipid peroxidation through GPX4 mediated by SREBP-1a, leading to the ferroptosis of gastric cancer cells, including multi-drug resistant ones.

GASTRIC CANCER (2021)

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Article Cell Biology

Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer

Yanfei Shao et al.

Summary: The study constructed a prognostic signature of 10 ferroptosis-related genes, which effectively predict the survival rate and immunotherapy response of gastric cancer patients. By screening differentially expressed genes and dividing patients into high-risk and low-risk groups based on risk scores, it was found that patients in the low-risk group had better survival possibilities.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Pharmacology & Pharmacy

Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer

Ying Liu et al.

Summary: The new JDA derivative a2 was found to inhibit the growth of gastric cancer cells and induce ferroptosis. Through the autophagy pathway, a2 caused ferrous iron accumulation, and prevention of this process alleviated a2-induced elevation of ferrous iron and cell growth inhibition, demonstrating stronger anti-cancer activity in gastric cancer xenograft models compared to 5-fluorouracil.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Biochemistry & Molecular Biology

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis

Shuo Ni et al.

Summary: This study demonstrates the involvement of ferroptosis in osteoclast differentiation induced by RANKL, with mechanisms including iron-starvation response and ferritinophagy. It also reveals the impact of HIF-1 alpha on ferritinophagy and autophagy flux under hypoxia conditions. Ferroptosis induction in osteoclasts through targeting HIF-1 alpha and ferritin may offer a novel therapeutic approach for osteoporosis.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Oncology