Journal
LANGMUIR
Volume 32, Issue 11, Pages 2659-2667Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.5b04643
Keywords
-
Funding
- Nova Scotia Health Research Foundation (NSHRF)
- Sydney Tar Ponds Agency
- Cape Breton University RP Program
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Institutes of Health Research (CIHR)-Canada Graduate Scholarships (CGS) research award
- Beatrice Hunter Cancer Research Institute
- Breast Cancer Society of Canada/QEII Foundation/BHCRI Traineeship for Breast Cancer Research as part of the Cancer Research Training Program
Ask authors/readers for more resources
Layered double hydroxide nanoparticles (LDH NPs) have attracted interest as an effective gene delivery vehicle in biomedicine. Recent advances in clinic trials have demonstrated the efficacy of Mg/Fe LDHs for hyperphosphatemia treatment, but their feasibility for gene delivery has not been systematically evaluated. As a starting point, we aimed to study the interaction between oligo-DNA and Mg/Fe LDH NPs. Our investigation revealed the chemisorption mechanism of DNA on Mg/Fe LDH surfaces, wherein the phosphate backbone of the DNA polymer coordinates with the metal cations of the LDH lattice via the ligand-exchange process. This mechanistic insight may facilitate future gene delivery applications using Mg/Fe LDH NPs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
