Journal
LANGMUIR
Volume 32, Issue 11, Pages 2659-2667Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.5b04643
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Funding
- Nova Scotia Health Research Foundation (NSHRF)
- Sydney Tar Ponds Agency
- Cape Breton University RP Program
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Institutes of Health Research (CIHR)-Canada Graduate Scholarships (CGS) research award
- Beatrice Hunter Cancer Research Institute
- Breast Cancer Society of Canada/QEII Foundation/BHCRI Traineeship for Breast Cancer Research as part of the Cancer Research Training Program
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Layered double hydroxide nanoparticles (LDH NPs) have attracted interest as an effective gene delivery vehicle in biomedicine. Recent advances in clinic trials have demonstrated the efficacy of Mg/Fe LDHs for hyperphosphatemia treatment, but their feasibility for gene delivery has not been systematically evaluated. As a starting point, we aimed to study the interaction between oligo-DNA and Mg/Fe LDH NPs. Our investigation revealed the chemisorption mechanism of DNA on Mg/Fe LDH surfaces, wherein the phosphate backbone of the DNA polymer coordinates with the metal cations of the LDH lattice via the ligand-exchange process. This mechanistic insight may facilitate future gene delivery applications using Mg/Fe LDH NPs.
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