4.6 Review

The effect of Nigella sativa (black seed) on biomarkers of inflammation and oxidative stress: an updated systematic review and meta-analysis of randomized controlled trials

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

The effect of Nigella sativa on TAC and MDA in obese and overweight women: secondary analysis of a crossover, double blind, randomized clinical trial

Nooshin Abdollahi et al.

Summary: This study investigated the effect of N.S oil supplementation on total antioxidant capacity and oxidative stress in obese/overweight women. The results showed that supplementation with 2000 mg/d of N.S oil significantly increased serum total antioxidant capacity and reduced malondialdehyde levels. These findings suggest that taking N.S oil for 8 weeks can improve antioxidant conditions in obese and overweight adults.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2022)

Article Integrative & Complementary Medicine

Effect of Nigella Sativa Oil on Oxidative Stress, Inflammatory, and Glycemic Control Indices in Diabetic Hemodialysis Patients: A Randomized Double-Blind, Controlled Trial

Alireza Rahmani et al.

Summary: This study found that Nigella sativa supplementation significantly enhanced the levels of SOD, MDA, TAC, hs-CRP, HbA1c, and FBS in diabetic hemodialysis patients.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

Article Chemistry, Medicinal

Efficacy of nigella sativa oil on endothelial function and atherogenic indices in patients with coronary artery diseases: A randomized, double-blind, placebo-control clinical trial

Omid Mohammad Tavakoli-Rouzbehani et al.

Summary: A study found that supplementation with Nigella sativa (NS) oil has positive effects on endothelial function and atherogenic indices in patients with coronary artery disease (CAD), reducing levels of adhesion molecules and oxidative markers. However, further research is needed to confirm its efficacy as a therapeutic agent and complementary therapy.

PHYTOTHERAPY RESEARCH (2022)

Review Integrative & Complementary Medicine

An updated knowledge of Black seed (Nigella sativa Linn.): Review of phytochemical constituents and pharmacological properties

Md Faruque Ahmad et al.

Summary: N. sativa has been used since ancient times, with a strong historical, religious, and medicinal significance. Extensive research has confirmed its various pharmacological activities.

JOURNAL OF HERBAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

The effect of nigella sativa on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials

Rahele Sadat Montazeri et al.

Summary: The study suggests that consumption of Nigella Sativa (NS) can significantly reduce inflammatory response and oxidative stress markers, including lowering levels of hs-CRP, TNF-alpha, and MDA, while increasing levels of TAC and SOD. Further prospective studies with larger sample sizes and longer follow-up periods are needed to confirm these anti-inflammatory and antioxidant effects.

JOURNAL OF FOOD BIOCHEMISTRY (2021)

Article Chemistry, Medicinal

A randomized, double-blind, placebo-controlled, clinical trial to evaluate the benefits of Nigella sativa seeds oil in reducing cardiovascular risks in hypertensive patients

Parisa Shoaei-Hagh et al.

Summary: The study evaluated the efficacy, safety, and utility of Nigella sativa seeds oil as a complementary treatment for hypertension, glucose control, and lipid metabolism. Results showed that the use of N. sativa seeds oil as an adjunct to common medications exhibited significant antihypertensive effects and beneficial effects on glucose control and lipid metabolism in hypertensive patients.

PHYTOTHERAPY RESEARCH (2021)

Review Nutrition & Dietetics

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

Md. Abdul Hannan et al.

Summary: Black cumin is considered a functional food with a wide array of health benefits, including antioxidant, anti-inflammatory, immunomodulatory, and cell survival-promoting effects. Its active component TQ has demonstrated potential roles in various diseases and anti-cancer properties. Despite significant advances, black cumin and TQ are still far from clinical application.

NUTRIENTS (2021)

Review Cell Biology

Evolution of the Knowledge of Free Radicals and Other Oxidants

Sergio Di Meo et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Review Integrative & Complementary Medicine

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Ebrahim M. Yimer et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

Review Integrative & Complementary Medicine

The effect of Nigella sativa L. supplementation on serum C-reactive protein: A systematic review and meta-analysis of randomized controlled trials

Rahele Tavakoly et al.

COMPLEMENTARY THERAPIES IN MEDICINE (2019)

Review Toxicology

Oxidative damage and antioxidative system in algae

Maryam Rezayian et al.

TOXICOLOGY REPORTS (2019)

Article Medicine, Research & Experimental

Thymoquinone reduces mortality and suppresses early acute inflammatory markers of sepsis in a mouse model

Khalid M. Alkharfy et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Review Integrative & Complementary Medicine

Review on Clinical Trials of Black Seed (Nigella sativa) and Its Active Constituent, Thymoquinone

Alireza Tavakkoli et al.

JOURNAL OF PHARMACOPUNCTURE (2017)

Article Immunology

Immunomodulatory Effect of Nigella sativa Oil on T Lymphocytes in Patients with Rheumatoid Arthritis

Sorayya Kheirouri et al.

IMMUNOLOGICAL INVESTIGATIONS (2016)

Article Dentistry, Oral Surgery & Medicine

Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study

Pratik R. Pipalia et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY (2016)

Article Medicine, General & Internal

Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

David Moher et al.

SYSTEMATIC REVIEWS (2015)

Article Integrative & Complementary Medicine

Nigella sativa Fixed and Essential Oil Supplementation Modulates Hyperglycemia and Allied Complications in Streptozotocin-Induced Diabetes Mellitus

Muhammad Tauseef Sultan et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014)

Review Integrative & Complementary Medicine

Nigella sativa and Its Protective Role in Oxidative Stress and Hypertension

Xin-Fang Leong et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Article Pharmacology & Pharmacy

Thymoquinone: Potential cure for inflammatory disorders and cancer

Chern Chiuh Woo et al.

BIOCHEMICAL PHARMACOLOGY (2012)

Article Pharmacology & Pharmacy

Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats

Mohamed M. Sayed-Ahmed et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2007)

Article Immunology

Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages

A El-Mahmoudy et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2002)