Journal
FRONTIERS IN CHEMISTRY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2023.1140562
Keywords
quinazoline; transition-metal; catalysis; synthesis; mechanism
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Transition-metal-catalyzed reactions have been widely used in the synthesis of nitrogen-containing heterocyclic compounds called quinazolines. This review summarizes the progress and mechanistic insights of these reactions, as well as discusses their advantages, limitations, and future perspectives.
Quinazolines are a class of nitrogen-containing heterocyclic compounds with broad-spectrum of pharmacological activities. Transition-metal-catalyzed reactions have emerged as reliable and indispensable tools for the synthesis of pharmaceuticals. These reactions provide new entries into pharmaceutical ingredients of continuously increasing complexity, and catalysis with these metals has streamlined the synthesis of several marketed drugs. The last few decades have witnessed a tremendous outburst of transition-metal-catalyzed reactions for the construction of quinazoline scaffolds. In this review, the progress achieved in the synthesis of quinazolines under transition metal-catalyzed conditions are summarized and reports from 2010 to date are covered. This is presented along with the mechanistic insights of each representative methodology. The advantages, limitations, and future perspectives of synthesis of quinazolines through such reactions are also discussed.
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