Related references
Note: Only part of the references are listed.Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack
Yuan Fang et al.
HEPATOLOGY (2023)
Manipulation of metabolic pathways to promote stem-like and memory T cell phenotypes for immunotherapy
Michael D. D. Claiborne
FRONTIERS IN IMMUNOLOGY (2023)
Tumour microenvironment as a predictive factor for immunotherapy in non-muscle-invasive bladder cancer
Aleksandra Semeniuk-Wojtas et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2023)
CD8+and FoxP3+T-Cell Cellular Density and Spatial Distribution After Programmed Death-Ligand 1 Check Point Inhibition
Joseph Curry et al.
LARYNGOSCOPE (2023)
Metabolism and epigenetics at the heart of T cell function
Leticia Soriano-Baguet et al.
TRENDS IN IMMUNOLOGY (2023)
T-cell exhaustion signatures characterize the immune landscape and predict HCC prognosis via integrating single-cell RNA-seq and bulk RNA-sequencing
Hao Chi et al.
FRONTIERS IN IMMUNOLOGY (2023)
Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer
Hannah N. Bell et al.
CELL METABOLISM (2023)
The hallmarks of cancer metabolism: Still emerging
Natalya N. Pavlova et al.
CELL METABOLISM (2022)
BCAT1: A risk factor in multiple cancers based on a pan-cancer analysis
Guo-Sheng Li et al.
CANCER MEDICINE (2022)
Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer
Sarah A. Best et al.
CELL METABOLISM (2022)
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
Mathias Wenes et al.
CELL METABOLISM (2022)
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
Lupeng Ye et al.
CELL METABOLISM (2022)
Lipid metabolism in T cell signaling and function
Seon Ah Lim et al.
NATURE CHEMICAL BIOLOGY (2022)
Epigenetic regulation of T cell exhaustion
Julia A. Belk et al.
NATURE IMMUNOLOGY (2022)
Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapy
Flor Navarro et al.
ONCOIMMUNOLOGY (2022)
Hypoxia, a key factor in the immune microenvironment
Jingyao Hu et al.
BIOMEDICINE & PHARMACOTHERAPY (2022)
Manipulating T-cell metabolism to enhance immunotherapy in solid tumor
Chen Chen et al.
FRONTIERS IN IMMUNOLOGY (2022)
Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation
Nancy Gudgeon et al.
CELL REPORTS (2022)
Carbon source availability drives nutrient utilization in CD8+ T cells
Irem Kaymak et al.
CELL METABOLISM (2022)
Phase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors
Emerson A. Lim et al.
CLINICAL CANCER RESEARCH (2022)
Oncometabolite D-2HG alters T cell metabolism to impair CD8(+) T cell function
Giulia Notarangelo et al.
SCIENCE (2022)
Lactate increases stemness of CD8+T cells to augment anti-tumor immunity
Qiang Feng et al.
NATURE COMMUNICATIONS (2022)
Lipids for CD8+ TILs: Beneficial or harmful?
Duojiao Wu et al.
FRONTIERS IN IMMUNOLOGY (2022)
Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity
Nina Dumauthioz et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2021)
Frontline Science: AMPK regulates metabolic reprogramming necessary for interferon production in human plasmacytoid dendritic cells
Harry J. Hurley et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2021)
Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas
Li Yi et al.
Aging-US (2021)
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
Arafath K. Najumudeen et al.
NATURE GENETICS (2021)
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
Nicole E. Scharping et al.
NATURE IMMUNOLOGY (2021)
MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects
Vivek Verma et al.
NATURE IMMUNOLOGY (2021)
Counteracting CAR T cell dysfunction
Mansour Poorebrahim et al.
ONCOGENE (2021)
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives
Xiaoqi Mao et al.
MOLECULAR CANCER (2021)
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
McLane J. Watson et al.
NATURE (2021)
Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy
Robert D. Leone et al.
CANCER IMMUNOLOGY RESEARCH (2021)
Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis
Maria Matias et al.
CELL REPORTS (2021)
Kdm6b Regulates the Generation of Effector CD8+ T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes
Tianhao Xu et al.
JOURNAL OF IMMUNOLOGY (2021)
Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer
Jones Gyamfi et al.
NPJ BREAST CANCER (2021)
Metabolic plasticity allows cancer cells to thrive under nutrient starvation
Wilhelm Palm
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
CAR-T cell therapy: current limitations and potential strategies
Robert C. Sterner et al.
BLOOD CANCER JOURNAL (2021)
The complex Integration of T-cell Metabolism and Immunotherapy
Matthew Z. Madden et al.
CANCER DISCOVERY (2021)
IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation
Adaobi Amobi-McCloud et al.
FRONTIERS IN IMMUNOLOGY (2021)
Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy
Guillermo O. Rangel Rivera et al.
FRONTIERS IN IMMUNOLOGY (2021)
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
Shihao Xu et al.
IMMUNITY (2021)
Polyamines instruct T-cell differentiation
Jie Wang
NATURE CELL BIOLOGY (2021)
Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer
Violet Y. Tu et al.
ANTIBODIES (2021)
Cancer metabolism: looking forward
Inmaculada Martinez-Reyes et al.
NATURE REVIEWS CANCER (2021)
Amino acids in cancer
Elizabeth L. Lieu et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2020)
Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan
Helen Kaiser et al.
EXPERIMENTAL GERONTOLOGY (2020)
Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development
Huafeng Zhang et al.
NATURE CELL BIOLOGY (2020)
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors
Haiping Wang et al.
NATURE IMMUNOLOGY (2020)
Competitive glucose metabolism as a target to boost bladder cancer immunotherapy
Julieta Afonso et al.
NATURE REVIEWS UROLOGY (2020)
Fatty Acid Oxidation Controls CD8+ Tissue-Resident Memory T-cell Survival in Gastric Adenocarcinoma
Run Lin et al.
CANCER IMMUNOLOGY RESEARCH (2020)
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Jean-Christophe Beltra et al.
IMMUNITY (2020)
Plasmacytoid Dendritic Cell Impairment in Metastatic Melanoma by Lactic Acidosis
Matilde Monti et al.
CANCERS (2020)
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
Min-Hee Oh et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells
Teresa Manzo et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2020)
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation
Yingjie Bian et al.
NATURE (2020)
Disturbed mitochondrial dynamics in CD8+TILs reinforce T cell exhaustion
Yi-Ru Yu et al.
NATURE IMMUNOLOGY (2020)
Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer
Xuguang Yang et al.
CANCER IMMUNOLOGY RESEARCH (2020)
Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design
Saba Ghassemi et al.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)
The Lipid Metabolic Landscape of Cancers and New Therapeutic Perspectives
Wenjun Wang et al.
FRONTIERS IN ONCOLOGY (2020)
A review of cancer immunotherapy: from the past, to the present, to the future
K. Esfahani et al.
CURRENT ONCOLOGY (2020)
Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity
Joy X. Wang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy
Ramon I. Klein Geltink et al.
NATURE METABOLISM (2020)
Metabolism of immune cells in cancer
Robert D. Leone et al.
NATURE REVIEWS CANCER (2020)
Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma
Saeed Daneshmandi et al.
CANCERS (2019)
Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?
Yoshihiro Ohue et al.
CANCER SCIENCE (2019)
Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
Xingzhe Ma et al.
CELL METABOLISM (2019)
Reactive oxygen species: a volatile driver of field cancerization and metastasis
Zehuan Liao et al.
MOLECULAR CANCER (2019)
Acetate Promotes T Cell Effector Function during Glucose Restriction
Jing Qiu et al.
CELL REPORTS (2019)
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
Selena Vigano et al.
FRONTIERS IN IMMUNOLOGY (2019)
Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer
Asmaa El-Kenawi et al.
BRITISH JOURNAL OF CANCER (2019)
Mechanisms and Implications of Metabolic Heterogeneity in Cancer
Jiyeon Kim et al.
CELL METABOLISM (2019)
A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors
Andrea Aloia et al.
CLINICAL CANCER RESEARCH (2019)
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
Robert D. Leone et al.
SCIENCE (2019)
Lactate modulates CD4+ T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis
G. Comito et al.
ONCOGENE (2019)
Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs
Alyson Haslam et al.
JAMA NETWORK OPEN (2019)
Clinical outcomes in non-small-cell lung cancer patients receiving concurrent metformin and immune checkpoint inhibitors
Muhammad Z. Afzal et al.
LUNG CANCER MANAGEMENT (2019)
Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer
Xianmin Mu et al.
CELL CYCLE (2018)
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Tina Cascone et al.
CELL METABOLISM (2018)
Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts
Brenda Raud et al.
IMMUNOLOGICAL REVIEWS (2018)
Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma
Yucheng Fu et al.
MEDICINE (2018)
Targeting Tumor Metabolism: A New Challenge to improve immunotherapy
Soumaya Kouidhi et al.
FRONTIERS IN IMMUNOLOGY (2018)
Targeting adenosine for cancer immunotherapy
Robert D. Leone et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)
PPAR-Induced Fatty Acid Oxidation in T Cells Increases the Number of Tumor-Reactive CD8+ T Cells and Facilitates Anti-PD-1 Therapy
Partha S. Chowdhury et al.
CANCER IMMUNOLOGY RESEARCH (2018)
Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy
Thibault Le Bourgeois et al.
FRONTIERS IN ONCOLOGY (2018)
Reinforce the antitumor activity of CD8+ T cells via glutamine restriction
Shogo Nabe et al.
CANCER SCIENCE (2018)
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
Marc O. Johnson et al.
CELL (2018)
Prognostic value of pretreatment serum lactate dehydrogenase level in pancreatic cancer patients A meta-analysis of 18 observational studies
Jianxin Gan et al.
MEDICINE (2018)
CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy
Monika C. Brunner-Weinzierl et al.
FRONTIERS IN IMMUNOLOGY (2018)
Unraveling the Complex Interplay Between T Cell Metabolism and Function
Ramon I. Klein Geltink et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 36 (2018)
Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer
S. Chouaib et al.
ONCOGENE (2017)
Biochemical Underpinnings of Immune Cell Metabolic Phenotypes
Benjamin A. Olenchock et al.
IMMUNITY (2017)
The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets
Bertrand Allard et al.
IMMUNOLOGICAL REVIEWS (2017)
Targeting A2 adenosine receptors in cancer
David Allard et al.
IMMUNOLOGY AND CELL BIOLOGY (2017)
ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway
Yang Zhao et al.
MOLECULAR CANCER (2017)
Blockade of adenosine A2A receptor enhances CD8+ T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma
Si-Rui Ma et al.
MOLECULAR CANCER (2017)
Glucose transporter GLUT1 expression and clinical outcome in solid tumors: a systematic review and meta-analysis
Ji Wang et al.
ONCOTARGET (2017)
Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment
Soumaya Kouidhi et al.
FRONTIERS IN IMMUNOLOGY (2017)
Mitochondrial OXPHOS Induced by RB1 Deficiency in Breast Cancer: Implications for Anabolic Metabolism, Stemness, and Metastasis
Eldad Zacksenhaus et al.
TRENDS IN CANCER (2017)
Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy
Ying Zhang et al.
CANCER CELL (2017)
The role of AMPK in T cell metabolism and function
Eric H. Ma et al.
CURRENT OPINION IN IMMUNOLOGY (2017)
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
Alessia Angelin et al.
CELL METABOLISM (2017)
Dysfunctional T cell metabolism in the tumor microenvironment
Kathryn E. Beckermann et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2017)
Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
Shari Pilon-Thomas et al.
CANCER RESEARCH (2016)
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction
Ende Zhao et al.
NATURE IMMUNOLOGY (2016)
Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer
Chunxia Li et al.
WORLD JOURNAL OF SURGICAL ONCOLOGY (2016)
Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses
Arabella Young et al.
CANCER CELL (2016)
Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α
Sangbin Lim et al.
CANCER RESEARCH (2016)
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche
David Clever et al.
CELL (2016)
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Roger Geiger et al.
CELL (2016)
Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells
Kristen E. N. Scott et al.
Cell Metabolism (2016)
The Emerging Hallmarks of Cancer Metabolism
Natalya N. Pavlova et al.
CELL METABOLISM (2016)
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
Almut Brand et al.
Cell Metabolism (2016)
Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
Omkar U. Kawalekar et al.
IMMUNITY (2016)
Memory CD8+ T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function
Maria L. Balmer et al.
IMMUNITY (2016)
Restricting Glutamine or Glutamine-Dependent Purine and Pyrimidine Syntheses Promotes Human T Cells with High FOXP3 Expression and Regulatory Properties
Barbara Metzler et al.
JOURNAL OF IMMUNOLOGY (2016)
Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
Wei Yang et al.
NATURE (2016)
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
Cristovao M. Sousa et al.
NATURE (2016)
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
Petros A. Tyrakis et al.
NATURE (2016)
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
Edouard Mullarky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Jared R. Mayers et al.
SCIENCE (2016)
The Warburg Effect: How Does it Benefit Cancer Cells?
Maria V. Liberti et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors
Ying Zhang et al.
ONCOTARGET (2016)
Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications
Suellen Ferro et al.
ONCOTARGET (2016)
T Cells and Cancer: How Metabolism Shapes Immunity
Barbara Molon et al.
FRONTIERS IN IMMUNOLOGY (2016)
Targeting CD73 in the tumor microenvironment with MEDI9447
Carl M. Hay et al.
ONCOIMMUNOLOGY (2016)
Fundamentals of cancer metabolism
Ralph J. DeBerardinis et al.
SCIENCE ADVANCES (2016)
Purinergic regulation of the immune system
Caglar Cekic et al.
NATURE REVIEWS IMMUNOLOGY (2016)
Novel drugs that target the metabolic reprogramming in renal cell cancer
Johannes C. van der Mijn et al.
CANCER & METABOLISM (2016)
Leucine Metabolism in T Cell Activation: mTOR Signaling and Beyond
Elitsa A. Ananieva et al.
ADVANCES IN NUTRITION (2016)
Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
Ping-Chih Ho et al.
CELL (2015)
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
Chih-Hao Chang et al.
CELL (2015)
Reactive oxygen species in the tumor niche triggers altered activation of macrophages and immunosuppression: Role of fluoxetine
Sayan Ghosh et al.
CELLULAR SIGNALLING (2015)
Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer
Mohamed Hassanein et al.
INTERNATIONAL JOURNAL OF CANCER (2015)
T cell metabolism drives immunity
Michael D. Buck et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
Michal Pawlak et al.
JOURNAL OF HEPATOLOGY (2015)
Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer
Li-Ying OuYang et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2015)
Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K
Rupert Courtnay et al.
MOLECULAR BIOLOGY REPORTS (2015)
Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth
Eduardo Balsa-Martinez et al.
MOLECULAR CELL (2015)
Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions
Shannan Cao et al.
PLOS ONE (2015)
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
Nikolaos Patsoukis et al.
NATURE COMMUNICATIONS (2015)
Lactate Regulates Metabolic and Proinflammatory Circuits in Control of T Cell Migration and Effector Functions
Robert Haas et al.
PLOS BIOLOGY (2015)
Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses
Paul A. Beavis et al.
CANCER IMMUNOLOGY RESEARCH (2015)
Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies
Fokhrul Hossain et al.
CANCER IMMUNOLOGY RESEARCH (2015)
Tryptophan-degrading enzymes in tumoral immune resistance
Nicolas van Baren et al.
FRONTIERS IN IMMUNOLOGY (2015)
Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells
Xiaojun Liu et al.
ONCOLOGY REPORTS (2015)
RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity
Brandon L. Probst et al.
PLOS ONE (2015)
Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance
Seon-Yeong Lee et al.
PLOS ONE (2015)
Molecular and cellular insights into T cell exhaustion
E. John Wherry et al.
NATURE REVIEWS IMMUNOLOGY (2015)
A Mechanism of Hypoxia-Mediated Escape from Adaptive Immunity in Cancer Cells
Ivraym B. Barsoum et al.
CANCER RESEARCH (2014)
Acetate Dependence of Tumors
Sarah A. Comerford et al.
CELL (2014)
Acetate Fuels the Cancer Engine
Costas A. Lyssiotis et al.
CELL (2014)
The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function
Andrew N. Macintyre et al.
CELL METABOLISM (2014)
Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer
Radoslaw Polanski et al.
CLINICAL CANCER RESEARCH (2014)
Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review)
David Hoskin et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2014)
Metabolic Reprogramming of Macrophages GLUCOSE TRANSPORTER 1 (GLUT1)-MEDIATED GLUCOSE METABOLISM DRIVES A PROINFLAMMATORY PHENOTYPE
Alex J. Freemerman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma
Hala Girgis et al.
MOLECULAR CANCER (2014)
Cancer Cells Differentially Activate and Thrive on De Novo Lipid Synthesis Pathways in a Low-Lipid Environment
Veerle W. Daniels et al.
PLOS ONE (2014)
Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR
Ulrike M. Litzenburger et al.
ONCOTARGET (2014)
Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment
Candace S. Hayes et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment
Mary B. Mockler et al.
FRONTIERS IN ONCOLOGY (2014)
How does the metabolism of tumour cells differ from that of normal cells
Nivea Dias Amoedo et al.
BIOSCIENCE REPORTS (2013)
Altered energy metabolism in cancer A unique opportunity for therapeutic intervention
Yi Zhang et al.
CANCER BIOLOGY & THERAPY (2013)
SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
Eric Letouze et al.
CANCER CELL (2013)
Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Veronica Estrella et al.
CANCER RESEARCH (2013)
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chih-Hao Chang et al.
CELL (2013)
Mitochondrial dysfunction in breast cancer cells prevents tumor growth Understanding chemoprevention with metformin
Rosa Sanchez-Alvarez et al.
CELL CYCLE (2013)
AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
Brandon Faubert et al.
CELL METABOLISM (2013)
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
Madhusudhanan Sukumar et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
LAT1 Is a Critical Transporter of Essential Amino Acids for Immune Reactions in Activated Human T Cells
Keitaro Hayashi et al.
JOURNAL OF IMMUNOLOGY (2013)
Tumor glycolysis as a target for cancer therapy: progress and prospects
Shanmugasundaram Ganapathy-Kanniappan et al.
MOLECULAR CANCER (2013)
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Jaekyoung Son et al.
NATURE (2013)
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
Linda V. Sinclair et al.
NATURE IMMUNOLOGY (2013)
BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
Martje Toenjes et al.
NATURE MEDICINE (2013)
Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
Arianna Calcinotto et al.
CANCER RESEARCH (2012)
Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth, Angiogenesis and Metastasis
Suveera Dhup et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
Gerritje J. W. van der Windt et al.
IMMUNITY (2012)
mTOR, metabolism, and the regulation of T-cell differentiation and function
Adam T. Waickman et al.
IMMUNOLOGICAL REVIEWS (2012)
Metabolic switching and fuel choice during T-cell differentiation and memory development
Gerritje J. W. van der Windt et al.
IMMUNOLOGICAL REVIEWS (2012)
Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation
Anna N. Mendler et al.
INTERNATIONAL JOURNAL OF CANCER (2012)
Signal Integration by Akt Regulates CD8 T Cell Effector and Memory Differentiation
Eui Ho Kim et al.
JOURNAL OF IMMUNOLOGY (2012)
Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma
Giovanni Forte et al.
JOURNAL OF IMMUNOLOGY (2012)
Metabolic pathways in T cell fate and function
Valerie A. Gerriets et al.
TRENDS IN IMMUNOLOGY (2012)
Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)
Jie Zheng
ONCOLOGY LETTERS (2012)
Cancer Cell Metabolism: One Hallmark, Many Faces
Jason R. Cantor et al.
CANCER DISCOVERY (2012)
Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines
Y. Wang et al.
BRITISH JOURNAL OF CANCER (2011)
Lactate: A Metabolic Key Player in Cancer
Franziska Hirschhaeuser et al.
CANCER RESEARCH (2011)
Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer
Tzu-Ting Huang et al.
CANCER SCIENCE (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Warburg phenotype in renal cell carcinoma: high expression of glucose-transporter 1 (GLUT-1) correlates with low CD8+ T-cell infiltration in the tumor
Katrin Singer et al.
INTERNATIONAL JOURNAL OF CANCER (2011)
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Ryan D. Michalek et al.
JOURNAL OF IMMUNOLOGY (2011)
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
Andrea Facciabene et al.
NATURE (2011)
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
Vinod P. Balachandran et al.
NATURE MEDICINE (2011)
Otto Warburg's contributions to current concepts of cancer metabolism
Willem H. Koppenol et al.
NATURE REVIEWS CANCER (2011)
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
Xiangdong Liu et al.
BLOOD (2010)
Reactive oxygen species in cancer
Geou-Yarh Liou et al.
FREE RADICAL RESEARCH (2010)
The metabolic life and times of a T-cell
Ryan D. Michalek et al.
IMMUNOLOGICAL REVIEWS (2010)
Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation
Erikka L. Carr et al.
JOURNAL OF IMMUNOLOGY (2010)
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
John Stagg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L. Pearce et al.
NATURE (2009)
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
Candace M. Cham et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2008)
Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B)
Yasuto Araki et al.
JOURNAL OF IMMUNOLOGY (2008)
Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways
Sarah R. Jacobs et al.
JOURNAL OF IMMUNOLOGY (2008)
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
Nancie J. MacIver et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2008)
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez et al.
NATURE REVIEWS CANCER (2007)
Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues
D. Lukashev et al.
CANCER AND METASTASIS REVIEWS (2007)
Inhibitory effect of tumor cell-derived lactic acid on human T cells
Karin Fischer et al.
BLOOD (2007)
L-arginine availability regulates T-lymphocyte cell-cycle progression
Paulo C. Rodriguez et al.
BLOOD (2007)
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
E Gottfried et al.
BLOOD (2006)
Fuel feeds function: Energy metabolism and the T-cell response
CJ Fox et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Regulation of immune responses by L- arginine metabolism
V Bronte et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans
N Gupta et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2005)
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
DH Munn et al.
IMMUNITY (2005)
Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers
V Bronte et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: A mechanism of tumor evasion
AH Zea et al.
CANCER RESEARCH (2005)
Glucose availability regulates IFN-γ production and p70S6 kinase activation in CD8+ effector T cells
CM Cham et al.
JOURNAL OF IMMUNOLOGY (2005)
Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination
C De Santo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
PC Rodriguez et al.
CANCER RESEARCH (2004)
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
C Uyttenhove et al.
NATURE MEDICINE (2003)
Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
E Oda et al.
SCIENCE (2000)
Share Paper
