4.8 Article

Cladribine treatment specifically affects peripheral blood memory B cell clones and clonal expansion in multiple sclerosis patients

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

Tobias Lanz et al.

Summary: Multiple sclerosis (MS) is an autoimmune disease where autoreactive lymphocytes attack the central nervous system. Epstein-Barr virus (EBV) infection has been linked to MS, with molecular mimicry between EBV nuclear antigen 1 (EBNA1) and central nervous system protein GlialCAM. EBNA1 immunization exacerbates disease in MS mouse models and anti-EBNA1 and anti-GlialCAM antibodies are prevalent in MS patients, providing a mechanistic link between MS and EBV and guiding the development of new MS therapies.

NATURE (2022)

Review Clinical Neurology

Evolution of Anti-B Cell Therapeutics in Autoimmune Neurological Diseases

Panos Stathopoulos et al.

Summary: B cells play an important role in the etiology of autoimmune neurological disorders, acting as antigen-presenting cells and regulating the immune response. Depletion of B cells has become a promising treatment strategy. This paper summarizes the basic aspects of B cell biology, discusses the roles of B cells in neurological autoimmunities, and highlights the efficacy and practical considerations of anti-B cell therapies in different neurological disorders.

NEUROTHERAPEUTICS (2022)

Article Clinical Neurology

Analysis of frequency and severity of relapses in multiple sclerosis patients treated with cladribine tablets or placebo: The CLARITY and CLARITY Extension studies

Nicola De Stefano et al.

Summary: The study demonstrates that oral treatment with cladribine tablets significantly reduces the relapse rate and severity in patients with multiple sclerosis, with sustained efficacy even without further treatment.

MULTIPLE SCLEROSIS JOURNAL (2022)

Article Clinical Neurology

Immunological consequences of cladribine treatment in multiple sclerosis: A real-world study

Leoni Rolfes et al.

Summary: Cladribine treatment led to selective alterations in immune cell populations, with the most marked reduction seen in B cells. Despite significant reduction in B cells, immunoglobulin levels remained unaffected. Herpes infections were more likely to occur during lymphopenia.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Article Clinical Neurology

Differential Effects of Fingolimod and Natalizumab on B Cell Repertoires in Multiple Sclerosis Patients

M. C. Kowarik et al.

Summary: Natalizumab and fingolimod have differential effects on B cell populations in multiple sclerosis, with fingolimod treatment contracting peripheral blood B cells while natalizumab treatment expands them. The clonal overlap between CSF and PB B cells is reduced with natalizumab but remains stable with fingolimod therapy. These findings suggest that the two therapies have distinct impacts on the exchange and clonal expansion of B cells in MS patients.

NEUROTHERAPEUTICS (2021)

Article Immunology

Humoral immune response in multiple sclerosis patients following PfizerBNT162b2 COVID19 vaccination: Up to 6 months cross-sectional study

Anat Achiron et al.

Summary: The study found that most multiple sclerosis (MS) patients who were either untreated or treated with certain drugs exhibited a protective immune response following PfizerBNT162b2 vaccination. In contrast, patients treated with other medications showed a weaker immune response.

JOURNAL OF NEUROIMMUNOLOGY (2021)

Article Cell Biology

Immunomodulatory Effects Associated with Cladribine Treatment

Nicolas Fissolo et al.

Summary: Cladribine exerts regulatory effects on the proliferation and apoptosis of lymphocyte subsets while its impact on immune cell activation is mediated through both DCK-dependent and independent pathways. It shows cytotoxicity on monocytes and dendritic cells, affecting the activation of monocytes but not the maturation of dendritic cells.

CELLS (2021)

Review Medicine, General & Internal

Next Generation Sequencing of Cerebrospinal Fluid B Cell Repertoires in Multiple Sclerosis and Other Neuro-Inflammatory Diseases-A Comprehensive Review

Christoph Ruschil et al.

Summary: The role of B cells in neuro-inflammatory diseases has been well established through NGS studies, revealing B cell trafficking patterns between CSF and peripheral blood. In conditions like multiple sclerosis, specific B cell maturation in CSF and exchange across the BBB are detectable, suggesting intense B cell exchange possibly contributing to autoimmune circuits.

DIAGNOSTICS (2021)

Review Clinical Neurology

B cells in multiple sclerosis - from targeted depletion to immune reconstitution therapies

Maria T. Cencioni et al.

Summary: This Review discusses the roles of B cells in multiple sclerosis, highlighting the involvement of B cells in disease pathogenesis and the potential mechanisms underlying the abnormalities in B cell function in MS.

NATURE REVIEWS NEUROLOGY (2021)

Letter Biotechnology & Applied Microbiology

The nf-core framework for community-curated bioinformatics pipelines

Philip A. Ewels et al.

NATURE BIOTECHNOLOGY (2020)

Article Multidisciplinary Sciences

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Susan A. Kennedy et al.

NATURE COMMUNICATIONS (2020)

Article Immunology

Specific Induction of Double Negative B Cells During Protective and Pathogenic Immune Responses

Christoph Ruschil et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Clinical Neurology

Effect of cladribine tablets on lymphocyte reduction and repopulation dynamics in patients with relapsing multiple sclerosis

Giancarlo Comi et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2019)

Article Multidisciplinary Sciences

Analysis of the B cell receptor repertoire in six immune-mediated diseases

R. J. M. Bashford-Rogers et al.

NATURE (2019)

Review Neurosciences

B cells in autoimmune and neurodegenerative central nervous system diseases

Joseph J. Sabatino et al.

NATURE REVIEWS NEUROSCIENCE (2019)

Article Clinical Neurology

Effects of cladribine tablets on lymphocyte subsets in patients with multiple sclerosis: an extended analysis of surface markers

Olaf Stuve et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2019)

Article Clinical Neurology

Cladribine treatment of multiple sclerosis is associated with depletion of memory B cells

Bryan Ceronie et al.

JOURNAL OF NEUROLOGY (2018)

Article Clinical Neurology

Cladribine tablets added to IFN-β in active relapsing MS The ONWARD study

Xavier Montalban et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2018)

Letter Biotechnology & Applied Microbiology

Nextflow enables reproducible computational workflows

Paolo Di Tommaso et al.

NATURE BIOTECHNOLOGY (2017)

Article Medicine, General & Internal

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

S. L. Hauser et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Clinical Neurology

CNS Aquaporin-4-specific B cells connect with multiple B-cell compartments in neuromyelitis optica spectrum disorder

Markus C. Kowarik et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2017)

Review Medicine, General & Internal

Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis

David Baker et al.

EBIOMEDICINE (2017)

Article Medicine, Research & Experimental

Clonal relationships of CSF B cells in treatment-naive multiple sclerosis patients

Erica L. Eggers et al.

JCI INSIGHT (2017)

Article Biochemical Research Methods

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

Stefka Tyanova et al.

NATURE PROTOCOLS (2016)

Article Clinical Neurology

Insufficient disease inhibition by intrathecal rituximab in progressive multiple sclerosis

Mika Komori et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2016)

Article Biochemical Research Methods

Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data

Namita T. Gupta et al.

BIOINFORMATICS (2015)

Article Biochemical Research Methods

pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires

Jason A. Vander Heiden et al.

BIOINFORMATICS (2014)

Article Cell Biology

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

Arumugam Palanichamy et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Cell Biology

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

Joel N. H. Stern et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Article Clinical Neurology

Impact of cladribine therapy on changes in circulating dendritic cell subsets, T cells and B cells in patients with multiple sclerosis

Krystyna Mitosek-Szewczyk et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2013)

Article Biochemistry & Molecular Biology

IgBLAST: an immunoglobulin variable domain sequence analysis tool

Jian Ye et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Multidisciplinary Sciences

Widespread RNA and DNA Sequence Differences in the Human Transcriptome

Mingyao Li et al.

SCIENCE (2011)

Article Medicine, General & Internal

A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis

Gavin Giovannoni et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)