Maternal Multiple Sclerosis and Health Outcomes the Children: A Review

Article Clinical Neurology

Pregnancy outcomes after early fetal exposure to injectable first-line treatments, dimethyl fumarate, or natalizumab in Danish women with multiple sclerosis

Johanna Balslev Andersen et al.

Summary: This study found no increased association of adverse pregnancy outcomes in newborns with fetal exposure to disease-modifying drugs (DMDs) when compared with either DMD-unexposed pregnancies or the general population.

EUROPEAN JOURNAL OF NEUROLOGY (2023)

Add to Collection

Article

Pregnancy Management in Multiple Sclerosis and Other Demyelinating Diseases

Riley M. Bove et al.

CONTINUUM Lifelong Learning in Neurology (2022)

Add to Collection

Article Clinical Neurology

Pregnancy in women with multiple sclerosis in France from 2010 to 2015: Incidence, outcomes, and exposure to disease-modifying therapies

Helene Tillaut et al.

Summary: The pregnancy incidence rate for women with multiple sclerosis was approximately 4.5 per 100 person-years. The probability of having a pregnancy exposed to disease-modifying therapies increased over time, with those who stopped treatment within the previous year having the highest probability of live birth.

MULTIPLE SCLEROSIS JOURNAL (2022)

Add to Collection

Article Clinical Neurology

Pregnancy outcomes following maternal or paternal exposure to teriflunomide in the Danish MS population

Johanna Balslev Andersen et al.

Summary: The study investigated the association of adverse perinatal outcomes in newborns with maternal or paternal exposure to teriflunomide, and found no increased prevalence of spontaneous abortion, preterm birth, congenital malformations, low Apgar score, or being small for gestational age in newborns with exposure to teriflunomide compared to the general population.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Add to Collection

Article Clinical Neurology

Fertility preferences and unmet need for family planning in women with multiple sclerosis

Lorena Lopez-Reyes et al.

Summary: Fertility preferences in women with MS are not influenced by clinical variables, and a significant number of women choose not to have children and prefer permanent contraceptive methods. Although the frequency of contraceptive use is high, some women have an unmet need for family planning and use low-efficacy contraceptive methods, which may result in unplanned pregnancies.

FRONTIERS IN NEUROLOGY (2022)

Add to Collection

Review Pediatrics

Maternal Multiple Sclerosis and Offspring's Cognitive and Behavioral Development: What Do We Know until Now?

Martina Siracusano et al.

Summary: This article provides an overview of the available literature on the influence of maternal Multiple Sclerosis on offspring cognitive and behavioral development. The existing studies have low methodological quality and do not lead to conclusive findings. Further longitudinal studies should consider maternal confounding factors and the exposure to pharmacological treatment during pregnancy.

CHILDREN-BASEL (2022)

Add to Collection

Article Clinical Neurology

Fetal and post-natal growth in infants of mothers with multiple sclerosis: A case-control stud

Luca Marozio et al.

Summary: Multiple sclerosis does not appear to affect fetal growth and postnatal development during the first year of the offspring's life, providing important and reassuring information for patients during preconception counseling.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Add to Collection

Article Public, Environmental & Occupational Health

Time trends of chronic immune diseases by year of birth in Danish registries

Astrid Sevelsted et al.

Summary: The study found that in recent 35 years, hospitalizations for adult asthma, juvenile arthritis, inflammatory bowel diseases, and multiple sclerosis showed a general increasing trend by birth year, while type 1 diabetes and childhood asthma seemed stable during this period. The nationwide introduction of measles, mumps, rubella vaccine in 1987 did not alter these trends.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2021)

Add to Collection

Review Clinical Neurology

Apparent changes in the epidemiology and severity of multiple sclerosis

Nils Koch-Henriksen et al.

Summary: The incidence of MS appears to be increasing, but the disease has become milder. Understanding these trends and the reasons behind them is crucial for clinical management and treatment decisions.

NATURE REVIEWS NEUROLOGY (2021)

Add to Collection

Article Pediatrics

Maternal Chronic Conditions and Risk of Cerebral Palsy in Offspring: A National Cohort Study

Marianne S. Strom et al.

Summary: The study found that mothers with autoimmune disorders during pregnancy were associated with an increased risk of cerebral palsy in offspring, while no increased risk was seen for offspring of fathers with chronic conditions.

PEDIATRICS (2021)

Add to Collection

Article Clinical Neurology

Pregnancy outcomes in women with Multiple Sclerosis

Bernardita Soler et al.

Summary: This study investigated pregnancy decision-making and outcomes in women with multiple sclerosis (MS) before and after diagnosis. The results showed that after MS diagnosis, women tend to have fewer children at an older age, with a higher rate of cesarean sections. However, there were no significant differences in newborn outcomes between the two groups.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection

Article Clinical Neurology

Prevalence of adverse pregnancy outcomes after exposure to interferon beta prior to or during pregnancy in women with MS: Stratification by maternal and newborn characteristics in a register-based cohort study in Finland and Sweden

Marta Korjagina et al.

Summary: This study aimed to describe the prevalence of adverse pregnancy outcomes among women with multiple sclerosis exposed to interferon-beta compared to those unexposed to any MS disease modifying drugs, and found that the prevalence of serious adverse pregnancy outcomes did not significantly differ between the two groups across various characteristics.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2021)

Add to Collection

Review Medicine, General & Internal

How well can we assess the validity of non-randomised studies of medications? A systematic review of assessment tools

Elvira D'Andrea et al.

Summary: This study systematically reviewed 44 assessment tools for non-randomised studies (NRS) and found that most tools do not adequately address critical elements influencing the validity of NRS findings for the comparative safety and effectiveness of medications. The study suggests that future research should integrate these critical elements into the assessment methods.

BMJ OPEN (2021)

Add to Collection

Review Clinical Neurology

Influence of Pregnancy in Multiple Sclerosis and Impact of Disease-Modifying Therapies

Isabella Laura Simone et al.

Summary: Multiple sclerosis predominantly affects young women, impacting fertility, pregnancy, fetal outcome, and breastfeeding. The use of disease-modifying therapies has changed the natural history of the disease and perspectives on pregnancy.

FRONTIERS IN NEUROLOGY (2021)

Add to Collection

Article Clinical Neurology

Pregnancy-Related and Perinatal Outcomes in Women With Multiple Sclerosis A Nationwide Danish Cross-sectional Study

Johanna Balslev Andersen et al.

Summary: This study investigated differences in pregnancy-related and perinatal outcomes between women with multiple sclerosis (MS) and the general population. Results showed a higher prevalence of elective c-sections, induced delivery, and infants being small for gestational age (SGA) among newborns to women with MS, while a lower prevalence of signs indicating asphyxia was found in the study cohort. There were no significant differences in severe adverse perinatal outcomes between women with MS and the general population.

NEUROLOGY-CLINICAL PRACTICE (2021)

Add to Collection

Article Clinical Neurology

Reproductive history of the Danish multiple sclerosis population: A register-based study

Julie Yoon Moberg et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Add to Collection

Article Obstetrics & Gynecology

Live birth in women with multiple sclerosis receiving assisted reproduction

Line Riis Jolving et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2020)

Add to Collection

Review Clinical Neurology

A systematic review and meta-analyses of pregnancy and fetal outcomes in women with multiple sclerosis: a contribution from the IMI2 ConcePTION project

Joan K. Morris et al.

JOURNAL OF NEUROLOGY (2020)

Add to Collection

Article Public, Environmental & Occupational Health

Pregnancy Outcomes in Women With Multiple Sclerosis

Sarah C. MacDonald et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2019)

Add to Collection

Article Public, Environmental & Occupational Health

Use and safety of disease-modifying therapy in pregnant women with multiple sclerosis

Sarah C. MacDonald et al.

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2019)

Add to Collection

Review Clinical Neurology

Management strategies for female patients of reproductive potential with multiple sclerosis: An evidence-based review

Patricia K. Coyle et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Add to Collection

Article Obstetrics & Gynecology

Multiple sclerosis in pregnancy: prevalence, sociodemographic features, and obstetrical outcomes

Alex Fong et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2018)

Add to Collection

Article Clinical Neurology

Pregnancy decision-making in women with multiple sclerosis treated with natalizumab: I: Fetal risks

Emilio Portaccio et al.

NEUROLOGY (2018)

Add to Collection

Article Behavioral Sciences

Mental health among children of mothers with multiple sclerosis: A Danish cohort and register-based study

Johanna Balslev Andersen et al.

BRAIN AND BEHAVIOR (2018)

Add to Collection

Article Clinical Neurology

Perinatal characteristics and obstetric complications in mothers with multiple sclerosis: Record-linkage study

Alexander Goldacre et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2017)

Add to Collection

Article Clinical Neurology

Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk

Zongqi Xia et al.

ANNALS OF NEUROLOGY (2016)

Add to Collection

Article Clinical Neurology

Educational achievements of children of parents with multiple sclerosis: A nationwide register-based cohort study

J. Y. Moberg et al.

JOURNAL OF NEUROLOGY (2016)

Add to Collection

Article Clinical Neurology

Children of chronically ill parents: Relationship between parental multiple sclerosis and childhood developmental health

Neda Razaz et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Add to Collection

Article Clinical Neurology

Glatiramer acetate during early pregnancy: A prospective cohort study

Sandra Herbstritt et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Add to Collection

Article Clinical Neurology

Interferon-beta exposure during first trimester is safe in women with multiple sclerosisA prospective cohort study from the German Multiple Sclerosis and Pregnancy Registry

Sandra Thiel et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Add to Collection

Article Public, Environmental & Occupational Health

Incidence of Mood or Anxiety Disorders in Children of Parents with Multiple Sclerosis

Neda Razaz et al.

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY (2016)

Add to Collection

Article Clinical Neurology

Children of chronically ill parents: Relationship between parental multiple sclerosis and childhood developmental health

Neda Razaz et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Add to Collection

Article Clinical Neurology

Glatiramer acetate during early pregnancy: A prospective cohort study

Sandra Herbstritt et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Add to Collection

Article Clinical Neurology

Interferon-beta exposure during first trimester is safe in women with multiple sclerosisA prospective cohort study from the German Multiple Sclerosis and Pregnancy Registry

Sandra Thiel et al.

MULTIPLE SCLEROSIS JOURNAL (2016)

Add to Collection

Review Public, Environmental & Occupational Health

Modelling Genetic Susceptibility to Multiple Sclerosis with Family Data

Cullen O'Gorman et al.

NEUROEPIDEMIOLOGY (2013)

Add to Collection

Article Clinical Neurology

Pregnancy and fetal outcomes after interferon-β exposure in multiple sclerosis

M. P. Amato et al.

NEUROLOGY (2010)

Add to Collection

Article Clinical Neurology

Does multiple sclerosis increase risk of adverse pregnancy outcomes? A population-based study

Y. H. Chen et al.

MULTIPLE SCLEROSIS JOURNAL (2009)

Add to Collection

Article Clinical Neurology

Multiple sclerosis, immunomodulators, and pregnancy outcome: a prospective observational study

C. Weber-Schoendorfer et al.

MULTIPLE SCLEROSIS JOURNAL (2009)

Add to Collection

Article Clinical Neurology

Pregnancy, delivery and birth outcome in different stages of maternal multiple sclerosis

Julie Dahl et al.

JOURNAL OF NEUROLOGY (2008)

Add to Collection

Article Medicine, General & Internal

The origins of the developmental origins theory

D. J. P. Barker

JOURNAL OF INTERNAL MEDICINE (2007)

Add to Collection

Article Psychology, Developmental

Emotional and behavioural difficulties in children of parents with multiple sclerosis - A controlled study in Greece

Stavroula Diareme et al.

EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (2006)

Add to Collection

Article Clinical Neurology

Pregnancy, delivery, and birth outcome in women with multiple sclerosis

J Dahl et al.

NEUROLOGY (2005)

Add to Collection

Review Medicine, General & Internal

Multiple sclerosis

A Compston et al.

LANCET (2002)

Add to Collection

Article Obstetrics & Gynecology

Birth outcomes and need for hospitalization after delivery among women with multiple sclerosis

BA Mueller et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2002)

Add to Collection

Article Clinical Neurology

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis

WI McDonald et al.

ANNALS OF NEUROLOGY (2001)

Add to Collection

Maternal Multiple Sclerosis and Health Outcomes the Children: A Review

Related references

Export Citation

Share Paper