Journal
FRONTIERS IN NEUROLOGY
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fneur.2023.1183306
Keywords
hyperhomocysteinemia; 5; 10-methylenetetrahydrofolate reductase; cerebral infarction; folic acid; vitamin B12; antiepileptic drug; epilepsy
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This case report describes a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. MRI showed a fronto-temporal ischemic lesion due to occlusion of the left middle cerebral artery. Clinical testing and imaging revealed hyperhomocysteinemia induced by the C677T polymorphism on MTHFR and multiple vitamin deficiencies. The C677T polymorphism on MTHFR is closely associated with hyperhomocysteinemia and folate deficiency in epileptic patients on multiple anti-convulsant drugs. Regular monitoring of plasma homocysteine and serum folic acid levels is recommended for epileptic patients on long-term regimens of multiple anti-epileptic drugs due to the independent risk of hyperhomocysteinemia causing stroke at a young age.
Hyperhomocysteinemia is an important risk factor for cerebral infarction. Herein, we report on a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. Magnetic resonance imaging showed a fronto-temporal ischemic lesion due to occlusion of the left middle cerebral artery. Clinical testing and imaging demonstrated that he had hyperhomocysteinemia induced by multiple factors including the C677T polymorphism on 5.10-methylenetetrahydrofolate reductase (MTHFR), and multiple vitamin deficiencies. The C677T polymorphism on MTHFR is closely related to hyperhomocysteinemia and folate deficiency in epileptic patients who are taking multiple anti-convulsants. Given hyperhomocysteinemia can independently cause stroke at a young age, physicians should periodically examine plasma homocysteine and serum folic acid levels in epileptic patients who are on long-term regimens of multiple anti-epileptic drugs.
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