☆ 4.8 Review

Function and regulation of cGAS-STING signaling in infectious diseases

FRONTIERS IN IMMUNOLOGY (2023)

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Conggang Zhang et al.

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Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP

Guijun Shang et al.

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cGAS in action: Expanding roles in immunity and inflammation

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Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection

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Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling

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A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

Baoyu Zhao et al.

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Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

Carina C. de Oliveira Mann et al.

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cGAS-STING responses are dampened in high-risk HPV type 16 positive head and neck squamous cell carcinoma cells

Mushfiq H. Shaikh et al.

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Sebastian Lourido

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The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING

Peiyan Wang et al.

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Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses

Miyu Moriyama et al.

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Monocyte-derived dendritic cells in malaria

Isabella C. Hirako et al.

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The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

Sonal Srikanth et al.

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HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

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Tight nuclear tethering of cGAS is essential for preventing autoreactivity

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Streptococcus pneumoniae: Invasion and Inflammation

Allister J. Loughran et al.

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High-level expression of STING restricts susceptibility to HBV by mediating type III IFN induction

Hiromichi Dansako et al.

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Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria

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SnapShot: cGAS-STING Signaling

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Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling

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Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

Shouya Feng et al.

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Herpes Simplex Virus 1 Tegument Protein VP22 Abrogates cGAS/STING-Mediated Antiviral Innate Immunity

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Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1

Chunfu Zheng

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Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis

Sabine Ehrt et al.

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DNA-induced liquid phase condensation of cGAS activates innate immune signaling

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STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection

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Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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Targeting STING with covalent small-molecule inhibitors

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SAMHD1 acts at stalled replication forks to prevent interferon induction

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The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans

Juan Sebastian Ruiz-Moreno et al.

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cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses

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Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase

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Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

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The Complement Anaphylatoxins C5a and C3a Suppress IFN-β Production in Response to Listeria monocytogenes by Inhibition of the Cyclic Dinucleotide-Activated Cytosolic Surveillance Pathway

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Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41

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Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-κB Activation

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FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions

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Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

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Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi

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Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection

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Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense

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Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

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Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection

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Dengue virus activates cGAS through the release of mitochondrial DNA

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STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum

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Ubiquitination of STING at lysine 224 controls IRF3 activation

Guoxin Ni et al.

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STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection

Xin Wang et al.

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HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

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Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality

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Cyclic di-AMP Released from Staphylococcus aureus Biofilm Induces a Macrophage Type I Interferon Response

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RNase H2 catalytic core Aicardi-Goutieres syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice

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Inhibition of hepatitis B virus replication by activation of the cGAS-STING pathway

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Herpes Simplex Virus 1 Serine Protease VP24 Blocks the DNA-Sensing Signal Pathway by Abrogating Activation of Interferon Regulatory Factor 3

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Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

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Activation of STING requires palmitoylation at the Golgi

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Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS

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HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells

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Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model

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STING-Licensed Macrophages Prime Type I IFN Production by Plasmacytoid Dendritic Cells in the Bone Marrow during Severe Plasmodium yoelii Malaria

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STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

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The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

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Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

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Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

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Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management

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Type I interferonopathies: Mendelian type I interferon up-regulation

Yanick J. Crow

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cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection

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Mitochondrial DNA stress primes the antiviral innate immune response

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Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

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DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

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Human papillomaviruses: shared and distinct pathways for pathogenesis

Denise A. Galloway et al.

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Induction of Interferon-Stimulated Genes by IRF3 Promotes Replication of Toxoplasma gondii

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Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway

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The DNA Sensor, Cyclic GMP-AMP Synthase, Is Essential for Induction of IFN-β during Chlamydia trachomatis Infection

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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

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Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality

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DNA Degradation and Its Defects

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Correction: Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

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Toll-like receptor signaling pathways

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The mycobiota: interactions between commensal fungi and the host immune system

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Cyclic [G(2′,5′) pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

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Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice

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Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

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The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

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Toll-Like Receptor 7 Mediates Early Innate Immune Responses to Malaria

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Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence

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STING/MPYS Mediates Host Defense against Listeria monocytogenes Infection by Regulating Ly6Chi Monocyte Migration

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HIV-1 evades innate immune recognition through specific cofactor recruitment

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cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

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Structural mechanism of cytosolic DNA sensing by cGAS

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Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

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Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

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Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

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Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

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Monocytes and macrophages in malaria: protection or pathology?

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STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

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Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

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The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

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Activation and regulation of the inflammasomes

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Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

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Reduced interferon (IFN)-α conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality

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Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

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American Trypanosomiasis (Chagas Disease)

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INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2012)

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Inflammasome-Dependent IFN-γ Drives Pathogenesis in Streptococcus pneumoniae Meningitis

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Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING

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Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

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The structural basis for the sensing and binding of cyclic di-GMP by STING

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Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

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STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

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The Biology and Life-Cycle of Human Papillomaviruses

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Type I Interferons Promote Fatal Immunopathology by Regulating Inflammatory Monocytes and Neutrophils during Candida Infections

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Immunomodulatory functions of type I interferons

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Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

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The N-Ethyl-N-Nitrosourea-Induced Goldenticket Mouse Mutant Reveals an Essential Function of Sting in the In Vivo Interferon Response to Listeria monocytogenes and Cyclic Dinucleotides

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Staphylococcus aureus Biofilms Prevent Macrophage Phagocytosis and Attenuate Inflammation In Vivo

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Pattern Recognition Receptors and Inflammation

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Protein-DNA Complex Is the Exclusive Malaria Parasite Component That Activates Dendritic Cells and Triggers Innate Immune Responses

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The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

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Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human

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Synthetic Plasmodium-Like Hemozoin Activates the Immune Response: A Morphology - Function Study

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Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Tatsuya Saitoh et al.

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HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

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The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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Synthetic GPI array to study antitoxic malaria response

Faustin Kamena et al.

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Review Parasitology

TLR-mediated cell signaling by malaria GPIs

D. Channe Gowda

TRENDS IN PARASITOLOGY (2007)

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Article Multidisciplinary Sciences

Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9

Peggy Parroche et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Immunology

Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells

Anne-Marit Sponaas et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

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Review Biochemistry & Molecular Biology

Pathogen recognition and innate immunity

S Akira et al.

CELL (2006)

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Article Biochemistry & Molecular Biology

Induction of proinflammatory responses in macrophages by the Glycosylphosphatidylinositols of Plasmodium falciparum -: Cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity

G Krishnegowda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Review Immunology

Immunology of hepatitis B virus and hepatitis C virus infection

B Rehermann et al.

NATURE REVIEWS IMMUNOLOGY (2005)

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Article Immunology

Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin

C Coban et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2005)

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Article Immunology

Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a toll-like receptor 9-dependent pathway

S Pichyangkul et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Critical Care Medicine

Plasma interferon-γ and interleukin-10 concentrations in systemic meningococcal disease compared with severe systemic Gram-positive septic shock

A Bjerre et al.

CRITICAL CARE MEDICINE (2004)

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Article Immunology

Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes

V Auerbuch et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

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Article Immunology

Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to listeria infection

JA Carrero et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

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Article Immunology

Type I interferon production enhances susceptibility to Listeria monocytogenes infection

RM O'Connell et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

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Article Medicine, General & Internal

Epidemiologic classification of human papillomavirus types associated with cervical cancer

N Muñoz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

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Review Multidisciplinary Sciences

Genome sequence of the human malaria parasite Plasmodium falciparum

MJ Gardner et al.

NATURE (2002)

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Article Multidisciplinary Sciences

Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria

L Schofield et al.

NATURE (2002)

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Review Medicine, General & Internal

Herpes simplex virus infections

RJ Whitley et al.

LANCET (2001)

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Article Immunology

Low interleukin-12 activity in severe Plasmodium falciparum malaria

AJF Luty et al.

INFECTION AND IMMUNITY (2000)

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