The 4G/5G polymorphism of plasminogen activator inhibitor type 1 is a predictor of allergic cough

Article Gastroenterology & Hepatology

Plasminogen Activator Inhibitor-1 as a Marker of Esophageal Functional Changes in Pediatric Eosinophilic Esophagitis

Prerana Williamson et al.

Summary: The study found that PAI-1 is significantly elevated in pediatric EoE and can distinguish altered compliance in children. PAI-1 may be a novel disease marker and therapeutic target.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Pharmacology & Pharmacy

Tumor Necrosis Factor Alpha-308G/A Gene Polymorphisms Combined with Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio Predicts the Efficacy and Safety of Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis, Rheumatoid Arthritis, and Psoriasis Arthritis

Ziran Wang et al.

Summary: This study preliminarily showed that combining TNF-alpha -308G/A polymorphisms with NLR and PLR can predict the responsiveness and safety of anti-TNF therapy in patients with AS or RA.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Hematology

Clinical impact of the PAI-1 4G/5G polymorphism in Chinese patients with venous thromboembolism

Ziran Wang et al.

Summary: This study aimed to investigate the clinical impact of the PAI-1 4G/5G polymorphism in Chinese patients with VTE. The results showed no significant correlation between the PAI-1 4G/5G polymorphism and VTE susceptibility, but differences were observed in neutrophil counts, NLR, recanalization, and recurrence status based on the genotype. Additionally, PAI-1 antigen levels were higher in the VTE group compared to the control group. These findings lay the foundation for the personalized management and monitoring of VTE patients using PAI-1 4G/5G polymorphism.

THROMBOSIS JOURNAL (2022)

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Article Allergy

Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

Xingnan Li et al.

Summary: Multiple SNPs in the gasdermin B (GSDMB) gene are associated with asthma severity and longitudinal asthma exacerbations. Higher expression levels of GSDMB correlate with asthma exacerbations and pathways related to IFN signaling and immune system. GSDMB is identified as a functional gene for both asthma susceptibility and severity.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article

The blocking effect of the glycoprotein IIb/IIIa receptor in the mouse model of asthma

Seo-Hee Kim et al.

Clinical and Molecular Allergy (2021)

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Article Otorhinolaryngology

The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children

Miaomiao Zhao et al.

Summary: The study found that the polymorphism of rs321029 on the CYSLTR1 gene is not associated with the susceptibility and severity of allergic rhinitis (AR) in children, but it is closely related to the efficacy of montelukast on AR. The total montelukast effective rate of wide-type genotype TT children was significantly higher than variants genotype CC children.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2021)

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Article Immunology

The 4G/5G Polymorphism of Plasminogen Activator Inhibitor Type 1 is a Predictor of Moderate-to-Severe Thyroid Eye Disease

Monika Katko et al.

Summary: The study found that the 4G/4G genotype of PAI-1 is associated with the development of moderate-to-severe TED, while the 4G/5G polymorphism is not a predictor of plasma PAI-1 levels.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Immunology

Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization

Yifan Wu et al.

Summary: Research shows that Candida albicans activates platelets through the peptide toxin candidalysin to release the Wnt antagonist Dickkopf-1, promoting Th2 and Th17 cell responses, reducing lung fungal burdens, and preventing lethal pulmonary hemorrhage resulting from fungal lung invasion.

IMMUNITY (2021)

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Article Immunology