Lipid metabolism and rheumatoid arthritis

As a chronic progressive autoimmune disease, rheumatoid arthritis (RA) is characterized by mainly damaging the synovium of peripheral joints and causing joint destruction and early disability. RA is also associated with a high incidence rate and mortality of cardiovascular disease. Recently, the relationship between lipid metabolism and RA has gradually attracted attention. Plasma lipid changes in RA patients are often detected in clinical tests, the systemic inflammatory status and drug treatment of RA patients can interact with the metabolic level of the body. With the development of lipid metabolomics, the changes of lipid small molecules and potential metabolic pathways have been gradually discovered, which makes the lipid metabolism of RA patients or the systemic changes of lipid metabolism after treatment more and more comprehensive. This article reviews the lipid level of RA patients, as well as the relationship between inflammation, joint destruction, cardiovascular disease, and lipid level. In addition, this review describes the effect of anti-rheumatic drugs or dietary intervention on the lipid profile of RA patients to better understand RA.

Automated summary

Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease that mainly affects the synovial membrane of peripheral joints, leading to joint destruction and disability. It is also associated with high incidence and mortality of cardiovascular disease. Recent studies have focused on the relationship between lipid metabolism and RA. Changes in plasma lipids in RA patients are often observed in clinical tests, and the systemic inflammation and medication for RA can affect the metabolic level of the body. Advances in lipid metabolomics have revealed lipid small molecule changes and potential metabolic pathways, providing a comprehensive understanding of lipid metabolism in RA patients. This article reviews the lipid profile of RA patients and the relationship between inflammation, joint destruction, cardiovascular disease, and lipid levels. It also discusses the impact of anti-rheumatic drugs or dietary interventions on the lipid profile of RA patients.