☆ 4.8 Review

ADCC: An underappreciated correlate of cross-protection against influenza?

FRONTIERS IN IMMUNOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Multidisciplinary Sciences

Article Ad26.COV2.S priming provided a solid immunological base for mRNA-based COVID-19 booster vaccination

Daryl Geers et al.

Summary: The study investigated the immune response to homologous and heterologous booster vaccinations in individuals primed with Ad26.COV2.S. The findings showed that booster vaccinations increased functional antibodies targeting ancestral and emerging SARS-CoV-2 variants. Heterologous boosters induced higher levels of functional antibodies, while T-cell responses were similar for both types of boosters and maintained cross-reactivity towards variants. The study concluded that Ad26.COV2.S priming provided a strong immunological foundation for heterologous boosting to enhance immune responses against emerging variants.

ISCIENCE (2023)

Add to Collection

Editorial Material Microbiology

Antibodies face the challenge against human respiratory syncytial virus

Rory D. de Vries et al.

Summary: In the study published in the December 22 issue of Cell, Bartsch et al. conducted a functional profiling of the antibody response to respiratory syncytial virus in human adults who were vaccinated with an experimental adenovirus-based prefusion-stabilized HRSV-F vaccine and then intranasally challenged with HRSV. The authors identified various antibody effector functions as humoral correlates of protection.

CELL HOST & MICROBE (2023)

Add to Collection

Article Multidisciplinary Sciences

Ad26.COV2.S priming provided a solid immunological base for mRNA-based COVID-19 booster vaccination

Daryl Geers et al.

Summary: The study found that booster vaccinations after Ad26.COV2.S priming, especially heterologous boosters, could significantly increase functional antibodies targeting both ancestral and emerging variants of SARS-CoV-2. Meanwhile, T-cell responses remained similar and cross-reactive towards the variants regardless of homologous or heterologous booster vaccination. Additionally, minimal expansion of SARS-CoV-2-specific T-cell clones and no increase in the breadth of the T-cell repertoire were observed after booster vaccination. These findings suggest that Ad26.COV2.S priming provides a solid immunological foundation for heterologous boosting, enhancing humoral and cellular immune responses against emerging variants of concern.

ISCIENCE (2023)

Add to Collection

Article Microbiology

Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates

Tomer Zohar et al.

Summary: Through studying a nonhuman primate-challenge model, we found that immune protection against RSV infection is associated with antibody levels, neutralization, complement activity, and Fc-mediated effector mechanisms. These findings provide important insights for the development of future vaccines.

CELL HOST & MICROBE (2022)

Add to Collection

Article Multidisciplinary Sciences

Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination

Vijaykrishna Dhanasekaran et al.

Summary: Since the onset of the COVID-19 pandemic, public health measures and travel restrictions have heavily suppressed global influenza circulation. The genetic diversity of seasonal influenza viruses has significantly decreased, with the influenza B/Yamagata lineage not conclusively detected. Travel restrictions have confined the circulation of different influenza viruses to specific regions, leading to a continuous decline in global transmission of seasonal influenza, except in select hotspots that may seed future epidemics. Additionally, the selection of influenza vaccine strains and epidemic control face challenges due to waning population immunity and sporadic case detection.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Antibody effector functions are associated with protection from respiratory syncytial virus

Yannic C. Bartsch et al.

Summary: RSV infection is a major cause of severe respiratory tract infection and death in infants and the elderly. This study found that protection against RSV infection is linked to opsonophagocytic functions driven by IgA and differentially glycosylated RSV-specific IgG profiles, indicating the importance of functional humoral immune response in preventing RSV.

CELL (2022)

Add to Collection

Article Biochemistry & Molecular Biology

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

Raffael Nachbagauer et al.

Summary: New influenza virus vaccines based on chimeric hemagglutinin have been found to induce a broad, strong, durable and functional immune response targeting the conserved stalk of the hemagglutinin protein. This suggests that these chimeric hemagglutinins have the potential to be developed as universal vaccines that protect broadly against influenza viruses.

NATURE MEDICINE (2021)

Add to Collection

Article Microbiology

COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions

Opeyemi S. Adeniji et al.

Summary: The study suggests that qualitative differences in SARS-CoV-2-specific antibody-mediated innate immune functions may contribute to COVID-19 severity, with higher ADCD associated with higher inflammation and higher ADCP associated with lower inflammation. Understanding these qualitative features of antibodies could be crucial for developing effective and safe COVID-19 therapeutics and vaccines.

MBIO (2021)

Add to Collection

Review Medicine, Research & Experimental

Is a Universal Influenza Virus Vaccine Possible?

Raffael Nachbagauer et al.

ANNUAL REVIEW OF MEDICINE, VOL 71, 2020 (2020)

Add to Collection

Article Immunology

Activity of human serum antibodies in an influenza virus hemagglutinin stalk-based ADCC reporter assay correlates with activity in a CD107a degranulation assay

Veronika Chromikova et al.

VACCINE (2020)

Add to Collection

Article Virology

Analysis of the vaccine-induced influenza B virus hemagglutinin-specific antibody dependent cellular cytotoxicity response

Rory D. de Vries et al.

VIRUS RESEARCH (2020)

Add to Collection

Article Immunology

Primary Human Influenza B Virus Infection Induces Cross-Lineage Hemagglutinin Stalk-Specific Antibodies Mediating Antibody-Dependent Cellular Cytoxicity

Rory D. de Vries et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

Add to Collection

Article Immunology

Induction of Cross-Clade Antibody and T-Cell Responses by a Modified Vaccinia Virus Ankara-Based Influenza A(H5N1) Vaccine in a Randomized Phase 1/2a Clinical Trial

Rory D. de Vries et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

Add to Collection

Article Immunology

Influenza virus-specific antibody dependent cellular cytoxicity induced by vaccination or natural infection

Rory D. de Vries et al.

VACCINE (2017)

Add to Collection

Article Medicine, Research & Experimental

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

David J. DiLillo et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Add to Collection

Article Biotechnology & Applied Microbiology

Influenza virus A(H1N1) 2009 antibody-dependent cellular cytotoxicity in young children prior to the H1N1 pandemic

Annelies W. Mesman et al.

JOURNAL OF GENERAL VIROLOGY (2016)

Add to Collection

Article Multidisciplinary Sciences

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

Wenqian He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Add to Collection

Article Infectious Diseases

Safety and immunogenicity of a modified-vaccinia-virus-Ankara-based influenza A H5N1 vaccine: a randomised, double-blind phase 1/2a clinical trial

Joost H. C. M. Kreijtz et al.

LANCET INFECTIOUS DISEASES (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo

David J. DiLillo et al.

NATURE MEDICINE (2014)

Add to Collection

Article Virology

Detection of influenza A virus homo- and heterosubtype-specific memory B-cells using a novel protein microarray-based analysis tool

Dominique C. Baas et al.

JOURNAL OF MEDICAL VIROLOGY (2013)

Add to Collection

Article Multidisciplinary Sciences

Profiling of Humoral Response to Influenza A(H1N1)pdm09 Infection and Vaccination Measured by a Protein Microarray in Persons with and without History of Seasonal Vaccination

Elisabeth G. W. Huijskens et al.

PLOS ONE (2013)

Add to Collection

Article Multidisciplinary Sciences

Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

Bjorn F. Koel et al.

SCIENCE (2013)

Add to Collection

Article Infectious Diseases

Profiling of humoral immune responses to influenza viruses by using protein microarray

M. Koopmans et al.

CLINICAL MICROBIOLOGY AND INFECTION (2012)

Add to Collection

Article Infectious Diseases

Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients

Ingrid H. M. Friesema et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2012)

Add to Collection

Article Immunology

Prevalence of Antibodies against Seasonal Influenza A and B Viruses in Children in Netherlands

R. Bodewes et al.

CLINICAL AND VACCINE IMMUNOLOGY (2011)

Add to Collection

Article Immunology

Identifying long-term memory B-cells in vaccinated children despite waning antibody levels specific for Bordetella pertussis proteins

Lotte H. Hendrikx et al.

VACCINE (2011)

Add to Collection

Article Biochemistry & Molecular Biology

The evolutionary dynamics of human influenza B virus

Rubing Chen et al.

JOURNAL OF MOLECULAR EVOLUTION (2008)

Add to Collection

Article Multidisciplinary Sciences

Mapping the antigenic and genetic evolution of influenza virus

DJ Smith et al.

SCIENCE (2004)

Add to Collection

Article Immunology

Sex-associated differences in the antibody-dependent cellular cytotoxicity antibody response to measles vaccines

S Atabani et al.

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.