Journal
LANGMUIR
Volume 32, Issue 34, Pages 8743-8747Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.5b04755
Keywords
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Funding
- Leona M. and Harry B. Helmsley Charitable trust [2014PG-T1D002]
- Juvenile Diabetes Research Foundation [3-2011-310, 3-2013-144]
- National Institutes of Health (National Institute of Diabetes and Digestive and Kidney Diseases) through Ruth L. Kirschstein National Research Service Award [F32DK101335]
- A*STAR Predoctoral National Science Scholarship
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Injectable hydrogels have been widely used for a number of biomedical applications. Here, we report a new strategy to form an injectable and glucose-responsive hydrogel using the boronic acid glucose complexation. The ratio of boronic acid and glucose functional groups is critical for hydrogel formation. In our system, polymers with 10-60% boronic acid, with the balance being glucose-modified, are favorable to form hydrogels. These hydrogels are shear thinning and self-healing, recovering from shear-induced flow to a gel state within seconds. More importantly, these polymers displayed glucose-responsive release of an encapsulated model drug. The hydrogel reported here is an injectable and glucose responsive hydrogel constructed from the complexation of boronic acid and glucose within a single component polymeric material.
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