4.6 Article

Post-COVID interstitial lung disease in symptomatic patients after COVID-19 disease

Related references

Note: Only part of the references are listed.
Article Critical Care Medicine

Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

Ganesh Raghu et al.

Summary: This article provides updates on the guidelines for idiopathic pulmonary fibrosis (IPF) and addresses the progression of pulmonary fibrosis in patients with interstitial lung diseases (ILDs) other than IPF. The recommendations are based on consensus and systematic reviews, aiming to provide evidence-based guidance for clinicians.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Follow-Up CT Patterns of Residual Lung Abnormalities in Severe COVID-19 Pneumonia Survivors: A Multicenter Retrospective Study

Giulia Besutti et al.

Summary: This study evaluated residual chest CT abnormalities in severe COVID-19 pneumonia survivors. Results showed that over 55% of patients had normal or barely normal follow-up CT scans, while non-fibrotic and fibrotic abnormalities were found in around 37.5% and 4.4% of patients respectively. Ground-glass opacities were the most common finding in non-fibrotic changes, while subpleural reticulation and traction bronchiectasis were frequent in fibrotic abnormalities. Residual abnormalities extension decreased over time in patients with multiple timepoints available.

TOMOGRAPHY (2022)

Article Respiratory System

Dyspnoea, lung function and CT findings 3 months after hospital admission for COVID-19

Tori Vigeland Lerum et al.

Summary: The long-term pulmonary outcomes of COVID-19 after 3 months of hospital admission include chest CT opacities and reduced diffusing capacity in one-fourth of the participants. ICU patients did not show significant differences in dyspnoea scores and lung function, but had a higher prevalence of abnormal chest CT findings.

EUROPEAN RESPIRATORY JOURNAL (2021)

Article Respiratory System

Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial

Thomas Sonnweber et al.

Summary: A study found that some COVID-19 patients still experienced persistent symptoms and lung function impairment 100 days after the onset of the disease, but there was significant improvement in symptoms and cardiopulmonary status over time.

EUROPEAN RESPIRATORY JOURNAL (2021)

Article Respiratory System

Pulmonary function and radiological features 4 months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study

Sabina A. Guler et al.

Summary: The Swiss COVID-19 lung study investigated pulmonary sequelae of COVID-19 in 113 survivors. Severe/critical COVID-19 was associated with significant functional and radiological abnormalities 4 months after infection, potentially due to small-airway and lung parenchymal disease. Systematic follow-up for survivors needs to be evaluated to optimize care for patients recovering from COVID-19.

EUROPEAN RESPIRATORY JOURNAL (2021)

Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

Article Medicine, General & Internal

Follow-Up Study of the Chest CT Characteristics of COVID-19 Survivors Seven Months After Recovery

Mengqi Liu et al.

Summary: Most COVID-19 patients can absorb chest CT lesions without sequelae, but older patients with severe conditions are more likely to develop fibrosis, potentially leading to cardiopulmonary insufficiency. The combined clinical-radiological model may help predict the early formation of pulmonary fibrosis.

FRONTIERS IN MEDICINE (2021)

Article Respiratory System

Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length

Claire F. McGroder et al.

Summary: Patients who underwent mechanical ventilation for severe COVID-19 are more likely to develop fibrotic-like radiographic abnormalities after hospitalisation. The severity of initial illness, duration of mechanical ventilation, lactate dehydrogenase on admission, and leucocyte telomere length are independent risk factors for these abnormalities, which are correlated with lung function, cough, and frailty measures, but not with dyspnoea.

THORAX (2021)

Review Immunology

COVID-19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts

Alison E. John et al.

Summary: The COVID-19 pandemic started in late 2019 in Wuhan City, China and has since spread worldwide. The disease, caused by the novel SARS-CoV-2 virus, primarily affects the respiratory system but can also impact other bodily systems. Patients may develop features of interstitial pulmonary fibrosis, raising questions about the long-term effects and progression of the disease.

IMMUNOLOGICAL REVIEWS (2021)

Article Medicine, General & Internal

Usual interstitial pneumonia is the most common finding in surgical lung biopsies from patients with persistent interstitial lung disease following infection with SARS-CoV-2

Kristine E. Konopka et al.

Summary: The study investigated surgical lung biopsy results of patients with post-COVID-19 interstitial lung disease (ILD), finding that usual interstitial pneumonia (UIP) was the most common pathological finding. Patients with UIP tended to be older and with pre-existing lung disease before COVID-19, with CT changes potentially helpful in identifying underlying fibrotic chronic interstitial pneumonia.

ECLINICALMEDICINE (2021)

Review Respiratory System

Lung function and breathing patterns in hospitalised COVID-19 survivors: a review of post-COVID-19 Clinics

James A. Stockley et al.

Summary: There is limited research on the effects of COVID-19 on respiratory physiology, particularly breathing patterns. This study found evidence of pulmonary restriction in 65.4% of all patients, with abnormal breathing patterns observed in 18.8% of subjects, suggesting an extrapulmonary cause. The effects on lung function appear to be similar in COVID-19 survivors whether or not they received mechanical ventilation.

RESPIRATORY RESEARCH (2021)

Article Respiratory System

Persistent Post-COVID-19 Interstitial Lung Disease An Observational Study of Corticosteroid Treatment

Katherine Jane Myall et al.

Summary: Following SARS-CoV-2 infection, some patients develop persistent radiological inflammatory lung disease and functional deficits. Early treatment with corticosteroids is well tolerated and associated with rapid and significant improvement.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2021)

Article Respiratory System

'Long-COVID': a cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19

Swapna Mandal et al.

Summary: Following discharge from hospital, a significant number of COVID-19 patients continue to experience persistent symptoms such as breathlessness, cough, fatigue, and depression. Some patients also show elevated levels of biomarkers indicating ongoing health issues. Chest radiographs reveal abnormalities in a considerable portion of patients, with a small percentage showing deterioration.

THORAX (2021)

Article Public, Environmental & Occupational Health

Long-term survival benefit of male and multimorbid COVID-19 patients with 5-day remdesivir treatment

Lorinc Polivka et al.

JOURNAL OF GLOBAL HEALTH (2020)

Article Critical Care Medicine

Standardization of Spirometry 2019 Update An Official American Thoracic Society and European Respiratory Society Technical Statement

Brian L. Graham et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Respiratory System

2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung

Brian L. Graham et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

Article Respiratory System

Viral infection and aging as cofactors for the development of pulmonary fibrosis

Payal K Naik et al.

Expert Review of Respiratory Medicine (2010)