☆ 4.6 Article

Identification of a cellular senescence-related-lncRNA (SRlncRNA) signature to predict the overall survival of glioma patients and the tumor immune microenvironment

FRONTIERS IN GENETICS (2023)

Related references

Note: Only part of the references are listed.

Article Cell Biology

A 1p/19q Codeletion-Associated Immune Signature for Predicting Lower Grade Glioma Prognosis

Jie Xu et al.

Summary: This study established an immune signature associated with 1p/19q chromosomal codeletion in lower grade gliomas (LGGs) for accurate prediction of prognosis. The prognostic signature was validated in training and testing groups, and immune checkpoints correlated with the risk score were identified.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)

Add to Collection

Review Biochemical Research Methods

Tumor immune microenvironment lncRNAs

Eun-Gyeong Park et al.

Summary: This review discusses the specific expression of long non-coding ribonucleic acids (lncRNAs) in tumor and immune cells, summarizes their regulatory functions at the cell type level, and highlights the application of single-cell RNA-sequencing (scRNA-seq) in studying the cell type-specific functions of lncRNAs in the tumor immune microenvironment (TIME).

BRIEFINGS IN BIOINFORMATICS (2022)

Add to Collection

Review Cardiac & Cardiovascular Systems

The role of cellular senescence in cardiac disease: basic biology and clinical relevance

Mozhdeh Mehdizadeh et al.

Summary: This review discusses the role of cellular senescence in cardiac disease, outlines therapeutic strategies for targeting senescence, and considers potential implications for improving the management of patients with heart disease. The complex senescence-associated secretory phenotype (SASP) of senescent cells has important effects on cell and tissue biology. Future research is needed to better understand the precise role of senescent cells in various cardiac pathologies and develop strategies for preventing their accumulation.

NATURE REVIEWS CARDIOLOGY (2022)

Add to Collection

Review Clinical Neurology

Diagnostic accuracy of 1p/19q codeletion tests in oligodendroglioma: A comprehensive meta-analysis based on a Cochrane systematic review

Sebastian Brandner et al.

Summary: Codeletion of chromosomal arms 1p and 19q, together with the mutation in isocitrate dehydrogenase 1 or 2 gene, is the molecular diagnostic criterion for oligodendroglioma. Different techniques, including FISH and PCR-based LOH, showed good sensitivity for detecting 1p/19q codeletions in glioma. NGS and SNP array had high specificity when compared to FISH. MLPA was found to be marginally more cost-effective.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors

Mingwen Mao et al.

Summary: This article reviews the roles and mechanisms of exosomal ceRNA in the diagnosis and treatment of malignant tumors.

BIOENGINEERED (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Next RNA Therapeutics: The Mine of Non-Coding

Sabrina Garbo et al.

Summary: The increasing understanding of non-coding RNAs (ncRNAs) and their functional roles has sparked great interest in the scientific community. This review summarizes the therapeutic potential of ncRNA in disease treatment and discusses the advantages and limitations of RNA therapeutics, as well as the development of targeted delivery strategies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

LncSEA: a platform for long non-coding RNA related sets and enrichment analysis

Jiaxin Chen et al.

Summary: LncSEA is a powerful platform that provides a variety of types of lncRNA sets for users, and supports lncRNA annotations and enrichment analyses.

NUCLEIC ACIDS RESEARCH (2021)

Add to Collection

Article Biochemistry & Molecular Biology

LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM

Feifei Zhang et al.

Summary: The study found that CRNDE plays a key role in gastric cancer chemotherapy by regulating autophagy and alternative splicing events.

MOLECULAR CANCER (2021)

Add to Collection

Article Biochemistry & Molecular Biology

MSC-induced lncRNA AGAP2-AS1 promotes stemness and trastuzumab resistance through regulating CPT1 expression and fatty acid oxidation in breast cancer

Jing Han et al.

Summary: Trastuzumab resistance poses a significant challenge in treating HER-2-positive breast cancer. This study reveals that MSC-induced upregulation of AGAP2-AS1 promotes stemness and trastuzumab resistance through activating FAO. AGAP2-AS1 may serve as a promising predictive biomarker and therapeutic target for these patients.

ONCOGENE (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Long non-coding RNA (lncRNA) HOXD-AS2 promotes glioblastoma cell proliferation, migration and invasion by regulating the miR-3681-5p/MALT1 signaling pathway

Xingming Zhong et al.

Summary: This study identified that lncRNA HOXD-AS2 is significantly up-regulated in GBM tissues, promoting the aggressiveness of GBM cells by affecting the miR-3681-5p/MALT1 axis. Silencing HOXD-AS2 inhibited cell proliferation, migration, invasion, and promoted apoptosis. Future research is needed to explore the mechanism by which HOXD-AS2 is upregulated in GBM cells to provide new insights for GBM treatment.

BIOENGINEERED (2021)

Add to Collection

Article Biochemistry & Molecular Biology

TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer

Umakanta Swain et al.

Summary: TENT4A plays a critical role in regulating multiple biological pathways, specifically in translesion DNA synthesis, by modulating mRNA stability and translation of DNA polymerase eta and RAD18 E3 ligase. Additionally, TENT4A indirectly regulates RAD18 through the tumor suppressor CYLD and the long non-coding antisense RNA PAXIP1-AS2, leading to dysregulation of TLS in endometrial cancer genomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Cell Biology

Antigen presentation capability and AP-1 activation accompany methotrexate-induced colon cancer cell senescence in the context of aberrant β-catenin signaling

Magdalena Dabrowska et al.

Summary: This study compared two senescent states of colon cancer cells in response to methotrexate exposure, showing upregulation of immunoproteasome subunit-coding genes and MHC-I-restricted antigen presentation as common features. Changes in NF-kappa B p65 level and AP-1-dependent transcription were observed, along with beta-catenin signaling deregulation. These findings have implications for senescence establishment and potential advantages for colon cancer treatment.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Add to Collection

Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

Add to Collection

Article Oncology

Identification of Glycolysis-Related lncRNAs and the Novel lncRNA WAC-AS1 Promotes Glycolysis and Tumor Progression in Hepatocellular Carcinoma

Xigang Xia et al.

Summary: By analyzing the TCGA database, we identified 502 lncRNAs co-expressed with glycolytic genes, with 112 showing abnormal expression in liver cancer and 40 associated with patient prognosis. We established a prognostic model with 8 lncRNAs, showing good predictive power and potential use as an independent prognostic factor. WAC-AS1 was found to play a key role in regulating glycolysis and promoting tumor proliferation in hepatocellular carcinoma.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications

Jian Cheng et al.

MOLECULAR CANCER (2020)

Add to Collection

Article Oncology

Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling

Fatouma Alimirah et al.

CANCER RESEARCH (2020)

Add to Collection

Article Oncology

Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells

Hyun Jung Hwang et al.

CANCER LETTERS (2020)

Add to Collection

Article Multidisciplinary Sciences

The integrated genomic and epigenomic landscape of brainstem glioma

Lee H. Chen et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

The Role of MicroRNAs in Bone Metabolism and Disease

Yongguang Gao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Article Cell Biology

LncRNA SNAI3-AS1 promotes PEG10-mediated proliferation and metastasis via decoying of miR-27a-3p and miR-34a-5p in hepatocellular carcinoma

Yarui Li et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Article Multidisciplinary Sciences

The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

Shiuli Agarwal et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Cell Biology

RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4

Bingqing Hui et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Article Cell Biology

Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness

Vivian Yvonne Shin et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Review Physiology

CELLULAR SENESCENCE: AGING, CANCER, AND INJURY

Arianna Calcinotto et al.

PHYSIOLOGICAL REVIEWS (2019)

Add to Collection

Article Cell Biology

Long non-coding RNA SNAI3-AS1 promotes the proliferation and metastasis of hepatocellular carcinoma by regulating the UPF1/Smad7 signalling pathway

Yarui Li et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Add to Collection

Article Cell Biology

Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma

Chenlong Li et al.

CELL DEATH & DISEASE (2019)

Add to Collection

Review Oncology

Glioma epigenetics: From subclassification to novel treatment options

Olga Gusyatiner et al.

SEMINARS IN CANCER BIOLOGY (2018)

Add to Collection

Article Medicine, Research & Experimental

Long non-coding RNA NRON is downregulated in HCC and suppresses tumour cell proliferation and metastasis

Zhicheng Yao et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Functional Classification and Experimental Dissection of Long Noncoding RNAs

Florian Kopp et al.

CELL (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Role of extracellular vesicles in glioma progression

Claudia Quezada et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

Add to Collection

Review Biochemistry & Molecular Biology

New insights into long noncoding RNAs and their roles in glioma

Zixuan Peng et al.

MOLECULAR CANCER (2018)

Add to Collection

Review Cell Biology

Hallmarks of Cellular Senescence

Alejandra Hernandez-Segura et al.

TRENDS IN CELL BIOLOGY (2018)

Add to Collection

Review Medicine, General & Internal

Primary brain tumours in adults

Sarah Lapointe et al.

LANCET (2018)

Add to Collection

Article Biochemistry & Molecular Biology

The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling

Peng Han et al.

MOLECULAR CANCER (2017)

Add to Collection

Review Biotechnology & Applied Microbiology

Glioblastoma: exosome and microRNA as novel diagnosis biomarkers

L. Saadatpour et al.

CANCER GENE THERAPY (2016)

Add to Collection

Review Oncology

Survival in glioblastoma: a review on the impact of treatment modalities

P. D. Delgado-Lopez et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2016)

Add to Collection

Review Genetics & Heredity

Unique features of long non-coding RNA biogenesis and function

Jeffrey J. Quinn et al.

NATURE REVIEWS GENETICS (2016)

Add to Collection

Article Clinical Neurology

Accurate Delineation of Glioma Infiltration by Advanced PET/MR Neuro-Imaging (FRONTIER Study): A Diagnostic Study Protocol

Niels Verburg et al.

NEUROSURGERY (2016)

Add to Collection

Review Cell Biology

Cellular senescence: from physiology to pathology

Daniel Munoz-Espin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Add to Collection

Editorial Material Oncology

Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy

Pierre Hainaut et al.

CURRENT OPINION IN ONCOLOGY (2013)

Add to Collection

Article Multidisciplinary Sciences

Embedding and Publishing Interactive, 3-Dimensional, Scientific Figures in Portable Document Format (PDF) Files

David G. Barnes et al.

PLOS ONE (2013)

Add to Collection

Article Multidisciplinary Sciences

A strategy for probing the function of noncoding RNAs finds a repressor of NFAT

AT Willingham et al.

SCIENCE (2005)

Add to Collection

Article Multidisciplinary Sciences

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

Y Okazaki et al.

NATURE (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.